**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 123-91-1 |1,4-Dioxane | >99 | 204-661-8 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XN F
Risk Phrases: 11 19 36/37 40 66
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. May form explosive peroxides. Irritating to eyes
and respiratory system. Limited evidence of a carcinogenic effect.
Repeated exposure may cause skin dryness or cracking.Hygroscopic
(absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
May cause skin irritation. May be absorbed through the skin in
harmful amounts. Prolonged and/or repeated contact may cause
irritation and/or dermatitis.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause central nervous system depression, characterized
by excitement, followed by headache, dizziness, drowsiness, and
nausea. Advanced stages may cause collapse, unconsciousness, coma
and possible death due to respiratory failure.
Inhalation:
Effects may be delayed. Inhalation of high concentrations may cause
central nervous system effects characterized by nausea, headache,
dizziness, unconsciousness and coma. Causes respiratory tract
irritation. Inhalation of vapor may cause severe respiratory tract
irritation. Olfactory fatigue may occur.
Chronic:
May cause liver and kidney damage. May cause cancer according to
animal studies.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
Possible aspiration hazard. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Flammable liquid and
vapor. May form explosive peroxides. May accumulate static
electrical charges, and may cause ignition of its own vapors.
Approach fire from upwind to avoid hazardous vapors and toxic
decomposition products. Vapors are heavier than air and may travel to
a source of ignition and flash back. Vapors can spread along the
ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or alcohol-resistant
foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Flush spill area with
water. Provide ventilation. A vapor suppressing foam may be used to
reduce vapors.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use spark-proof tools and explosion proof
equipment. Loosen closure cautiously before opening. Avoid contact
with eyes, skin, and clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Take
precautionary measures against static discharges. If peroxide
formation is suspected, do not open or move container. Do not
pressurize, cut, weld, braze, solder, drill, grind, or expose empty
containers to heat, sparks or open flames. Use only with adequate
ventilation. Avoid breathing vapor or mist.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Flammables-area. After opening, purge container with nitrogen before
reclosing. Periodically test for peroxide formation on long-term
storage. Addition of water or appropriate reducing materials will
lessen peroxide formation. Containers should be dated when opened and
tested periodically for the presence of peroxides. Should crystals
form in a peroxidizable liquid, peroxidation may have occurred and
the product should be considered extremely dangerous. In this
instance, the container should only be opened remotely by
professionals. All peroxidizable substances should be stored away
from heat and light and be protected from ignition sources.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
CAS# 123-91-1:
United Kingdom, WEL - TWA: 25 ppm TWA; 91 mg/m3 TWA
United Kingdom, WEL - STEL: 100 ppm STEL; 366 mg/m3 STEL
United States OSHA: 100 ppm TWA; 360 mg/m3 TWA
Belgium - TWA: 25 ppm VLE; 91 mg/m3 VLE
France - VME: 10 ppm VME; 35 mg/m3 VME
France - VLE: 40 ppm VLE; 140 mg/m3 VLE
Germany: 20 ppm TWA; 73 mg/m3 TWA
Germany: Skin absorber
Japan: 10 ppm OEL; 36 mg/m3 OEL
Malaysia: 20 ppm TWA; 72.1 mg/m3 TWA
Netherlands: 22 ppm STEL; 80 mg/m3 STEL
Netherlands: 11 ppm MAC; 40 mg/m3 MAC
Russia: 10 mg/m3 TWA
Spain: 20 ppm VLA-ED; 74 mg/m3 VLA-ED
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear nitrile-latex gloves, apron, and/or clothing.
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear, colorless
Odor: ethereal odor
pH: Not available.
Vapor Pressure: 29 mm Hg @ 20 deg C
Viscosity: 0.012cP @ 25 deg C
Boiling Point: 101 deg C
Freezing/Melting Point: 12 deg C
Autoignition Temperature: 180 deg C ( 356.00 deg F)
Flash Point: 12 deg C ( 53.60 deg F)
Explosion Limits, lower: 2.0%
Explosion Limits, upper: 22.0%
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.0300 g/cm3
Molecular Formula: C4H8O2
Molecular Weight: 88.11
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Prolonged exposure to air and sunlight may form unstable peroxides.
Tends to form explosive peroxides; especially when anhydrous. Under
normal storage conditions, peroxidizable compounds can form and
accumulate peroxides which may explode when subjected to heat or
shock. This material is most hazardous when peroxide levels are
concentrated by distillation or evaporation.
Conditions to Avoid:
Light, ignition sources, excess heat, electrical sparks.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Has not been reported
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 123-91-1: JG8225000
LD50/LC50:
CAS# 123-91-1: Draize test, rabbit, eye: 100 mg Severe; Draize test,
rabbit, eye: 100 mg/24H Moderate; Inhalation, mouse: LC50 = 37
gm/m3/2H; Inhalation, rat: LC50 = 46 gm/m3/2H; Oral, mouse: LD50 =
5300 mg/kg; Oral, rabbit: LD50 = 2 gm/kg; Oral, rat: LD50 = 4200
mg/kg; Skin, rabbit: LD50 = 7600 uL/kg.
Carcinogenicity:
1,4-Dioxane -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 1/1/88
NTP: Suspect carcinogen
IARC: Group 2B carcinogen
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Bluegill/Sunfish: LC50 = >10,000mg/L; 96 Hr.; Static
conditions, 23 degrees CWater flea Daphnia: EC50 =163 mg/L; 48 Hr.;
Static Condition, 20-21 degrees C
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: Dioxane
Hazard Class: 3
UN Number: 1165
Packing Group: II
IMO
Shipping Name: DIOXANE
Hazard Class: 3
UN Number: 1165
Packing Group: II
RID/ADR
Shipping Name: Dioxane
Hazard Class: 3
UN Number: 1165
Packing group:
USA RQ: CAS# 123-91-1: 100 lb final RQ; 45.4 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 36/37 Irritating to eyes and respiratory system.
R 40 Limited evidence of a carcinogenic effect.
R 66 Repeated exposure may cause skin dryness or
cracking.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 36/37 Wear suitable protective clothing and
gloves.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 123-91-1: 2
Canada
CAS# 123-91-1 is listed on Canada's DSL List.
CAS# 123-91-1 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 123-91-1 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 3/01/2001 Revision #2 Date: 7/23/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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