*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VT5710000
CHEMICAL NAME : Senecionan-11,16-dione, 12-hydroxy-
CAS REGISTRY NUMBER : 130-01-8
BEILSTEIN REFERENCE NO. : 0934445
LAST UPDATED : 199612
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C18-H25-N-O5
MOLECULAR WEIGHT : 335.44
WISWESSER LINE NOTATION : T55-12- 1A Q EN IOVY OVO BUTJ KU2 M NQ N
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Aureine
* 12-Hydroxysenecionan-11,16-dione
* Senecionin
* Senecionine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 15,19,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
12,299,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 41200 ug/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 87,382,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
28,2237,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 64 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 75,69,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 61 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - hepatitis (hepatocellular necrosis), diffuse
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued.
Volume(issue)/page/year: 5,53,1949
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 140 mg/kg
SEX/DURATION : female 4-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 77,461,1988
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 20 umol/L
REFERENCE :
ZEVBA5 Zeitschrift fuer Vererbungslehre. (Berlin, Fed. Rep. Ger.) V.89-98,
1958-66. For publisher information, see MGGEAE. Volume(issue)/page/year:
91,74,1960
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 700 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
45,3125,1985
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 90 mg/kg
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,42,1981
*** REVIEWS ***
TOXICOLOGY REVIEW
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 78,99,1972
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Senecio kunthianus Wall. ex DC., extractSUBSTANCE DEFINITION :Plant belonging to the family AsteraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 8022-56-8 |
Senecio linifolius Cl., extractSUBSTANCE DEFINITION :Plant belonging to the family AsteraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 8022-56-8 |
Sageratia hamosa Brongn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RhamnaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 8022-56-8 |
Senecio longilobusSUBSTANCE DEFINITION :Contains pyrrolizidine alkaloidsREFERENCE :CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & ChestnutSts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:28,2237,1968
| 8022-56-8 |
Senecionan-11,16-dione,20-chloro-15,20-dihydro-12,15-dihydroxy-,(15-alpha,20R)-
| 480-75-1 |
Senecionan-11,16-dione,20-chloro-15,20-dihydro-12,15-dihydroxy-,hydrochloride, (15-alpha,20R)-
| 7251-11-8 |
Senecionan-11,16-dione,3,8-didehydro-12,18-dihydroxy-
| 23092-97-9 |
Senecionan-11,16-dione,15,20-dihydro-13,19:15,20-diepoxy-12-hydroxy-,(13-alpha,15-alpha, 20S)-
| 81855-31-4 |
Senecionan-11,16-dione, 6,12-dihydroxy-, (6-beta)-
| 5096-49-1 |
Senecionan-11,16-dione, 12,18-dihydroxy-, (15E)-
| 15503-87-4 |
Senecionan-11,16-dione,15,20-epoxy-15,20-dihydro-12-hydroxy-, hydrochloride,(15-alpha,20S)-
| 15503-87-4 |
Senecionan-11,16-dione, 13,19-epoxy-12-hydroxy-,(13-alpha)-
| 95723-62-9 |
Senecionan-11,16-dione, 12-hydroxy-
| 130-01-8 |
Sageretia oppositifolia Brongn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family RhamnaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 130-01-8 |
Senecionan-11,16-dione, 12-hydroxy-, hydrochloride
| 130-01-8 |
Senecionan-11,16-dione, 12-hydroxy-, 4-oxide
| 13268-67-2 |
Senecionan-11,16-dione, 12-hydroxy-, andseneciphylline mixture (80:20)
| 13268-67-2 |
Senecionanium,12-(acetyloxy)-3,8-didehydro-4-methyl-11,16-dioxo-,(12-beta,15E)-, acetate
| 71673-83-1 |
Senecionanium,12-(acetyloxy)-14,15,20,21-tetradehydro-15,20-dihydro-8-hydroxy-4-methyl- 11,16-dioxo-,(8-xi,12-beta,14-Z)-
| 33979-15-6 |
Senecionanium, 8,12-dihydroxy-4-methyl-11,16-dioxo-
| 2318-18-5 |
Senecionanium,8,12,18-trihydroxy-4-methyl-11,16-dioxo-
| 26782-43-4 |
Senecio nemorensis fuchsii, alkaloidal extractSUBSTANCE DEFINITION :Alkaloidal extract contains the two pyrrolizidine alkaloidsfuchsisenecionine and senecionineREFERENCE :ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-Volume(issue)/page/year: 32,144,1982
| 26782-43-4 |
Senecionine, didehydro-
| 28379-63-7 |
Senecio pedunculatus Hk. f. & T., extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,228,1978
| 28379-63-7 |
Sagina japonica extractSUBSTANCE DEFINITION :Flavons, saponins, and volatile oils of S. japonica extractsREFERENCE :YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International BookTrading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. Forpublisher information, see ZYZAEU. Volume(issue)/page/year: 15,1,1980
| 28379-63-7 |
Senecio riddellii, crude alkaloid
| 28379-63-7 |
Senecio rufinervis DC, extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 28379-63-7 |
Senecio vulgaris, plantSUBSTANCE DEFINITION :Contains pyrrolizidine alkaloidsREFERENCE :TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AEAmsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 15,19,1983
| 28379-63-7 |
Seneciphylline
| 480-81-9 |
Seneciphylline, hydrochloride
| 1098-44-8 |
Senna
| 8013-11-4 |
Sennosides A + B 99%
| 8013-11-4 |
Sennosides A + B 20% calcium salt
| 8013-11-4 |
Sennosides 45% calcium salt
| 8013-11-4 |
Sennosides 5.5% calcium salt
| 8013-11-4 |
Sagittaria guayanensis H.B. & K., extractSUBSTANCE DEFINITION :Plant belonging to the family AlismaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 8013-11-4 |
Senomycin
| 102418-11-1 |
SensoSUBSTANCE DEFINITION :Dried preparation of the skin of the Chinese toadREFERENCE :JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-Volume(issue)/page/year: 8,347,1916
| 102418-11-1 |
Sepia esculenta Hoyle, crude extract
| 102418-11-1 |
Sepiolite
| 18307-23-8 |
Sepiolite (Mg2H2(SiO3)3.H2O)
| 15501-74-3 |
Sepiolite (Mg2H2(SiO3)3.xH2O)OTHER CAS REGISTRY NOS. : 12639-43-953664-61-261045-54-361180-58-364418-10-683271-15-2
| 15501-74-3 |
Septamycin
| 54927-63-8 |
Septamycin,5,15-didemethoxy-14-demethyl-5-hydroxy-27-methoxy-18,20-dimethyl-, monosodium salt,(2S,3R,4R,5R,6S,7R,8S,27S)-
| 59202-85-6 |
Septamycin, 27-hydroxy-, (27R)-
| 42617-35-6 |
Septamycin, monosodium salt
| 55924-40-8 |
Sagittaria sagittifolia Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family AlismaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 9,91,1971
| 55924-40-8 |
L-Serinamide, N(sup 2)-acetyl-N(sup 5)-formyl-N(sup5)-hydroxy-L-ornithyl-N-(3-(5-(3-(formylhydroxyamino)propyl)-3,6-dioxo-2-piperazinyl)propyl)-N-hydroxy-, (2S-cis)-, dihydrate
| 100157-28-6 |
L-Serinamide,N-(4-((7-((5-amino-5-carboxy-1-oxopentyl)amino)-2-carboxy-7-(formylamino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methoxy)-1-(3-((aminoiminome thyl)amino)propyl)-2-hydroxy-4-oxobutyl)-L-seryl-, hydrochloride, hydrate(1:1:2), (6R-(3(1S*,2R*),6-alpha,7-beta (R*)))-
| 99685-75-3 |
Serine, L-
| 56-45-1 |
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