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MSDS  : Sorbitan, monolaurate
CAS  : 1338-39-2
SYNONYMS  : * Emsorb 2515 * Radiasurf 7125 * Sorbitan, monododecanoate * Span 20
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WG2920000
CHEMICAL NAME : Sorbitan, monolaurate
CAS REGISTRY NUMBER : 1338-39-2
LAST UPDATED : 199710
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C18-H34-O6
MOLECULAR WEIGHT : 346.52
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Emsorb 2515
* Radiasurf 7125
* Sorbitan, monododecanoate
* Span 20

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 33600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 4(3),65,1985

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 720 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 112 gm/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 336 gm/kg/6W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3019 gm/kg/23W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2(1),59,1960

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1350 mg/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
120,1075,1954

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2000 mg/kg/25W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
Volume(issue)/page/year: 10,489,1963

*** REVIEWS ***

TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 4(3),65,1985

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83354
No. of Facilities: 869 (estimated)
No. of Industries: 4
No. of Occupations: 8
No. of Employees: 8185 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83354
No. of Facilities: 1627 (estimated)
No. of Industries: 11
No. of Occupations: 28
No. of Employees: 34995 (estimated)
No. of Female Employees: 22113 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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NAMECAS
Sonneratia apetala Buch.-Ham., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977 509-24-0
Siastatin A 54990-40-8
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Sophocarpine 6483-15-4
Sophocarpine, hydrobromide 78003-71-1
Sophora alopecuroides L., total alkaloids 78003-71-1
Sophora flavescens Ait., extract 78003-71-1
Sophora glauca Lesch., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974 78003-71-1
Sophora japonica L., extract 78003-71-1
Sophora secundiflora, seeds 78003-71-1
Sophora tonkinensis gagnep, root extract 78003-71-1
Sophora viciifolia, total alkaloids 78003-71-1
Sibbaldia cuneata Hornemann ex Edgew, extractSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 78003-71-1
Sophoridine 6882-68-4
Sopubia delphiniifolia (L.) G. Don, extractSUBSTANCE DEFINITION :Plant belonging to the family VitaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 6882-68-4
Sorangicin A 100415-25-6
Sorbaldehyde 142-83-6
Sorbaria sorbifolia A. Br., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 9,91,1971 142-83-6
Sorbic acid 110-44-1
Sorbic acid, aluminum salt 16899-72-2
Sorbic acid, copper salt 13991-87-2
Sorbic acid, cyclohexyl ester 16899-71-1
Sorbic acid, (2-dimethylamino)ethyl ester 16899-74-4
Sicilian sumac tannin 16899-74-4
Sorbic acid, ethyl ester 2396-84-1
Sorbic acid, glycidyl ester dimer 63915-78-6
Sorbic acid, potassium salt 590-00-1
Sorbic acid, potassium salt, (E,E)- 24634-61-5
Sorbic acid, propyl ester 10297-72-0
Sorbic acid, sodium salt 7757-81-5
Sorbic acid, zinc salt 5045-91-0
Sorbitan, dodecanoate 9-octadecenoate,poly(oxy-1,2-ethanediyl) derivs., (Z)- 53466-71-0
Sorbitan, monolaurate 1338-39-2
Sorbitan, monooleate 1338-43-8
Sida carpinifolia Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family MalvaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,696,1978 1338-43-8
Sorbitan, monooleate polyoxyethylene deriv. 9005-65-6
Sorbitan, monopalmitate 26266-57-9
Sorbitan, monopalmitate polyoxyethylene deriv. 9005-66-7
Sorbitan, monostearate 1338-41-6
Sorbitan, monostearate polyoxyethylene deriv. 9005-67-8
Sorbitan oleate 20 37318-79-9
Sorbitan oleate 30 37318-79-9
Sorbitan oleate 40 37318-79-9
Sorbitan, sesquioleate 8007-43-0
Sorbitan, trioleate polyoxyethylene deriv. 9005-70-3
Sida glutinosa Cav., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family MalvaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984 9005-70-3
Sorbitan, tris(9-octadecenoate), (Z)- 26266-58-0
Sorbitan, tristearate, polyoxyethylene derivs. 9005-71-4
Sorbitol, 1-deoxy-1-(4,5-dichloro-2-nitroanilino)- 108751-29-7
Sorbitol, 1,32,45,6-tri-O-methylene 3530-21-0

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