*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WG2920000
CHEMICAL NAME : Sorbitan, monolaurate
CAS REGISTRY NUMBER : 1338-39-2
LAST UPDATED : 199710
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C18-H34-O6
MOLECULAR WEIGHT : 346.52
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Emsorb 2515
* Radiasurf 7125
* Sorbitan, monododecanoate
* Span 20
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 33600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 4(3),65,1985
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 720 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 112 gm/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 336 gm/kg/6W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3019 gm/kg/23W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2(1),59,1960
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1350 mg/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
120,1075,1954
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2000 mg/kg/25W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
Volume(issue)/page/year: 10,489,1963
*** REVIEWS ***
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 4(3),65,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83354
No. of Facilities: 869 (estimated)
No. of Industries: 4
No. of Occupations: 8
No. of Employees: 8185 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83354
No. of Facilities: 1627 (estimated)
No. of Industries: 11
No. of Occupations: 28
No. of Employees: 34995 (estimated)
No. of Female Employees: 22113 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Sonneratia apetala Buch.-Ham., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 509-24-0 |
Siastatin A
| 54990-40-8 |
Sonneratia caseolaris Engl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SonneratiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 54990-40-8 |
Sophocarpine
| 6483-15-4 |
Sophocarpine, hydrobromide
| 78003-71-1 |
Sophora alopecuroides L., total alkaloids
| 78003-71-1 |
Sophora flavescens Ait., extract
| 78003-71-1 |
Sophora glauca Lesch., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 78003-71-1 |
Sophora japonica L., extract
| 78003-71-1 |
Sophora secundiflora, seeds
| 78003-71-1 |
Sophora tonkinensis gagnep, root extract
| 78003-71-1 |
Sophora viciifolia, total alkaloids
| 78003-71-1 |
Sibbaldia cuneata Hornemann ex Edgew, extractSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 78003-71-1 |
Sophoridine
| 6882-68-4 |
Sopubia delphiniifolia (L.) G. Don, extractSUBSTANCE DEFINITION :Plant belonging to the family VitaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 6882-68-4 |
Sorangicin A
| 100415-25-6 |
Sorbaldehyde
| 142-83-6 |
Sorbaria sorbifolia A. Br., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 9,91,1971
| 142-83-6 |
Sorbic acid
| 110-44-1 |
Sorbic acid, aluminum salt
| 16899-72-2 |
Sorbic acid, copper salt
| 13991-87-2 |
Sorbic acid, cyclohexyl ester
| 16899-71-1 |
Sorbic acid, (2-dimethylamino)ethyl ester
| 16899-74-4 |
Sicilian sumac tannin
| 16899-74-4 |
Sorbic acid, ethyl ester
| 2396-84-1 |
Sorbic acid, glycidyl ester dimer
| 63915-78-6 |
Sorbic acid, potassium salt
| 590-00-1 |
Sorbic acid, potassium salt, (E,E)-
| 24634-61-5 |
Sorbic acid, propyl ester
| 10297-72-0 |
Sorbic acid, sodium salt
| 7757-81-5 |
Sorbic acid, zinc salt
| 5045-91-0 |
Sorbitan, dodecanoate 9-octadecenoate,poly(oxy-1,2-ethanediyl) derivs., (Z)-
| 53466-71-0 |
Sorbitan, monolaurate
| 1338-39-2 |
Sorbitan, monooleate
| 1338-43-8 |
Sida carpinifolia Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family MalvaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,696,1978
| 1338-43-8 |
Sorbitan, monooleate polyoxyethylene deriv.
| 9005-65-6 |
Sorbitan, monopalmitate
| 26266-57-9 |
Sorbitan, monopalmitate polyoxyethylene deriv.
| 9005-66-7 |
Sorbitan, monostearate
| 1338-41-6 |
Sorbitan, monostearate polyoxyethylene deriv.
| 9005-67-8 |
Sorbitan oleate 20
| 37318-79-9 |
Sorbitan oleate 30
| 37318-79-9 |
Sorbitan oleate 40
| 37318-79-9 |
Sorbitan, sesquioleate
| 8007-43-0 |
Sorbitan, trioleate polyoxyethylene deriv.
| 9005-70-3 |
Sida glutinosa Cav., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family MalvaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984
| 9005-70-3 |
Sorbitan, tris(9-octadecenoate), (Z)-
| 26266-58-0 |
Sorbitan, tristearate, polyoxyethylene derivs.
| 9005-71-4 |
Sorbitol, 1-deoxy-1-(4,5-dichloro-2-nitroanilino)-
| 108751-29-7 |
Sorbitol, 1,32,45,6-tri-O-methylene
| 3530-21-0 |
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