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MSDS  : Silicic acid, beryllium zinc salt
CAS  : 39413-47-3
SYNONYMS  : * Beryllium zinc silicate * Zinc beryllium silicate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : VV9100000
CHEMICAL NAME : Silicic acid, beryllium zinc salt
CAS REGISTRY NUMBER : 39413-47-3
OTHER CAS REGISTRY NOS. : 63089-82-7
LAST UPDATED : 199712
DATA ITEMS CITED : 43
WISWESSER LINE NOTATION : BE ZN SI-O4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Beryllium zinc silicate
* Zinc beryllium silicate

*** HEALTH HAZARD DATA ***

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,519,1950

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
20,778,1966

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 17 mg(Be)/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53-
1966- Volume(issue)/page/year: 62,49,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 88,89,1969

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
JBSUAK Journal of Bone and Joint Surgery, British Volume. (10 Shattuck St.,
Boston, MA 02115) V.30- 1948- Volume(issue)/page/year: 36,543,1954

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 5,221,1946

*** REVIEWS ***

ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997

ACGIH TLV-TWA 0.002 mg(Be)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 1,17,1972

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 23,143,1980

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993

IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993

IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993

TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971

*** U.S. STANDARDS AND REGULATIONS ***

OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993

OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-DENMARK:TWA 0.001 mg(Be)/m3;Carcinogen JAN 1993

OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993

OEL-FRANCE:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-GERMANY;Carcinogen JAN 1993

OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993

OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993

OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993

OEL-POLAND:TWA 0.001 mg(Be)/m3 JAN 1993

OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993

OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993

OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993

OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Silicate, soapstoneSUBSTANCE DEFINITION :Containing less than 1% crystalline silicaREFERENCE :FEREAC Federal Register. (U.S. Government Printing Office, Supt. ofDocuments, Washington, DC 20402) V.1- 1936- 65997-15-1
Silicic acid 7699-41-4
Silicic acid (ortho) 10193-36-9
Silicic acid (polyortho) 1343-98-2
Silicic acid, aluminum magnesium salt 1327-43-1
Silicic acid, beryllium salt 15191-85-2
Silicic acid, beryllium zinc salt 39413-47-3
SF-1508 56378-68-8
Silicic acid, calcium salt 1344-95-2
Silicic acid (H2SiO3), calcium salt (11) 10101-39-0
Silicic acid, 2-chloroethyl ester 10101-39-0
Silicic acid (H2SiO3), disodium salt 6834-92-0
Silicic acid, 2-ethylbutyl ester 68037-57-0
Silicic acid, methyl ester 12002-26-5
Silicic acid, tetra(2-ethylbutyl) ester 78-13-7
Silicic acid, tetraethyl ester 78-10-4
Silicic acid, tetra(2-fluoroethyl) ester 650-00-0
Silicic acid, tetrakis(2-chloroethyl) ester 18290-84-1
SF-1739 61991-01-3
Silicic acid (H2SiO4), tetrakis(1-methylpropyl) ester 5089-76-9
Silicic acid, tetramethyl ester 681-84-5
Silicon 7440-21-3
Silicon(1+),(1-(bis(2-hydroxyethyl)amino)-2-propanolato(3-)-N,O,O',O") (ethylmethylsulfonium eta-methylide)-, iodide,(TB-5-34)- 67349-10-4
Silicon carbide 409-21-2
Silicon chloride 10026-04-7
Silicon chrome 11133-78-1
Silicon(1+), (diethylsulfoniumeta-methylide)((1,1',1"-nitrilotris(2-propanolato))(3-)- N,O,O',O")-, bromide, (TB-5-23) 67366-36-3
Silicon(1+), ((1,1-dimethylethyl)methylsulfoniumeta-methylide)((2,2',2"-nitrilotris(ethanolato))(3-)-N,O,O',O")-, iodide, (TB-5-23)- 67349-11-5
Silicon dioxide, hydrate 67349-11-5
SF 3024-B20-KOSUBSTANCE DEFINITION :Phenol resin which is mixture of oligomersREFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene andOccupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)V.1-36, 1957-1992. For publisher information, see MTPEEIVolume(issue)/page/year: 28(7),53,1984 67349-11-5
Silicon,(3,3,4,4,5,5,6,6,7,7,8,8-dodecafluoro-1-iodooctyl)((2,2'2,''-nitrilotris(e thanolato))(3-)-N,O,O',O'')-,(TB-5-23)- 135798-16-2
Silicon,(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-iododecyl)((2,2',2 ''-nitrilotris(ethanolato(3-)-N,O,O',O'')-, (TB-5-23)- 135798-18-4
Silicon,(3,3,4,4,5,5,5-heptafluoro-1-iodopentyl)((2,2',2''-nitrilotris(ethanolato) )(3-)- N,O,O',O'')-, (TB-5-23)- 112341-58-9
Silicon,(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-hexadecafluoro-1-iododecyl)((2,2',2''-n itrilotris(ethanolato))(3-)-N,O,O',O'')-, (TB-5-23)- 135798-17-3
Silicon,((2,2',2''-nitrilotris(ethanolato))(3-)-N,O,O',O'')(3,3,4,4,5,5,6,6,6-nona fluoro-1- iodohexyl)-,(TB-5-23)- 135798-15-1
Silicon,((2,2',2''-nitrilotris(ethanolato))(3-)-N,O,O',O'')(3,3,4,4,5,5,6,6-octafl uoro-1- iodohexyl)-, (TB-5-23)- 135798-14-0
Silicon,((2,2',2''-nitrilotris(ethanolato))(3-)-N,O,O',O'')(3,3,4,4,5,5,6,6,7,7,8, 8,8-tridecafluoro-1-iodooctyl)-, (TB-5-23)- 135829-02-6
Silicon,((2,2',2''-nitrilotris(ethanolato))(3-)-N,O,O',O'')(3,3,3-trifluoro-1-iodo propyl)-, (TB-5-23)- 112341-57-8
Silicone 7158 112341-57-8
Silicone antifoam sag-47 112341-57-8
SF-1540 A 71329-58-3
Silicone antifoam sag-100 71329-58-3
Silicone C-25 71329-58-3
Silicone fluid L-43 71329-58-3
Silicone L-31 71329-58-3
Silicone L-42 (oil) 71329-58-3
Silicone L-45 63148-62-9
Silicone L-75 63148-53-8
Silicone L-76 63148-53-8
Silicone L-77 63148-53-8

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