*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VU9990000
CHEMICAL NAME : Shosaiko-TO
CAS REGISTRY NUMBER : 63364-01-2
LAST UPDATED : 199403
DATA ITEMS CITED : 8
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Sho-saiko-To
* Shosaikoto-Go-keishika-shakuyakuto
* Shosaiko-toi
* TJ-9
* Xiao-Chai-Hu-Tang
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,793,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1569 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,793,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >6 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 21,5651,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,793,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,793,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,793,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 912 gm/kg/1Y-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 39,405,1990
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : >11 gm/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 44,659,1992
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
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Solanum elaeagnifolium Cav., fruitSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,UK) V.1- 1962-
| 104619-04-7 |
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Solanum erianthum D. Don, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 104619-04-7 |
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Solanum ferox Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984
| 104619-04-7 |
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Solanum hispidum Pers., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 104619-04-7 |
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Solanum incanum Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 104619-04-7 |
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Solanum indicum Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 104619-04-7 |
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Solanum indicum Linn. var. multiflora (roth ex Roem.& Schult.) Cl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 104619-04-7 |
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Shorea robusta Gaertn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family DipterocarpaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984
| 104619-04-7 |
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Solanum laciniatum Ait., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: , 28,619,1990
| 104619-04-7 |
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Solanum melongena Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 104619-04-7 |
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Solanum nigrum L., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:27,163,1989
| 104619-04-7 |
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Solanum pseudocapsicum L., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 104619-04-7 |
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Solanum pubescens Willd., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 104619-04-7 |
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Solanum seaforthianum Ander., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 104619-04-7 |
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Solanum sisymbrifolium Lam., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,228,1978
| 104619-04-7 |
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Solanum subtruncatum Wall., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 104619-04-7 |
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Solanum torvum Sw., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,1255 Howard St., San Francisco, CA 94103) V.6- 1958-Volume(issue)/page/year: 13,882,1965
| 104619-04-7 |
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Solanum trilobatum Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 104619-04-7 |
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Shosaiko-TO
| 63364-01-2 |
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Solanum tuberosum, berries
| 63364-01-2 |
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Solanum verbascifolium L., extractSUBSTANCE DEFINITION :Plant belonging to the family SolanaceaeREFERENCE :JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of GreatBritain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-Volume(issue)/page/year: 17,98,1965
| 63364-01-2 |
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Solanum xanthocarpum, seed extractSUBSTANCE DEFINITION :Crude alcoholic extract from plant belonging to the family SolanaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 63364-01-2 |
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Solasod-5-en-3-beta-ol
| 126-17-0 |
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Solasonine
| 19121-58-5 |
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Solidago virga-aurea Linn., extract
| 85117-06-2 |
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Solidago virgaurea alpestris L., flower extract
| 85117-06-2 |
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Solidago virgaurea alpestris L., leaf extract
| 85117-06-2 |
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Solidago virgaurea L., flower extract
| 85117-06-2 |
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Solidago virgaurea L., leaf extract
| 85117-06-2 |
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Sho-seiryu-toSUBSTANCE DEFINITION :A mixture of 8 herbal medicines, i.e., Pinelliae Tuber, Glycyrrhizae Radix,Cinnamomi Cortex, Schisandrae Fructus, Asiasari Radix, Paeoniae Radix,Ephedrae Herba and Zingiberis Siccatum Rhizoma (6:3:3:3:3:3:3:3)REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu SaiensuShuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
| 85117-06-2 |
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Solidago virgaurea Linn. var. pubescens (wall.)Clarke, extractSUBSTANCE DEFINITION :Plant belonging to the family AsteraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,487,1984
| 85117-06-2 |
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Soltrol 130
| 85117-06-2 |
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Solvent naphtha
| 64742-94-5 |
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Solvent naphtha (petroleum), light aromatic
| 64742-95-6 |
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Solvent naphtha, petroleum, medium aliph.
| 64742-88-7 |
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Solvent refined coal-I, process solvent
| 64742-88-7 |
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Solvent refined coal-II, heavy distillateSUBSTANCE DEFINITION :High-boiling (550-850 degrees F) liquid material from solvent refined coalprocessesREFERENCE :TJADAB Teratology, The International Journal of Abnormal Development. (AlanR. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
| 64742-88-7 |
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Somalin
| 12708-27-9 |
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Somatoliberin (human pancreatic islet), acetate
| 12708-27-9 |
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Somatostatin
| 51110-01-1 |
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Shuteria vestita Wight & Arn., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 51110-01-1 |
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Somatostatin (sheep),1-de-L-alanine-2-deglycine-4-L-histidine-5-L-histidine-8-D-tryptophan-
| 68463-41-2 |
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Somatotropin (human)
| 12629-01-5 |
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Somatotropin (sheep)
| 37267-05-3 |
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Somatotropin (human), N-L-methionyl-
| 82030-87-3 |
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Sonchus arvensis Linn, extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 82030-87-3 |
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Sonchus asper Hill, extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 82030-87-3 |
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Sonchus oleraceus Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 82030-87-3 |
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Songorine
| 509-24-0 |
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Sonneratia alba J.Sm., extractSUBSTANCE DEFINITION :Plant belonging to the family SonneratiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 509-24-0 |
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