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MSDS  : Asbestos
CAS  : 1332-21-4
SYNONYMS  : * Amianthus * Amosite (Obs.) * Amphibole * Asbest * Asbestos * Asbestos fiber * Asbestos fibre * Fibrous grunerite * NCI C08991
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : CI6475000
CHEMICAL NAME : Asbestos
CAS REGISTRY NUMBER : 1332-21-4
LAST UPDATED : 199712
DATA ITEMS CITED : 41
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Amianthus
* Amosite (Obs.)
* Amphibole
* Asbest
* Asbestos
* Asbestos fiber
* Asbestos fibre
* Fibrous grunerite
* NCI C08991

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 1.2 fb/cc/19Y-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - pleural effusion
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - sputum
REFERENCE :
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740
Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:
104,576,1971

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75,
1903-71. For publisher information, see JCROD7. Volume(issue)/page/year:
62,561,1958

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 24,61,1983

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 mg/plate
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 177,343,1984

*** REVIEWS ***

ACGIH TLV-Confirmed human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-STEL 2 fibers/cc, longer than 5 um
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 2,17,1973

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 2,17,1973

IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 14,11,1977

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 14,11,1977

IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,106,1987

TOXICOLOGY REVIEW
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 64,1435,1975

TOXICOLOGY REVIEW
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 57,462,1976

TOXICOLOGY REVIEW
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
Volume(issue)/page/year: 15,808,1973

TOXICOLOGY REVIEW
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 39,1792,1977

TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year:
5,55,1970

TOXICOLOGY REVIEW
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays,
International Symposium, 1974," Karbe, E., and J.F. Park, eds.,
Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,92,1974

TOXICOLOGY REVIEW
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene,
Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed.
Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.
Volume(issue)/page/year: 166,113,1978

TOXICOLOGY REVIEW
NOSYBW Nobel Symposium. (Nobel Foundation, Sturegatan 14, S-11436
Stockholm, Sweden) No.1- 1966- Volume(issue)/page/year: 40,311,1977

TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
12,102,1969

TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-691001

TOXICOLOGY REVIEW
CNDIBJ Cahiers de Notes Documentaires. (Institut National de Recherche et
de Securite, 30 rue Olivier Noyer, 75680 Paris Cedex, 14, France) No.1-
1955- Volume(issue)/page/year: 85,559,1976

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 5 fb/cc (fb > 5 um)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,33,1973

OSHA PEL (Construc):see CFR 29,1926.58
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.2 f/cc
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA-CANCER AND LUNG DISEASE HAZARD
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1001,1991

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-FRANCE:TWA 1 fiber/ml JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ASBESTOS-air:100M TWA 0.1 fb/cc in a 400L air sample
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 90310
No. of Facilities: 30863 (estimated)
No. of Industries: 154
No. of Occupations: 117
No. of Employees: 449904 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 90310
No. of Facilities: 15617 (estimated)
No. of Industries: 81
No. of Occupations: 86
No. of Employees: 215265 (estimated)
No. of Female Employees: 9727 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Negative: TRP reversion

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH CURRENT INTELLIGENCE BULLETIN 5, 1975

NIOSH Analytical Method, 1994: Asbestos (bulk) by PLM, 9002; by PCM, 7400;
by TEM, 7402

NTP 7th Annual Report on Carcinogens, 1992 : known to be carcinogenic


*** END OF RECORD ***
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