*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YR1575000
CHEMICAL NAME : Uracil, 2-thio-
CAS REGISTRY NUMBER : 141-90-2
OTHER CAS REGISTRY NOS. : 156-82-1
LAST UPDATED : 199701
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C4-H4-N2-O-S
MOLECULAR WEIGHT : 128.16
WISWESSER LINE NOTATION : T6MYMVJ BUS
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Antagothyroid
* Antagothyroil
* Deracil
* 2,3-Dihydro-2-thioxo-4(1H)-pyrimidinone
* 6-Hydroxy-2-mercaptopyrimidine
* 4-Hydroxy-2(1H)-pyrimidinethione
* 2-Mercapto-4-hydroxypyrimidine
* 2-Mercapto-4-pyrimidinol
* 2-Mercapto-4-pyrimidone
* 2-Mercapto-4(1H)-pyrimidinone
* 2-Mercaptopyrimid-4-one
* Nobilen
* 4-Pyrimidinol, 2-mercapto-
* 2-Thio-6-oxypyrimidine
* 2-Thio-1,3-pyrimidin-4-one
* Thiouracil
* 2-Thiouracil
* 6-Thiouracil
* Tiouracyl
* TU
* 2-TU
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 97,478,1949
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 44,56,1955
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2100 mg/kg/4W-C
TOXIC EFFECTS :
Endocrine - changes in thyroid weight
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 97,349,1949
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg/14W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid weight (goiter)
Tumorigenic - increased incidence of tumors in susceptible strains
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 6,111,1953
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 184 gm/kg/73W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 113,493,1963
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 484 mg/kg
SEX/DURATION : female 1-26 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,1281,1953
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 924 mg/kg
SEX/DURATION : female 26-41 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
JCENA4 Journal of Clinical Endocrinology. (Springfield, IL) V.1-11,
1941-51. For publisher information, see JCEMAZ. Volume(issue)/page/year:
7,767,1947
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1600 mg/kg
SEX/DURATION : female 1-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
45,389,1949
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 22750 mg/kg
SEX/DURATION : female 91 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.1- 1906/08- Volume(issue)/page/year: 109,318,1951
** MUTATION DATA **
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 mmol/L
REFERENCE :
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see
EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
Volume(issue)/page/year: 31,11,1979
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,85,1974
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,85,1974
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0277
No. of Facilities: 6 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 1776 (estimated)
No. of Female Employees: 634 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Uracil, 5-fluoro-3-(tetrahydro-2-furyl)-
| 63901-83-7 |
Uracil, 5-fluoro-1-(tetrahydro-2-furyl)- mixt. withuracil (1:4)
| 74578-38-4 |
Uracil, 4-hydrazino-2-thio-
| 63981-09-9 |
Uracil, 5-hydroperoxymethyl-
| 33499-50-2 |
1-alpha-H,5-alpha-H-Tropanium,3-hydroxy-8-(p-pentylbenzyl)-, bromide,alpha-phenylcyclohexaneacetate
| 102433-00-1 |
Uracil, 5-(hydroxymethyl)-
| 4433-40-3 |
Uracil, 5-(hydroxymethyl)-6-methyl-
| 147-61-5 |
Uracil, 6-((p-hydroxyphenyl)azo)-
| 29050-86-0 |
Uracil, 5-iodo-
| 696-07-1 |
Uracil, 5-iodo-2-thio-
| 5984-97-4 |
Uracil, 5-iodo-2-thio-, sodium salt
| 3565-15-9 |
Uracil lactone
| 3565-15-9 |
Uracil, methyl-
| 27942-00-3 |
Uracil, 6-methyl-
| 626-48-2 |
Uracil, 6-methyl-5-phenylazo-
| 15020-66-3 |
1-alpha-H,5-alpha-H-Tropanium,3-alpha-hydroxy-8-(p-pentylbenzyl)-, bromide,(+-)-tropate
| 102433-01-2 |
Uracil, 6-methyl-5-propyl-
| 102613-26-3 |
Uracil, 6-methyl-5-propyl-2-thio-
| 51482-41-8 |
Uracil, 6-methyl-2-thio-
| 56-04-2 |
Uracil, 6-propyl-2-thio-
| 51-52-5 |
Uracil, 6-propyl-2-thio-, and iodine
| 51-52-5 |
Uracil, 1-beta-D-ribofuranosyl-
| 58-96-8 |
Uracil, 2-thio-
| 141-90-2 |
Uracil, 5-(trifluoromethyl)-
| 54-20-6 |
Uracil, 3,5,6-trimethyl-
| 31408-09-0 |
Uranic acid, diammonium salt
| 7783-22-4 |
1-alpha-H,5-alpha-H-Tropanium,8-(p-butylbenzyl)-3-hydroxy-, bromide, benzoate(ester)
| 102432-88-2 |
1-alpha-H,5-alpha-H-Tropanium, 3-hydroxy-8-pentyl-,bromide, benzilate
| 74051-35-7 |
Uranic acid, diammonium salt, hydrate
| 28347-83-3 |
Uraninite
| 1317-99-3 |
Uranium
| 7440-61-1 |
Uranium, bis(acetato)dioxo-, dihydrate
| 6159-44-0 |
Uranium, bis(acetato-O)dioxo-, (T-4)
| 541-09-3 |
Uranium, bis(nitrato-O,O')dioxo-
| 10102-06-4 |
Uranium, bis(nitrato-O,O')dioxo-, (OC-6-11)-
| 36478-76-9 |
Uranium, bis(nitrato)dioxo-, hexahydrate
| 13520-83-7 |
Uranium(IV) chloride
| 10026-10-5 |
Uranium(6+), dichlorodioxy-
| 7791-26-6 |
1-alpha-H,5-alpha-H-Tropanium, 3-hydroxy-8-pentyl-,bromide, 4-hydroxy-2-phenylbutanoate
| 74051-36-8 |
Uranium, difluorodioxo-
| 13536-84-0 |
Uranium floride
| 10049-14-6 |
Uranium fluoride
| 7783-81-5 |
Uranium ore
| 53125-22-7 |
Uranium oxide
| 1344-59-8 |
Uraria lagopoides DC., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 1344-59-8 |
Uraria picta Desv., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 1344-59-8 |
Urea
| 57-13-6 |
Urea, 1-(5-acenaphthenyl)-3-(2-chloroethyl)-
| 102613-27-4 |
Urea,3-(4-acetoxycyclohexyl)-1-(2-chloroethyl)-1-nitroso-
| 32319-91-8 |
1-alpha-H,5-alpha-H-Tropanium,3-beta-hydroxy-8-(p-phenylbenzyl)-, bromide, benzoate
| 32319-91-8 |
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