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MSDS  : Tyrosine, L-
CAS  : 60-18-4
SYNONYMS  : * Tyrosine * L-Tyrosine * L-p-Tyrosine * p-Tyrosine * (S)-Tyrosine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : YP2275600
CHEMICAL NAME : Tyrosine, L-
CAS REGISTRY NUMBER : 60-18-4
LAST UPDATED : 199709
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C9-H11-N-O3
MOLECULAR WEIGHT : 181.21
WISWESSER LINE NOTATION : QVYZ1R DQ
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Tyrosine
* L-Tyrosine
* L-p-Tyrosine
* p-Tyrosine
* (S)-Tyrosine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 97,1117,1977

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 42 gm/kg/2W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Biochemical - Metabolism (Intermediary) - amino acids (including renal
excretion)
Related to Chronic Data - death
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 95,535,1968

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 20750 mg/kg
SEX/DURATION : female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 30,518,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5 gm/kg
SEX/DURATION : female 11-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PHBHA4 Physiology and Behavior. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1966- Volume(issue)/page/year:
55,607,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3500 mg/kg
SEX/DURATION : female 15-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1966- Volume(issue)/page/year: 635,96,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 150 mg/kg
SEX/DURATION : female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4,
1969-71(?). Discontinued. For publisher information, see BIREBV.
Volume(issue)/page/year: 20(Suppl 1),133A,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 3 gm/kg
SEX/DURATION : female 29-31 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BINEAA Biologia Neonatorum. (Basel, Switzerland) V.1-14, 1956-69. For
publisher information, see BNEOBV. Volume(issue)/page/year: 12,282,1968

** MUTATION DATA **

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81869
No. of Facilities: 133 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 1421 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81869
No. of Facilities: 275 (estimated)
No. of Industries: 3
No. of Occupations: 12
No. of Employees: 14731 (estimated)
No. of Female Employees: 12371 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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