*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YR0700000
CHEMICAL NAME : Uracil, 6-methyl-
CAS REGISTRY NUMBER : 626-48-2
LAST UPDATED : 199701
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C5-H6-N2-O2
MOLECULAR WEIGHT : 126.13
WISWESSER LINE NOTATION : T6MVMVJ F1
COMPOUND DESCRIPTOR : Tumorigen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 6-Methyl-2,4(1H,3H)-pyrimidinedione
* 4-Methyluracil
* 6-Methyluracil
* Pseudothymine
* 2,4(1H,3H)-Pyrimidinedione, 6-methyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 64500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland
Volume(issue)/page/year: 03FEB1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 44,56,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 27,112,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 48,186,1985
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18 gm/kg/52W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 8(10),49,1962
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2 gm/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 66,1382,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 20 mg/kg
SEX/DURATION : female 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological
Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information,
see IJEBA6. Volume(issue)/page/year: 19,264,1960
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1624
No. of Facilities: 89 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 293 (estimated)
No. of Female Employees: 109 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Uracil, 5-fluoro-3-(tetrahydro-2-furyl)-
| 63901-83-7 |
Uracil, 5-fluoro-1-(tetrahydro-2-furyl)- mixt. withuracil (1:4)
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Uracil, 4-hydrazino-2-thio-
| 63981-09-9 |
Uracil, 5-hydroperoxymethyl-
| 33499-50-2 |
1-alpha-H,5-alpha-H-Tropanium,3-hydroxy-8-(p-pentylbenzyl)-, bromide,alpha-phenylcyclohexaneacetate
| 102433-00-1 |
Uracil, 5-(hydroxymethyl)-
| 4433-40-3 |
Uracil, 5-(hydroxymethyl)-6-methyl-
| 147-61-5 |
Uracil, 6-((p-hydroxyphenyl)azo)-
| 29050-86-0 |
Uracil, 5-iodo-
| 696-07-1 |
Uracil, 5-iodo-2-thio-
| 5984-97-4 |
Uracil, 5-iodo-2-thio-, sodium salt
| 3565-15-9 |
Uracil lactone
| 3565-15-9 |
Uracil, methyl-
| 27942-00-3 |
Uracil, 6-methyl-
| 626-48-2 |
Uracil, 6-methyl-5-phenylazo-
| 15020-66-3 |
1-alpha-H,5-alpha-H-Tropanium,3-alpha-hydroxy-8-(p-pentylbenzyl)-, bromide,(+-)-tropate
| 102433-01-2 |
Uracil, 6-methyl-5-propyl-
| 102613-26-3 |
Uracil, 6-methyl-5-propyl-2-thio-
| 51482-41-8 |
Uracil, 6-methyl-2-thio-
| 56-04-2 |
Uracil, 6-propyl-2-thio-
| 51-52-5 |
Uracil, 6-propyl-2-thio-, and iodine
| 51-52-5 |
Uracil, 1-beta-D-ribofuranosyl-
| 58-96-8 |
Uracil, 2-thio-
| 141-90-2 |
Uracil, 5-(trifluoromethyl)-
| 54-20-6 |
Uracil, 3,5,6-trimethyl-
| 31408-09-0 |
Uranic acid, diammonium salt
| 7783-22-4 |
1-alpha-H,5-alpha-H-Tropanium,8-(p-butylbenzyl)-3-hydroxy-, bromide, benzoate(ester)
| 102432-88-2 |
1-alpha-H,5-alpha-H-Tropanium, 3-hydroxy-8-pentyl-,bromide, benzilate
| 74051-35-7 |
Uranic acid, diammonium salt, hydrate
| 28347-83-3 |
Uraninite
| 1317-99-3 |
Uranium
| 7440-61-1 |
Uranium, bis(acetato)dioxo-, dihydrate
| 6159-44-0 |
Uranium, bis(acetato-O)dioxo-, (T-4)
| 541-09-3 |
Uranium, bis(nitrato-O,O')dioxo-
| 10102-06-4 |
Uranium, bis(nitrato-O,O')dioxo-, (OC-6-11)-
| 36478-76-9 |
Uranium, bis(nitrato)dioxo-, hexahydrate
| 13520-83-7 |
Uranium(IV) chloride
| 10026-10-5 |
Uranium(6+), dichlorodioxy-
| 7791-26-6 |
1-alpha-H,5-alpha-H-Tropanium, 3-hydroxy-8-pentyl-,bromide, 4-hydroxy-2-phenylbutanoate
| 74051-36-8 |
Uranium, difluorodioxo-
| 13536-84-0 |
Uranium floride
| 10049-14-6 |
Uranium fluoride
| 7783-81-5 |
Uranium ore
| 53125-22-7 |
Uranium oxide
| 1344-59-8 |
Uraria lagopoides DC., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 1344-59-8 |
Uraria picta Desv., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 1344-59-8 |
Urea
| 57-13-6 |
Urea, 1-(5-acenaphthenyl)-3-(2-chloroethyl)-
| 102613-27-4 |
Urea,3-(4-acetoxycyclohexyl)-1-(2-chloroethyl)-1-nitroso-
| 32319-91-8 |
1-alpha-H,5-alpha-H-Tropanium,3-beta-hydroxy-8-(p-phenylbenzyl)-, bromide, benzoate
| 32319-91-8 |
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