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MSDS  : 1,2-Benzenedicarboxylic acid, di-2-propenyl ester
CAS  : 131-17-9
SYNONYMS  : * Dapon 35 * Dapon R * Diallylester kyseliny ftalove * Diallyl phthalate * NCI-C50657 * Phthalic acid, diallyl ester * o-Phthalic acid, diallyl ester
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : CZ4200000
CHEMICAL NAME : 1,2-Benzenedicarboxylic acid, di-2-propenyl ester
CAS REGISTRY NUMBER : 131-17-9
BEILSTEIN REFERENCE NO. : 1880877
REFERENCE : 4-09-00-03188 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 28
MOLECULAR FORMULA : C14-H14-O4
MOLECULAR WEIGHT : 246.28
WISWESSER LINE NOTATION : 1U2OVR BVO2U1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Dapon 35
* Dapon R
* Diallylester kyseliny ftalove
* Diallyl phthalate
* NCI-C50657
* Phthalic acid, diallyl ester
* o-Phthalic acid, diallyl ester

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Moderate
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521089

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Mild
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 656 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-284,1985

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5200 mg/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521092

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521092

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1904,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521092

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 5,191,1946

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5600 mg/kg/14D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-284,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 gm/kg/13W-I
TOXIC EFFECTS :
Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-284,1985

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 52 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 65,271,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 156 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 65,271,1986

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 67200 ug/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 300 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
25,302,1995

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 67200 ug/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 200 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 160 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987

*** REVIEWS ***

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
54,1,1975

TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 4,3,1973

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 23180
No. of Facilities: 390 (estimated)
No. of Industries: 15
No. of Occupations: 27
No. of Employees: 8596 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 23180
No. of Facilities: 484 (estimated)
No. of Industries: 11
No. of Occupations: 18
No. of Employees: 8784 (estimated)
No. of Female Employees: 2027 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis Studies (gavage);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-284,85

NTP Carcinogenesis Studies (gavage);inadequate studies:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-242,83


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
1,4-Benzenedicarboxylic acid, dioctyl ester 4654-26-6
1,2-Benzenedicarboxylic acid, di-2-propenyl ester 131-17-9
1,3-Benzenedicarboxylic acid, di-2-propenyl ester,homopolymer 25035-78-3
1,3-Benzenedicarboxylic acid, di-2-propenyl ester 1087-21-4
Benzenearsonic acid,p-((p-(hexadecylamino)phenyl)azo)- 1087-21-4
1,2-Benzenedicarboxylic acid, esters, dimethyl ester,mixt. with pentachlorophenol and 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxybenzene) 116189-57-2
1,3-Benzenedicarboxylic acid, 5-hydroxy- 618-83-7
1,3-Benzenedicarboxylic acid, 4-hydroxy-, 3-ethyl1-methyl ester 618-83-7
1,3-Benzenedicarboxylic acid, 4-hydroxy-,1-(1-methylethyl) 3-methyl ester 618-83-7
1,2-Benzenedicarboxylic acid, 3-methoxy-, dihydrazide 103724-37-4
1,2-Benzenedicarboxylic acid, monooctyl ester 5393-19-1
1,2-Benzenedicarboxylic acid, mono(phenylmethyl)ester 2528-16-7
1,2-Benzenedicarboxylic acid, monopotassium salt 877-24-7
1,3-Benzenedicarboxylic acid, 5-nitro-,bis(1-methylethyl) ester 10552-74-6
1,3-Benzenedicarboxylic acid, 5-nitro-, dimethylester 13290-96-5
Benzenearsonic acid, p-((p-(hexylamino)phenyl)azo)- 13290-96-5
1,4-Benzenedicarboxylic acid, polymer with1,4-benzenediamine 25035-37-4
Benzene-1,3-dicarboxylic acid, 5-sulfo- 22326-31-4
1,4-Benzenedicarboxylic acid, 2,3,5,6-tetrachloro- 2136-79-0
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Benzene, p-dichloro- 106-46-7
Benzene, dichlorocyclohexyl- 59330-98-2
Benzene, 1,4-dichloro-2,5-dimethoxy- 2675-77-6
Benzene, 1,2-dichloro-4,5-dinitro- 6306-39-4
Benzene, 1,5-dichloro-2,3-dinitro- 28689-08-9
Benzenearsonic acid, p-hydroxy- 98-14-6
Benzene, dichlorodinitro-, and dichloronitrobenzene 98-14-6
Benzene, (((1,2-dichloroethenyl)thio)methyl)- 91085-62-0
Benzene,1-(2,2-dichloro-1-(4-ethoxyphenyl)ethyl)-4-propoxy- 62897-64-7
Benzene,1-(2,2-dichloro-1-(4-ethoxyphenyl)propyl)-4-propoxy- 62897-69-2
Benzene, dichloroethyl- 1331-29-9
Benzene, 1,1'-(2,2-dichloroethylidene)bis(4-ethoxy- 7388-32-1
Benzene, 1,1'-(2-dichloroethylidene)bis(4-methoxy- 7388-31-0
Benzene, (dichloromethyl)- 98-87-3
Benzene, 1-(dichloromethyl)-3-phenoxy- 53874-68-3
Benzene, 1,2-dichloro-4-(4-(methylsulfonyl)phenoxy)- 83642-20-0
Benzenearsonic acid, 4-hydroxy-3-nitro- 121-19-7
Benzene, 1,2-dichloro-3-nitro- 3209-22-1
Benzene, 1,2-dichloro-4-nitro- 99-54-7
Benzene, 1,4-dichloro-2-nitro- 89-61-2
Benzene, 2,4-dichloro-1-nitro- 611-06-3
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Benzene,1-((2-(3,4-dichlorophenyl)-2-methylbutoxy)methyl)-3-phenoxy- 80844-04-8
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Benzene,4-((2-(3,5-dichlorophenyl)-2-methylpropoxy)methyl)-1-fluoro-2-phenoxy- 83493-32-7
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-(4-methoxyphenoxy)- 80843-93-2
Benzenearsonic acid, 4-(1-(2-hydroxy)propoxy)- 5411-08-5
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