*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CZ5075000
CHEMICAL NAME : Benzene, (dichloromethyl)-
CAS REGISTRY NUMBER : 98-87-3
BEILSTEIN REFERENCE NO. : 1099407
REFERENCE : 4-05-00-00817 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C7-H6-Cl2
MOLECULAR WEIGHT : 161.03
WISWESSER LINE NOTATION : GYGR
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzal chloride
* Benzyl dichloride
* Benzylene chloride
* Chlorobenzal
* Chlorure de benzylidene
* (Dichloromethyl)benzene
* alpha,alpha-Dichlorotoluene
* RCRA waste number U017
* Toluene, alpha,alpha-dichloro-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3249 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 61 ppm/2H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 29,65,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2462 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 32 ppm/2H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 29,65,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 40(1),92,1975
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 210 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(3),6,1986
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9200 mg/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
72,655,1981
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35200 mg/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
72,655,1981
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 600 nmol/plate/20M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,143,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 600 nmol/plate/20M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,143,1978
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 31 umol/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,143,1978
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 29,65,1982
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 29,65,1982
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FINLAND;Carcinogen JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine
reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
1,4-Benzenedicarboxylic acid, dioctyl ester
| 4654-26-6 |
|
1,2-Benzenedicarboxylic acid, di-2-propenyl ester
| 131-17-9 |
|
1,3-Benzenedicarboxylic acid, di-2-propenyl ester,homopolymer
| 25035-78-3 |
|
1,3-Benzenedicarboxylic acid, di-2-propenyl ester
| 1087-21-4 |
|
Benzenearsonic acid,p-((p-(hexadecylamino)phenyl)azo)-
| 1087-21-4 |
|
1,2-Benzenedicarboxylic acid, esters, dimethyl ester,mixt. with pentachlorophenol and 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxybenzene)
| 116189-57-2 |
|
1,3-Benzenedicarboxylic acid, 5-hydroxy-
| 618-83-7 |
|
1,3-Benzenedicarboxylic acid, 4-hydroxy-, 3-ethyl1-methyl ester
| 618-83-7 |
|
1,3-Benzenedicarboxylic acid, 4-hydroxy-,1-(1-methylethyl) 3-methyl ester
| 618-83-7 |
|
1,2-Benzenedicarboxylic acid, 3-methoxy-, dihydrazide
| 103724-37-4 |
|
1,2-Benzenedicarboxylic acid, monooctyl ester
| 5393-19-1 |
|
1,2-Benzenedicarboxylic acid, mono(phenylmethyl)ester
| 2528-16-7 |
|
1,2-Benzenedicarboxylic acid, monopotassium salt
| 877-24-7 |
|
1,3-Benzenedicarboxylic acid, 5-nitro-,bis(1-methylethyl) ester
| 10552-74-6 |
|
1,3-Benzenedicarboxylic acid, 5-nitro-, dimethylester
| 13290-96-5 |
|
Benzenearsonic acid, p-((p-(hexylamino)phenyl)azo)-
| 13290-96-5 |
|
1,4-Benzenedicarboxylic acid, polymer with1,4-benzenediamine
| 25035-37-4 |
|
Benzene-1,3-dicarboxylic acid, 5-sulfo-
| 22326-31-4 |
|
1,4-Benzenedicarboxylic acid, 2,3,5,6-tetrachloro-
| 2136-79-0 |
|
Benzene, m-dichloro-
| 541-73-1 |
|
Benzene, o-dichloro-
| 95-50-1 |
|
Benzene, p-dichloro-
| 106-46-7 |
|
Benzene, dichlorocyclohexyl-
| 59330-98-2 |
|
Benzene, 1,4-dichloro-2,5-dimethoxy-
| 2675-77-6 |
|
Benzene, 1,2-dichloro-4,5-dinitro-
| 6306-39-4 |
|
Benzene, 1,5-dichloro-2,3-dinitro-
| 28689-08-9 |
|
Benzenearsonic acid, p-hydroxy-
| 98-14-6 |
|
Benzene, dichlorodinitro-, and dichloronitrobenzene
| 98-14-6 |
|
Benzene, (((1,2-dichloroethenyl)thio)methyl)-
| 91085-62-0 |
|
Benzene,1-(2,2-dichloro-1-(4-ethoxyphenyl)ethyl)-4-propoxy-
| 62897-64-7 |
|
Benzene,1-(2,2-dichloro-1-(4-ethoxyphenyl)propyl)-4-propoxy-
| 62897-69-2 |
|
Benzene, dichloroethyl-
| 1331-29-9 |
|
Benzene, 1,1'-(2,2-dichloroethylidene)bis(4-ethoxy-
| 7388-32-1 |
|
Benzene, 1,1'-(2-dichloroethylidene)bis(4-methoxy-
| 7388-31-0 |
|
Benzene, (dichloromethyl)-
| 98-87-3 |
|
Benzene, 1-(dichloromethyl)-3-phenoxy-
| 53874-68-3 |
|
Benzene, 1,2-dichloro-4-(4-(methylsulfonyl)phenoxy)-
| 83642-20-0 |
|
Benzenearsonic acid, 4-hydroxy-3-nitro-
| 121-19-7 |
|
Benzene, 1,2-dichloro-3-nitro-
| 3209-22-1 |
|
Benzene, 1,2-dichloro-4-nitro-
| 99-54-7 |
|
Benzene, 1,4-dichloro-2-nitro-
| 89-61-2 |
|
Benzene, 2,4-dichloro-1-nitro-
| 611-06-3 |
|
Benzene, 1,3-dichloro-2-(2-nitroethenyl)-
| 22482-43-5 |
|
Benzene, 2,4-dichloro-1-(4-nitrosophenoxy)-
| 73143-91-6 |
|
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylbutoxy)methyl)-3-phenoxy-
| 80844-04-8 |
|
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-(4-fluorophenoxy)-
| 80843-69-2 |
|
Benzene,4-((2-(3,5-dichlorophenyl)-2-methylpropoxy)methyl)-1-fluoro-2-phenoxy-
| 83493-32-7 |
|
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-(4-methoxyphenoxy)-
| 80843-93-2 |
|
Benzenearsonic acid, 4-(1-(2-hydroxy)propoxy)-
| 5411-08-5 |
|
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-phenoxy-
| 80844-00-4 |
|
|