*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CZ5250000
CHEMICAL NAME : Benzene, 1,2-dichloro-4-nitro-
CAS REGISTRY NUMBER : 99-54-7
BEILSTEIN REFERENCE NO. : 1818163
REFERENCE : 4-05-00-00726 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C6-H3-Cl2-N-O2
MOLECULAR WEIGHT : 192.00
WISWESSER LINE NOTATION : WNR CG DG
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* DCNB
* 3,4-Dichlornitrobenzen
* 1,2-Dichloro-4-nitrobenzene
* 3,4-Dichloronitrobenzene
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,601,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,601,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 953 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533734
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533734
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533585
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1384 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,47,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533585
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,47,1982
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533734
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536149
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - thrombocytopenia
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(11),26,1969
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 28 mg/m3/4H/21D-I
TOXIC EFFECTS :
Blood - eosinophilia
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(11),26,1969
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 250 ug/plate
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 29,34,1987
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 200 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9189
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
1,4-Benzenedicarboxylic acid, dioctyl ester
| 4654-26-6 |
1,2-Benzenedicarboxylic acid, di-2-propenyl ester
| 131-17-9 |
1,3-Benzenedicarboxylic acid, di-2-propenyl ester,homopolymer
| 25035-78-3 |
1,3-Benzenedicarboxylic acid, di-2-propenyl ester
| 1087-21-4 |
Benzenearsonic acid,p-((p-(hexadecylamino)phenyl)azo)-
| 1087-21-4 |
1,2-Benzenedicarboxylic acid, esters, dimethyl ester,mixt. with pentachlorophenol and 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxybenzene)
| 116189-57-2 |
1,3-Benzenedicarboxylic acid, 5-hydroxy-
| 618-83-7 |
1,3-Benzenedicarboxylic acid, 4-hydroxy-, 3-ethyl1-methyl ester
| 618-83-7 |
1,3-Benzenedicarboxylic acid, 4-hydroxy-,1-(1-methylethyl) 3-methyl ester
| 618-83-7 |
1,2-Benzenedicarboxylic acid, 3-methoxy-, dihydrazide
| 103724-37-4 |
1,2-Benzenedicarboxylic acid, monooctyl ester
| 5393-19-1 |
1,2-Benzenedicarboxylic acid, mono(phenylmethyl)ester
| 2528-16-7 |
1,2-Benzenedicarboxylic acid, monopotassium salt
| 877-24-7 |
1,3-Benzenedicarboxylic acid, 5-nitro-,bis(1-methylethyl) ester
| 10552-74-6 |
1,3-Benzenedicarboxylic acid, 5-nitro-, dimethylester
| 13290-96-5 |
Benzenearsonic acid, p-((p-(hexylamino)phenyl)azo)-
| 13290-96-5 |
1,4-Benzenedicarboxylic acid, polymer with1,4-benzenediamine
| 25035-37-4 |
Benzene-1,3-dicarboxylic acid, 5-sulfo-
| 22326-31-4 |
1,4-Benzenedicarboxylic acid, 2,3,5,6-tetrachloro-
| 2136-79-0 |
Benzene, m-dichloro-
| 541-73-1 |
Benzene, o-dichloro-
| 95-50-1 |
Benzene, p-dichloro-
| 106-46-7 |
Benzene, dichlorocyclohexyl-
| 59330-98-2 |
Benzene, 1,4-dichloro-2,5-dimethoxy-
| 2675-77-6 |
Benzene, 1,2-dichloro-4,5-dinitro-
| 6306-39-4 |
Benzene, 1,5-dichloro-2,3-dinitro-
| 28689-08-9 |
Benzenearsonic acid, p-hydroxy-
| 98-14-6 |
Benzene, dichlorodinitro-, and dichloronitrobenzene
| 98-14-6 |
Benzene, (((1,2-dichloroethenyl)thio)methyl)-
| 91085-62-0 |
Benzene,1-(2,2-dichloro-1-(4-ethoxyphenyl)ethyl)-4-propoxy-
| 62897-64-7 |
Benzene,1-(2,2-dichloro-1-(4-ethoxyphenyl)propyl)-4-propoxy-
| 62897-69-2 |
Benzene, dichloroethyl-
| 1331-29-9 |
Benzene, 1,1'-(2,2-dichloroethylidene)bis(4-ethoxy-
| 7388-32-1 |
Benzene, 1,1'-(2-dichloroethylidene)bis(4-methoxy-
| 7388-31-0 |
Benzene, (dichloromethyl)-
| 98-87-3 |
Benzene, 1-(dichloromethyl)-3-phenoxy-
| 53874-68-3 |
Benzene, 1,2-dichloro-4-(4-(methylsulfonyl)phenoxy)-
| 83642-20-0 |
Benzenearsonic acid, 4-hydroxy-3-nitro-
| 121-19-7 |
Benzene, 1,2-dichloro-3-nitro-
| 3209-22-1 |
Benzene, 1,2-dichloro-4-nitro-
| 99-54-7 |
Benzene, 1,4-dichloro-2-nitro-
| 89-61-2 |
Benzene, 2,4-dichloro-1-nitro-
| 611-06-3 |
Benzene, 1,3-dichloro-2-(2-nitroethenyl)-
| 22482-43-5 |
Benzene, 2,4-dichloro-1-(4-nitrosophenoxy)-
| 73143-91-6 |
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylbutoxy)methyl)-3-phenoxy-
| 80844-04-8 |
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-(4-fluorophenoxy)-
| 80843-69-2 |
Benzene,4-((2-(3,5-dichlorophenyl)-2-methylpropoxy)methyl)-1-fluoro-2-phenoxy-
| 83493-32-7 |
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-(4-methoxyphenoxy)-
| 80843-93-2 |
Benzenearsonic acid, 4-(1-(2-hydroxy)propoxy)-
| 5411-08-5 |
Benzene,1-((2-(3,4-dichlorophenyl)-2-methylpropoxy)methyl)-3-phenoxy-
| 80844-00-4 |
|
|