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MSDS  : Benzophenone, 2-hydroxy-4-methoxy-
CAS  : 131-57-7
SYNONYMS  : * Benzophenone-3 * Cyasorb UV 9 * 2-Hydroxy-4-methoxybenzophenone * (2-Hydroxy-4-methoxyphenyl)phenylmethanone * Methanone, (2-hydroxy-4-methoxyphenyl)phenyl- * 4-Methoxy-2-hydroxybenzophenone * MOB * NCI-C60957 * NSC-7778 * Oxybenzone * Spectra-sorb UV 9 * Syntase 62 * UF 3 * USAF CY-9 * Uvinul M 40
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DJ1575000
CHEMICAL NAME : Benzophenone, 2-hydroxy-4-methoxy-
CAS REGISTRY NUMBER : 131-57-7
BEILSTEIN REFERENCE NO. : 1913145
REFERENCE : 4-08-00-02442 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C14-H12-O3
MOLECULAR WEIGHT : 228.26
WISWESSER LINE NOTATION : 1OR CQ DVR
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzophenone-3
* Cyasorb UV 9
* 2-Hydroxy-4-methoxybenzophenone
* (2-Hydroxy-4-methoxyphenyl)phenylmethanone
* Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-
* 4-Methoxy-2-hydroxybenzophenone
* MOB
* NCI-C60957
* NSC-7778
* Oxybenzone
* Spectra-sorb UV 9
* Syntase 62
* UF 3
* USAF CY-9
* Uvinul M 40

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 2(5),35,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 189 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in other cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8246 mg/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 164 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in platelet count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in other cell count (unspecified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 104 gm/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 544 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 45 gm/kg
SEX/DURATION : female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 54 gm/kg
SEX/DURATION : male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 333 gm/kg
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 297 gm/kg
SEX/DURATION : female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1268 gm/kg
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1687 gm/kg
SEX/DURATION : female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE : 5915 mg/kg
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3220
No. of Facilities: 51 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 549 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3220
No. of Facilities: 1336 (estimated)
No. of Industries: 21
No. of Occupations: 18
No. of Employees: 27518 (estimated)
No. of Female Employees: 8664 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

NTP Toxicity studies, RPT# TOX-21, October 1997

NTP Carcinogenesis studies; laboratory assigned, October 1997


*** END OF RECORD ***
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NAMECAS
Benzophenone, 4-ethyl-, oxime 2549-90-8
Benzoic acid, 4-(3-phenylsalicyloyl)amino-, sodiumsalt 64050-42-6
Benzophenone guanylhydrazone,4-fluoro-4'-trifluoromethyl-, hydrochloride 19982-87-7
Benzophenone, 2-hydroxy-4-butoxy- 15131-43-8
Benzophenone, 2-hydroxy-4-isopropoxy- 93434-38-9
Benzophenone, 2-hydroxy-4-methoxy- 131-57-7
Benzophenone, 2'-hydroxy-5'-methoxy- 14770-96-8
Benzophenone, 2-hydroxy-4'-methyl- 19434-30-1
Benzophenone, 2-hydroxy-4-(octyloxy)- 1843-05-6
Benzophenone, 2-hydroxy-4-(pentyloxy)- 83937-21-7
Benzophenone,4-(2-hydroxy-3-(4-phenylpiperazinyl)propoxy)-,dihydrochloride 64050-24-4
Benzophenone,4-((m-isopentyloxybenzylidene)amino)-3-methyl- 70318-56-8
Benzoic acid, o-(phenylsulfinyl)- 32664-47-4
Benzophenone,4-((p-isopentyloxybenzylidene)amino)-3-methyl- 70318-55-7
Benzophenone, 3-methoxy-4'-methyl- 82520-37-4
Benzophenone, 4-methoxy-4'-methyl- 23886-71-7
Benzophenone, 4-methoxy-3-morpholinomethyl-,hydrochloride 58324-25-7
Benzophenone, 4-methoxy-3-piperidinomethyl-,hydrochloride 58324-24-6
Benzophenone, 4-methoxy-3-(1-pyrrolidinylmethyl)-,hydrochloride 58324-23-5
Benzophenone, 4-methyl- 134-84-9
Benzophenone,2-(2-((alpha-methylphenethyl)amino)ethoxy)-,hydrochloride 10429-64-8
Benzophenone, 2-methyl-4'-phenyl- 85296-08-8
Benzophenone, 4-methyl-4'-phenyl- 39148-55-5
Benzoic acid, o-(phenylsulfonyl)- 58844-73-8
Benzophenone, 3-nitro-4,4',5-trimethyl- 98257-41-1
Benzophenone, oxime 574-66-3
Benzophenone, 4-phenethyl- 91036-10-1
Benzophenone, phenylhydrazone 574-61-8
Benzophenone, 2-(2-piperidinopropoxy)-, hydrobromide 10571-21-8
Benzophenone, 2,2',4,4'-tetrahydroxy- 131-55-5
Benzophenone, thio-, bis(2-(diethylamino)ethyl)acetal 131-55-5
Benzophenone, 2,2',5-trimethoxy- 32938-33-3
Benzophenone, 3,4,4'-trimethyl- 24964-78-1
12H-Benzo(b)phenoselenazine 64050-25-5
Benzoic acid, 2-((phenylsulfonyl)amino)- 34837-67-7
12H-Benzo(b)phenoselenazine, 12-methyl-, hydriodide 34837-67-7
5H-Benzo(a)phenoxazine,9-(dimethylamino)-5-imino-10-methyl-,monohydrochloride 18472-89-4
Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-,chloride 2381-85-3
Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-,perchlorate 53340-16-2
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Benzo(a)phenoxazin-7-ium,5-amino-9-(dimethylamino)-10-methyl-, perchlorate 52659-20-8
Benzo(pqr)picene 189-96-8
2H-1-Benzopyran 254-04-6
2H-1-Benzopyran-6-acetic acid,3,4-dihydro-7-chloro-4-oxo- 72765-99-2
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Benzoic acid,4-((1-oxo-3-(4-(2-pyridinyl)-1-piperazinyl)propyl)amino)-, ethyl ester, dihydrochloride 104393-11-5
Benzoic acid, o-(phenylthio)- 1527-12-4
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