*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DJ1575000
CHEMICAL NAME : Benzophenone, 2-hydroxy-4-methoxy-
CAS REGISTRY NUMBER : 131-57-7
BEILSTEIN REFERENCE NO. : 1913145
REFERENCE : 4-08-00-02442 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C14-H12-O3
MOLECULAR WEIGHT : 228.26
WISWESSER LINE NOTATION : 1OR CQ DVR
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzophenone-3
* Cyasorb UV 9
* 2-Hydroxy-4-methoxybenzophenone
* (2-Hydroxy-4-methoxyphenyl)phenylmethanone
* Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-
* 4-Methoxy-2-hydroxybenzophenone
* MOB
* NCI-C60957
* NSC-7778
* Oxybenzone
* Spectra-sorb UV 9
* Syntase 62
* UF 3
* USAF CY-9
* Uvinul M 40
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 2(5),35,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 189 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in other cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8246 mg/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 164 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in platelet count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in other cell count (unspecified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 104 gm/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 544 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg/2W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 45 gm/kg
SEX/DURATION : female 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 54 gm/kg
SEX/DURATION : male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 10,41,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 333 gm/kg
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 297 gm/kg
SEX/DURATION : female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1268 gm/kg
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1687 gm/kg
SEX/DURATION : female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE : 5915 mg/kg
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3344
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3220
No. of Facilities: 51 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 549 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3220
No. of Facilities: 1336 (estimated)
No. of Industries: 21
No. of Occupations: 18
No. of Employees: 27518 (estimated)
No. of Female Employees: 8664 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Toxicity studies, RPT# TOX-21, October 1997
NTP Carcinogenesis studies; laboratory assigned, October 1997
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Benzophenone, 4-ethyl-, oxime
| 2549-90-8 |
Benzoic acid, 4-(3-phenylsalicyloyl)amino-, sodiumsalt
| 64050-42-6 |
Benzophenone guanylhydrazone,4-fluoro-4'-trifluoromethyl-, hydrochloride
| 19982-87-7 |
Benzophenone, 2-hydroxy-4-butoxy-
| 15131-43-8 |
Benzophenone, 2-hydroxy-4-isopropoxy-
| 93434-38-9 |
Benzophenone, 2-hydroxy-4-methoxy-
| 131-57-7 |
Benzophenone, 2'-hydroxy-5'-methoxy-
| 14770-96-8 |
Benzophenone, 2-hydroxy-4'-methyl-
| 19434-30-1 |
Benzophenone, 2-hydroxy-4-(octyloxy)-
| 1843-05-6 |
Benzophenone, 2-hydroxy-4-(pentyloxy)-
| 83937-21-7 |
Benzophenone,4-(2-hydroxy-3-(4-phenylpiperazinyl)propoxy)-,dihydrochloride
| 64050-24-4 |
Benzophenone,4-((m-isopentyloxybenzylidene)amino)-3-methyl-
| 70318-56-8 |
Benzoic acid, o-(phenylsulfinyl)-
| 32664-47-4 |
Benzophenone,4-((p-isopentyloxybenzylidene)amino)-3-methyl-
| 70318-55-7 |
Benzophenone, 3-methoxy-4'-methyl-
| 82520-37-4 |
Benzophenone, 4-methoxy-4'-methyl-
| 23886-71-7 |
Benzophenone, 4-methoxy-3-morpholinomethyl-,hydrochloride
| 58324-25-7 |
Benzophenone, 4-methoxy-3-piperidinomethyl-,hydrochloride
| 58324-24-6 |
Benzophenone, 4-methoxy-3-(1-pyrrolidinylmethyl)-,hydrochloride
| 58324-23-5 |
Benzophenone, 4-methyl-
| 134-84-9 |
Benzophenone,2-(2-((alpha-methylphenethyl)amino)ethoxy)-,hydrochloride
| 10429-64-8 |
Benzophenone, 2-methyl-4'-phenyl-
| 85296-08-8 |
Benzophenone, 4-methyl-4'-phenyl-
| 39148-55-5 |
Benzoic acid, o-(phenylsulfonyl)-
| 58844-73-8 |
Benzophenone, 3-nitro-4,4',5-trimethyl-
| 98257-41-1 |
Benzophenone, oxime
| 574-66-3 |
Benzophenone, 4-phenethyl-
| 91036-10-1 |
Benzophenone, phenylhydrazone
| 574-61-8 |
Benzophenone, 2-(2-piperidinopropoxy)-, hydrobromide
| 10571-21-8 |
Benzophenone, 2,2',4,4'-tetrahydroxy-
| 131-55-5 |
Benzophenone, thio-, bis(2-(diethylamino)ethyl)acetal
| 131-55-5 |
Benzophenone, 2,2',5-trimethoxy-
| 32938-33-3 |
Benzophenone, 3,4,4'-trimethyl-
| 24964-78-1 |
12H-Benzo(b)phenoselenazine
| 64050-25-5 |
Benzoic acid, 2-((phenylsulfonyl)amino)-
| 34837-67-7 |
12H-Benzo(b)phenoselenazine, 12-methyl-, hydriodide
| 34837-67-7 |
5H-Benzo(a)phenoxazine,9-(dimethylamino)-5-imino-10-methyl-,monohydrochloride
| 18472-89-4 |
Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-,chloride
| 2381-85-3 |
Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-,perchlorate
| 53340-16-2 |
Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-,sulfate (2:1)
| 3625-57-8 |
Benzo(a)phenoxazin-7-ium,5-amino-9-(dimethylamino)-10-methyl-, perchlorate
| 52659-20-8 |
Benzo(pqr)picene
| 189-96-8 |
2H-1-Benzopyran
| 254-04-6 |
2H-1-Benzopyran-6-acetic acid,3,4-dihydro-7-chloro-4-oxo-
| 72765-99-2 |
2H-1-Benzopyran-6-acetic acid,3,4-dihydro-8-chloro-4-oxo-
| 72765-98-1 |
Benzoic acid,4-((1-oxo-3-(4-(2-pyridinyl)-1-piperazinyl)propyl)amino)-, ethyl ester, dihydrochloride
| 104393-11-5 |
Benzoic acid, o-(phenylthio)-
| 1527-12-4 |
2H-1-Benzopyran-6-acetic acid,3,4-dihydro-alpha-ethyl-4-oxo-
| 72766-00-8 |
2H-1-Benzopyran-6-acetic acid,3,4-dihydro-8-hydroxy-4-oxo-
| 72766-01-9 |
2H-1-Benzopyran-6-acetic acid,3,4-dihydro-alpha-methyl-4-oxo-
| 58282-64-7 |
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