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MSDS  
:
 Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt
CAS  
:
 3653-48-3
SYNONYMS  
:
 * Acetic acid, (4-chloro-2-methylphenoxy)-, sodium salt
* Agroxone 3
* 4-Chloro-2-methylphenoxyacetic acid sodium salt
* (p-Chloro-o-tolyloxy)acetic acid sodium salt
* Chwastoks
* Chwastox
* Chwastox 80
* Diamet
* Dicotex 80
* Dikoteks
* Dikotex 30
* Estermine
* Hedonal M80
* MCPA sodium salt
* Metaxone
* Methoxon
* Methoxone
* (2-Methyl-4-chlorophenoxy)acetic acid, sodium salt
* 2M-4KH sodium salt
* Phenoxylene
* Sodium (4-chloro-2-methylphenoxy)acetate
* Sodium MCPA
* Sodium (2-methyl-4-chlorophenoxy)acetate
* SYS 67ME
* U 46M

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AG2625000
CHEMICAL NAME           : Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt
CAS REGISTRY NUMBER     : 3653-48-3
OTHER CAS REGISTRY NOS. : 11114-06-0
LAST UPDATED            : 199701
DATA ITEMS CITED        : 22
MOLECULAR FORMULA       : C9-H8-Cl-O3.Na
MOLECULAR WEIGHT        : 222.61
WISWESSER LINE NOTATION : OV1OR DG B1 &-NA-
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Acetic acid, (4-chloro-2-methylphenoxy)-, sodium salt
   * Agroxone 3
   * 4-Chloro-2-methylphenoxyacetic acid sodium salt
   * (p-Chloro-o-tolyloxy)acetic acid sodium salt
   * Chwastoks
   * Chwastox
   * Chwastox 80
   * Diamet
   * Dicotex 80
   * Dikoteks
   * Dikotex 30
   * Estermine
   * Hedonal M80
   * MCPA sodium salt
   * Metaxone
   * Methoxon
   * Methoxone
   * (2-Methyl-4-chlorophenoxy)acetic acid, sodium salt
   * 2M-4KH sodium salt
   * Phenoxylene
   * Sodium (4-chloro-2-methylphenoxy)acetate
   * Sodium MCPA
   * Sodium (2-methyl-4-chlorophenoxy)acetate
   * SYS 67ME
   * U 46M
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 520 mg/m3/4H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 3,883,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 18,152,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34(2),109,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 3,883,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 870 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(8),86,1982
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >256 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 3,349,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14400 mg/kg/90D-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Blood - pigmented or nucleated red blood cells
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 3,349,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7056 mg/kg/9W-C
TOXIC EFFECTS :
   Brain and Coverings - changes in brain weight
   Liver - changes in liver weight
   Endocrine - changes in adrenal weight
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 18,152,1977
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg/4H/17W-I
TOXIC EFFECTS :
   Liver - other changes
   Endocrine - changes in spleen weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1600 mg/kg/8D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Related to Chronic Data - death
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15 gm/kg/3W-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 3,349,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11400 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 48,243,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 542 mg/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(2),31,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3900 mg/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34(2),109,1969
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Bird - chicken
DOSE/DURATION           : 2800 ug/egg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,327,1992

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acetic acid, (benzylthio)-, 2,3-dimercaptopropylester 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-,alpha-((dimethylamino)methyl)benzyl ester,hydrochloride 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-, ethyl ester 2698-38-6
Acetic acid, ((4-chloro-o-tolyl)oxy)-, compd. with2,2'-iminodiethanol (1:1) 20405-19-0
Acetic acid, ((4-chloro-o-tolyl)oxy)-, isooctyl ester 26544-20-7
Acetic acid, ((4-chloro-o-tolyl)oxy)-, methyl ester(8CI) 2436-73-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, potassium salt 5221-16-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt 3653-48-3
Acetic acid, ((4-chloro-o-tolyl)oxy)thio-, S-ethylester 25319-90-8
Acetic acid, ((4-chloro-o-tolyl)sulfonyl)-, compd.with 2,2',2''-nitrilotrisethanol (1:1) 102582-95-6
Acetic acid, chloro-,2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester 74940-61-7
Acetic acid, (o-(benzylthio)phenyl)-,2-(dimethylamino)ethyl ester, hydrochloride 14200-07-8
Acetic acid, chloro-, 2,4,5-trichlorophenyl ester 5902-69-2
Acetic acid,(4-chloro-2-(alpha,alpha,alpha-trifluoro-m-toluamido)phenyl)- 17194-48-8
Acetic acid,(4-chloro-2-((alpha,alpha,alpha-trifluoro-m-tolyl)carbamoyl)phenoxy)- 35422-42-5
Acetic acid,((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)- 50892-23-4
Acetic acid, chromium(3+) salt 1066-30-4
Acetic acid, chromium(2+) salt, hydrate 628-52-4
Acetic acid, chromium(3+) salt, hydrate 25013-82-5
Acetic acid, cobalt(2+) salt 71-48-7
Acetic acid, cobalt(3+) salt 917-69-1
Acetic acid, cobalt(2+) salt, tetrahydrate 6147-53-1
Acetic acid, beryllium salt 543-81-7
Acetic acid, copper(2+) salt 142-71-2
Acetic acid, copper(2+) salt, monohydrate 6046-93-1
Acetic acid, cyano- 372-09-8
Acetic acid, cyano-, allyl ester 13361-32-5
Acetic acid, cyano-, benzylidenehydrazide 4974-44-1
Acetic acid, cyano-, butyl ester 5459-58-5
Acetic acid,cyano(1-(cyanomethyl)-2-pyrrolidinylidene)-, ethylester 106345-05-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-oxoethyl)-2-pyrrolidinylide ne)-, ethyl ester 126647-18-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-thioxoethyl)-2- pyrrolidinylidene)-, ethyl ester 111038-14-3
Acetic acid,alpha-cyano-alpha-(3,5-dimethyl-4-oxacyclohexylidene)-, ethyl ester 10292-81-6
Acetic acid, (4,4'-biphenylylenedithio)di-, compd.with 2,2',2''-nitrilotris(ethanol) (1:2) 87298-97-3
Acetic acid, (2-cyanoethoxy)diphenyl-,2-(dimethylamino)ethyl ester 94916-96-8
Acetic acid, cyano(ethoxyethylidene)-, ethyl ester 64046-50-0
Acetic acid, cyano-, ethyl ester 105-56-6
Acetic acid, cyano-, hexyl ester 13361-53-0
Acetic acid, cyano-, hydrazide 140-87-4
Acetic acid, cyano-, (o-hydroxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-,(4-hydroxy-3-methoxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-, isobutyl ester 13361-31-4
Acetic acid, cyano-, isopropyl ester 13361-30-3
Acetic acid, cyano-, 2-methoxyethyl ester 10258-54-5
Acetic acid, 2-(4-biphenylyl)-2-methyl-,2-piperidinoethyl ester 64046-66-8
Acetic acid,((2-cyano-3-(methylamino)phenyl)amino)oxo-,monosodium salt 63365-44-6
Acetic acid, cyano-, methyl ester 105-34-0
Acetic acid, cyano((3-methylphenyl)hydrazono)-, ethylester 3994-20-5
Acetic acid, cyano((4-methylphenyl)hydrazono)-, ethylester 6797-29-1
Acetic acid, cyano((3-methylphenyl)hydrazono)-,methyl ester 59061-89-1

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