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MSDS  : Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt
CAS  : 3653-48-3
SYNONYMS  : * Acetic acid, (4-chloro-2-methylphenoxy)-, sodium salt * Agroxone 3 * 4-Chloro-2-methylphenoxyacetic acid sodium salt * (p-Chloro-o-tolyloxy)acetic acid sodium salt * Chwastoks * Chwastox * Chwastox 80 * Diamet * Dicotex 80 * Dikoteks * Dikotex 30 * Estermine * Hedonal M80 * MCPA sodium salt * Metaxone * Methoxon * Methoxone * (2-Methyl-4-chlorophenoxy)acetic acid, sodium salt * 2M-4KH sodium salt * Phenoxylene * Sodium (4-chloro-2-methylphenoxy)acetate * Sodium MCPA * Sodium (2-methyl-4-chlorophenoxy)acetate * SYS 67ME * U 46M
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AG2625000
CHEMICAL NAME : Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt
CAS REGISTRY NUMBER : 3653-48-3
OTHER CAS REGISTRY NOS. : 11114-06-0
LAST UPDATED : 199701
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C9-H8-Cl-O3.Na
MOLECULAR WEIGHT : 222.61
WISWESSER LINE NOTATION : OV1OR DG B1 &-NA-
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acetic acid, (4-chloro-2-methylphenoxy)-, sodium salt
* Agroxone 3
* 4-Chloro-2-methylphenoxyacetic acid sodium salt
* (p-Chloro-o-tolyloxy)acetic acid sodium salt
* Chwastoks
* Chwastox
* Chwastox 80
* Diamet
* Dicotex 80
* Dikoteks
* Dikotex 30
* Estermine
* Hedonal M80
* MCPA sodium salt
* Metaxone
* Methoxon
* Methoxone
* (2-Methyl-4-chlorophenoxy)acetic acid, sodium salt
* 2M-4KH sodium salt
* Phenoxylene
* Sodium (4-chloro-2-methylphenoxy)acetate
* Sodium MCPA
* Sodium (2-methyl-4-chlorophenoxy)acetate
* SYS 67ME
* U 46M

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 520 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 3,883,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Gastrointestinal - hypermotility, diarrhea
Blood - hemorrhage
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 18,152,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(2),109,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 3,883,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 870 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 47(8),86,1982

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >256 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 3,349,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14400 mg/kg/90D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 3,349,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7056 mg/kg/9W-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Endocrine - changes in adrenal weight
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 18,152,1977

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 mg/kg/4H/17W-I
TOXIC EFFECTS :
Liver - other changes
Endocrine - changes in spleen weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1600 mg/kg/8D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - dermatitis, other (after systemic exposure)
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15 gm/kg/3W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 3,349,1975

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 11400 mg/kg
SEX/DURATION : male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 48,243,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 542 mg/kg
SEX/DURATION : female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(2),31,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 3900 mg/kg
SEX/DURATION : multigeneration
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(2),109,1969

** MUTATION DATA **

TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 2800 ug/egg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
19,327,1992

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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NAMECAS
Acetic acid, (benzylthio)-, 2,3-dimercaptopropylester 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-,alpha-((dimethylamino)methyl)benzyl ester,hydrochloride 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-, ethyl ester 2698-38-6
Acetic acid, ((4-chloro-o-tolyl)oxy)-, compd. with2,2'-iminodiethanol (1:1) 20405-19-0
Acetic acid, ((4-chloro-o-tolyl)oxy)-, isooctyl ester 26544-20-7
Acetic acid, ((4-chloro-o-tolyl)oxy)-, methyl ester(8CI) 2436-73-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, potassium salt 5221-16-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt 3653-48-3
Acetic acid, ((4-chloro-o-tolyl)oxy)thio-, S-ethylester 25319-90-8
Acetic acid, ((4-chloro-o-tolyl)sulfonyl)-, compd.with 2,2',2''-nitrilotrisethanol (1:1) 102582-95-6
Acetic acid, chloro-,2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester 74940-61-7
Acetic acid, (o-(benzylthio)phenyl)-,2-(dimethylamino)ethyl ester, hydrochloride 14200-07-8
Acetic acid, chloro-, 2,4,5-trichlorophenyl ester 5902-69-2
Acetic acid,(4-chloro-2-(alpha,alpha,alpha-trifluoro-m-toluamido)phenyl)- 17194-48-8
Acetic acid,(4-chloro-2-((alpha,alpha,alpha-trifluoro-m-tolyl)carbamoyl)phenoxy)- 35422-42-5
Acetic acid,((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)- 50892-23-4
Acetic acid, chromium(3+) salt 1066-30-4
Acetic acid, chromium(2+) salt, hydrate 628-52-4
Acetic acid, chromium(3+) salt, hydrate 25013-82-5
Acetic acid, cobalt(2+) salt 71-48-7
Acetic acid, cobalt(3+) salt 917-69-1
Acetic acid, cobalt(2+) salt, tetrahydrate 6147-53-1
Acetic acid, beryllium salt 543-81-7
Acetic acid, copper(2+) salt 142-71-2
Acetic acid, copper(2+) salt, monohydrate 6046-93-1
Acetic acid, cyano- 372-09-8
Acetic acid, cyano-, allyl ester 13361-32-5
Acetic acid, cyano-, benzylidenehydrazide 4974-44-1
Acetic acid, cyano-, butyl ester 5459-58-5
Acetic acid,cyano(1-(cyanomethyl)-2-pyrrolidinylidene)-, ethylester 106345-05-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-oxoethyl)-2-pyrrolidinylide ne)-, ethyl ester 126647-18-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-thioxoethyl)-2- pyrrolidinylidene)-, ethyl ester 111038-14-3
Acetic acid,alpha-cyano-alpha-(3,5-dimethyl-4-oxacyclohexylidene)-, ethyl ester 10292-81-6
Acetic acid, (4,4'-biphenylylenedithio)di-, compd.with 2,2',2''-nitrilotris(ethanol) (1:2) 87298-97-3
Acetic acid, (2-cyanoethoxy)diphenyl-,2-(dimethylamino)ethyl ester 94916-96-8
Acetic acid, cyano(ethoxyethylidene)-, ethyl ester 64046-50-0
Acetic acid, cyano-, ethyl ester 105-56-6
Acetic acid, cyano-, hexyl ester 13361-53-0
Acetic acid, cyano-, hydrazide 140-87-4
Acetic acid, cyano-, (o-hydroxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-,(4-hydroxy-3-methoxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-, isobutyl ester 13361-31-4
Acetic acid, cyano-, isopropyl ester 13361-30-3
Acetic acid, cyano-, 2-methoxyethyl ester 10258-54-5
Acetic acid, 2-(4-biphenylyl)-2-methyl-,2-piperidinoethyl ester 64046-66-8
Acetic acid,((2-cyano-3-(methylamino)phenyl)amino)oxo-,monosodium salt 63365-44-6
Acetic acid, cyano-, methyl ester 105-34-0
Acetic acid, cyano((3-methylphenyl)hydrazono)-, ethylester 3994-20-5
Acetic acid, cyano((4-methylphenyl)hydrazono)-, ethylester 6797-29-1
Acetic acid, cyano((3-methylphenyl)hydrazono)-,methyl ester 59061-89-1

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