*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AG3150000
CHEMICAL NAME : Acetic acid, cobalt(2+) salt
CAS REGISTRY NUMBER : 71-48-7
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C4-H6-O4.Co
MOLECULAR WEIGHT : 177.03
WISWESSER LINE NOTATION : OV1 2 &-CO-
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Bis(acetato)cobalt
* Cobalt acetate
* Cobalt(2+) acetate
* Cobalt acetate (Co(OAc)2)
* Cobalt(II) acetate
* Cobalt diacetate
* Cobaltous acetate
* Cobaltous diacetate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 503 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
20,311,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 31 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 23,455,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 23,455,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/m3/24H/17W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 57(11-12),22,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 135 mg/kg/9D-I
TOXIC EFFECTS :
Cardiac - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Neurotransmitters or modulators (putative) - catecholamine
levels in sympathetic nerves
REFERENCE :
KARDA2 Kardiologiia. (Izdatel'stvo Meditsina, Petroverigskii pereulok 6/8
101000 Moscow, Russia) V.1- 1989- Volume(issue)/page/year: 18,54,1978
** MUTATION DATA **
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 200 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,193,1979
*** REVIEWS ***
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,363,1991
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,363,1991
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81777
No. of Facilities: 603 (estimated)
No. of Industries: 8
No. of Occupations: 20
No. of Employees: 5023 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81777
No. of Facilities: 622 (estimated)
No. of Industries: 13
No. of Occupations: 16
No. of Employees: 15156 (estimated)
No. of Female Employees: 4580 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Acetic acid, (benzylthio)-, 2,3-dimercaptopropylester
| 90730-51-1 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-,alpha-((dimethylamino)methyl)benzyl ester,hydrochloride
| 90730-51-1 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-, ethyl ester
| 2698-38-6 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-, compd. with2,2'-iminodiethanol (1:1)
| 20405-19-0 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-, isooctyl ester
| 26544-20-7 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-, methyl ester(8CI)
| 2436-73-9 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-, potassium salt
| 5221-16-9 |
Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt
| 3653-48-3 |
Acetic acid, ((4-chloro-o-tolyl)oxy)thio-, S-ethylester
| 25319-90-8 |
Acetic acid, ((4-chloro-o-tolyl)sulfonyl)-, compd.with 2,2',2''-nitrilotrisethanol (1:1)
| 102582-95-6 |
Acetic acid, chloro-,2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester
| 74940-61-7 |
Acetic acid, (o-(benzylthio)phenyl)-,2-(dimethylamino)ethyl ester, hydrochloride
| 14200-07-8 |
Acetic acid, chloro-, 2,4,5-trichlorophenyl ester
| 5902-69-2 |
Acetic acid,(4-chloro-2-(alpha,alpha,alpha-trifluoro-m-toluamido)phenyl)-
| 17194-48-8 |
Acetic acid,(4-chloro-2-((alpha,alpha,alpha-trifluoro-m-tolyl)carbamoyl)phenoxy)-
| 35422-42-5 |
Acetic acid,((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-
| 50892-23-4 |
Acetic acid, chromium(3+) salt
| 1066-30-4 |
Acetic acid, chromium(2+) salt, hydrate
| 628-52-4 |
Acetic acid, chromium(3+) salt, hydrate
| 25013-82-5 |
Acetic acid, cobalt(2+) salt
| 71-48-7 |
Acetic acid, cobalt(3+) salt
| 917-69-1 |
Acetic acid, cobalt(2+) salt, tetrahydrate
| 6147-53-1 |
Acetic acid, beryllium salt
| 543-81-7 |
Acetic acid, copper(2+) salt
| 142-71-2 |
Acetic acid, copper(2+) salt, monohydrate
| 6046-93-1 |
Acetic acid, cyano-
| 372-09-8 |
Acetic acid, cyano-, allyl ester
| 13361-32-5 |
Acetic acid, cyano-, benzylidenehydrazide
| 4974-44-1 |
Acetic acid, cyano-, butyl ester
| 5459-58-5 |
Acetic acid,cyano(1-(cyanomethyl)-2-pyrrolidinylidene)-, ethylester
| 106345-05-5 |
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-oxoethyl)-2-pyrrolidinylide ne)-, ethyl ester
| 126647-18-5 |
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-thioxoethyl)-2- pyrrolidinylidene)-, ethyl ester
| 111038-14-3 |
Acetic acid,alpha-cyano-alpha-(3,5-dimethyl-4-oxacyclohexylidene)-, ethyl ester
| 10292-81-6 |
Acetic acid, (4,4'-biphenylylenedithio)di-, compd.with 2,2',2''-nitrilotris(ethanol) (1:2)
| 87298-97-3 |
Acetic acid, (2-cyanoethoxy)diphenyl-,2-(dimethylamino)ethyl ester
| 94916-96-8 |
Acetic acid, cyano(ethoxyethylidene)-, ethyl ester
| 64046-50-0 |
Acetic acid, cyano-, ethyl ester
| 105-56-6 |
Acetic acid, cyano-, hexyl ester
| 13361-53-0 |
Acetic acid, cyano-, hydrazide
| 140-87-4 |
Acetic acid, cyano-, (o-hydroxybenzylidene)hydrazide
| 140-87-4 |
Acetic acid, cyano-,(4-hydroxy-3-methoxybenzylidene)hydrazide
| 140-87-4 |
Acetic acid, cyano-, isobutyl ester
| 13361-31-4 |
Acetic acid, cyano-, isopropyl ester
| 13361-30-3 |
Acetic acid, cyano-, 2-methoxyethyl ester
| 10258-54-5 |
Acetic acid, 2-(4-biphenylyl)-2-methyl-,2-piperidinoethyl ester
| 64046-66-8 |
Acetic acid,((2-cyano-3-(methylamino)phenyl)amino)oxo-,monosodium salt
| 63365-44-6 |
Acetic acid, cyano-, methyl ester
| 105-34-0 |
Acetic acid, cyano((3-methylphenyl)hydrazono)-, ethylester
| 3994-20-5 |
Acetic acid, cyano((4-methylphenyl)hydrazono)-, ethylester
| 6797-29-1 |
Acetic acid, cyano((3-methylphenyl)hydrazono)-,methyl ester
| 59061-89-1 |
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