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MSDS  : Acetic acid, cobalt(2+) salt
CAS  : 71-48-7
SYNONYMS  : * Bis(acetato)cobalt * Cobalt acetate * Cobalt(2+) acetate * Cobalt acetate (Co(OAc)2) * Cobalt(II) acetate * Cobalt diacetate * Cobaltous acetate * Cobaltous diacetate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AG3150000
CHEMICAL NAME : Acetic acid, cobalt(2+) salt
CAS REGISTRY NUMBER : 71-48-7
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C4-H6-O4.Co
MOLECULAR WEIGHT : 177.03
WISWESSER LINE NOTATION : OV1 2 &-CO-
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Bis(acetato)cobalt
* Cobalt acetate
* Cobalt(2+) acetate
* Cobalt acetate (Co(OAc)2)
* Cobalt(II) acetate
* Cobalt diacetate
* Cobaltous acetate
* Cobaltous diacetate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 503 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
20,311,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 31 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 23,455,1964

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 23,455,1964

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/m3/24H/17W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 57(11-12),22,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 135 mg/kg/9D-I
TOXIC EFFECTS :
Cardiac - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Neurotransmitters or modulators (putative) - catecholamine
levels in sympathetic nerves
REFERENCE :
KARDA2 Kardiologiia. (Izdatel'stvo Meditsina, Petroverigskii pereulok 6/8
101000 Moscow, Russia) V.1- 1989- Volume(issue)/page/year: 18,54,1978

** MUTATION DATA **

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 200 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,193,1979

*** REVIEWS ***

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,363,1991

IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,363,1991

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81777
No. of Facilities: 603 (estimated)
No. of Industries: 8
No. of Occupations: 20
No. of Employees: 5023 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81777
No. of Facilities: 622 (estimated)
No. of Industries: 13
No. of Occupations: 16
No. of Employees: 15156 (estimated)
No. of Female Employees: 4580 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acetic acid, (benzylthio)-, 2,3-dimercaptopropylester 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-,alpha-((dimethylamino)methyl)benzyl ester,hydrochloride 90730-51-1
Acetic acid, ((4-chloro-o-tolyl)oxy)-, ethyl ester 2698-38-6
Acetic acid, ((4-chloro-o-tolyl)oxy)-, compd. with2,2'-iminodiethanol (1:1) 20405-19-0
Acetic acid, ((4-chloro-o-tolyl)oxy)-, isooctyl ester 26544-20-7
Acetic acid, ((4-chloro-o-tolyl)oxy)-, methyl ester(8CI) 2436-73-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, potassium salt 5221-16-9
Acetic acid, ((4-chloro-o-tolyl)oxy)-, sodium salt 3653-48-3
Acetic acid, ((4-chloro-o-tolyl)oxy)thio-, S-ethylester 25319-90-8
Acetic acid, ((4-chloro-o-tolyl)sulfonyl)-, compd.with 2,2',2''-nitrilotrisethanol (1:1) 102582-95-6
Acetic acid, chloro-,2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester 74940-61-7
Acetic acid, (o-(benzylthio)phenyl)-,2-(dimethylamino)ethyl ester, hydrochloride 14200-07-8
Acetic acid, chloro-, 2,4,5-trichlorophenyl ester 5902-69-2
Acetic acid,(4-chloro-2-(alpha,alpha,alpha-trifluoro-m-toluamido)phenyl)- 17194-48-8
Acetic acid,(4-chloro-2-((alpha,alpha,alpha-trifluoro-m-tolyl)carbamoyl)phenoxy)- 35422-42-5
Acetic acid,((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)- 50892-23-4
Acetic acid, chromium(3+) salt 1066-30-4
Acetic acid, chromium(2+) salt, hydrate 628-52-4
Acetic acid, chromium(3+) salt, hydrate 25013-82-5
Acetic acid, cobalt(2+) salt 71-48-7
Acetic acid, cobalt(3+) salt 917-69-1
Acetic acid, cobalt(2+) salt, tetrahydrate 6147-53-1
Acetic acid, beryllium salt 543-81-7
Acetic acid, copper(2+) salt 142-71-2
Acetic acid, copper(2+) salt, monohydrate 6046-93-1
Acetic acid, cyano- 372-09-8
Acetic acid, cyano-, allyl ester 13361-32-5
Acetic acid, cyano-, benzylidenehydrazide 4974-44-1
Acetic acid, cyano-, butyl ester 5459-58-5
Acetic acid,cyano(1-(cyanomethyl)-2-pyrrolidinylidene)-, ethylester 106345-05-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-oxoethyl)-2-pyrrolidinylide ne)-, ethyl ester 126647-18-5
Acetic acid,cyano(1-(2-(((dimethylamino)methylene)amino)-2-thioxoethyl)-2- pyrrolidinylidene)-, ethyl ester 111038-14-3
Acetic acid,alpha-cyano-alpha-(3,5-dimethyl-4-oxacyclohexylidene)-, ethyl ester 10292-81-6
Acetic acid, (4,4'-biphenylylenedithio)di-, compd.with 2,2',2''-nitrilotris(ethanol) (1:2) 87298-97-3
Acetic acid, (2-cyanoethoxy)diphenyl-,2-(dimethylamino)ethyl ester 94916-96-8
Acetic acid, cyano(ethoxyethylidene)-, ethyl ester 64046-50-0
Acetic acid, cyano-, ethyl ester 105-56-6
Acetic acid, cyano-, hexyl ester 13361-53-0
Acetic acid, cyano-, hydrazide 140-87-4
Acetic acid, cyano-, (o-hydroxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-,(4-hydroxy-3-methoxybenzylidene)hydrazide 140-87-4
Acetic acid, cyano-, isobutyl ester 13361-31-4
Acetic acid, cyano-, isopropyl ester 13361-30-3
Acetic acid, cyano-, 2-methoxyethyl ester 10258-54-5
Acetic acid, 2-(4-biphenylyl)-2-methyl-,2-piperidinoethyl ester 64046-66-8
Acetic acid,((2-cyano-3-(methylamino)phenyl)amino)oxo-,monosodium salt 63365-44-6
Acetic acid, cyano-, methyl ester 105-34-0
Acetic acid, cyano((3-methylphenyl)hydrazono)-, ethylester 3994-20-5
Acetic acid, cyano((4-methylphenyl)hydrazono)-, ethylester 6797-29-1
Acetic acid, cyano((3-methylphenyl)hydrazono)-,methyl ester 59061-89-1

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