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MSDS  : 2-Benzothiazolethiol
CAS  : 149-30-4
SYNONYMS  : * Benzothiazole-2-thione * 2(3H)-Benzothiazolethione * 2-Benzothiazolyl mercaptan * Captax * Kaptax * MBT * Mercaptobenzothiazole * 2-Mercaptobenzothiazole * 2-Merkaptobenzotiazol * 2-Merkaptobenzthiazol * NCI-C56519 * Pennac MBT powder * Rokon * Rotax * Sulfadene * USAF GY-3 * USAF XR-29 * Vulkacit mercapto
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DL6475000
CHEMICAL NAME : 2-Benzothiazolethiol
CAS REGISTRY NUMBER : 149-30-4
LAST UPDATED : 199710
DATA ITEMS CITED : 29
MOLECULAR FORMULA : C7-H5-N-S2
MOLECULAR WEIGHT : 167.25
WISWESSER LINE NOTATION : T56 BN DSJ CSH
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzothiazole-2-thione
* 2(3H)-Benzothiazolethione
* 2-Benzothiazolyl mercaptan
* Captax
* Kaptax
* MBT
* Mercaptobenzothiazole
* 2-Mercaptobenzothiazole
* 2-Merkaptobenzotiazol
* 2-Merkaptobenzthiazol
* NCI-C56519
* Pennac MBT powder
* Rokon
* Rotax
* Sulfadene
* USAF GY-3
* USAF XR-29
* Vulkacit mercapto

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
3,93,1976

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1270 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-1190-0987S

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068
Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 16,35,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1158 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >7940 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - changes in motor activity (specific assay)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 1,62,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : >2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535428

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12220 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 18 gm/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 97500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 174 gm/kg/86W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(107),44,1989

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 770 mg/kg/7D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - liver function tests impaired
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
14,221,1969

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 195 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Gastrointestinal - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 215 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 195 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 800 mg/kg
SEX/DURATION : male 2 day(s) pre-mating
female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 93,107,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 400 mg/kg
SEX/DURATION : female 4-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 93,107,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 4176 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160

** MUTATION DATA **

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 351 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988

*** REVIEWS ***

TOXICOLOGY REVIEW
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
Volume(issue)/page/year: 15,808,1973

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84030
No. of Facilities: 2428 (estimated)
No. of Industries: 45
No. of Occupations: 40
No. of Employees: 42637 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84030
No. of Facilities: 4825 (estimated)
No. of Industries: 74
No. of Occupations: 62
No. of Employees: 86509 (estimated)
No. of Female Employees: 16409 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis Studies (gavage);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,88

NTP Carcinogenesis Studies (gavage);equivocal evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,88


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Benzothiazole,5-methoxy-2-(beta-(1-pyrrolidinyl)-p-phenetidino)- 38519-94-7
Benzothiazole, 2-methyl- 120-75-2
Benzothiazole, 2-(methylamino)- 16954-69-1
Benzothiazole, 6-((p-(methylamino)phenyl)azo)- 16954-69-1
Benzothiazole,2-(2-((1-methylethyl)thio)-4-thiazolyl)- 67723-95-9
Benzothiazole, 2-(3-methyl-1-phenyl-1H-pyrazol-5-yl)- 43193-11-9
Benzothiazole, 2-(3-methyl-1H-pyrazol-5-yl)- 43193-11-9
Benzothiazole, 2-(2-(methylthio)-4-thiazolyl)- 67723-92-6
Benzothiazole, 2-(morpholinothio)- 102-77-2
p-Benzoquinone,2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)- 800-24-8
p-Benzoquinone, 2,6-dimethoxy-3-(hydroxymethyl)-,acetate (ester) 40870-53-9
Benzothiazole, 2-(4-morpholinyldithio)- 95-32-9
Benzothiazole, 6-nitro-2-(p-nitrobenzoylamino)- 64036-74-4
Benzothiazole, 2-(2-nitrophenyl)- 6269-45-0
Benzothiazole, 2-pentylthio- 73713-86-7
Benzothiazole, 2-phenyl- 883-93-2
Benzothiazole, 6-((p-piperidinophenyl)azo)- 84713-38-2
Benzothiazole, 2-(piperidinothio)- 26773-65-9
3(2H)-Benzothiazolepropanamide,2-imino-6-(trifluoromethoxy)- 130997-38-5
3(2H)-Benzothiazolepropanenitrile,2-imino-6-(trifluoromethoxy)-, ethanedioate (1:1) 130997-37-4
3-Benzothiazolepropanesulfonic acid,2-(4-(3-ethyl-4-oxo-2-thioxo-5-thiazolidinylidene)-2-butenylidene)- 64285-53-6
p-Benzoquinone,2,3-dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)- 303-97-9
3(2H)-Benzothiazolepropanoic acid,2-(4-(3-(2-carboxyethyl)-4-oxo-2-thioxo-5-thiazolidinylidene)-2-butenylidene)-6-methyl- 62883-67-4
5-Benzothiazolepropionic acid, 2-phenyl- 52321-54-7
Benzothiazole, 2-(2-(propylthio)-4-thiazolyl)- 67723-94-8
Benzothiazole, 2-(2-pyridyl)- 716-80-3
Benzothiazole, 6-((p-(1-pyrrolidinyl)phenyl)azo)- 716-80-3
2-Benzothiazolesulfenamide 2801-21-0
2-Benzothiazolesulfenamide, N-tert-butyl- 95-31-8
2-Benzothiazolesulfenamide, N-cyclohexyl- 95-33-0
2-Benzothiazolesulfenamide, N,N-dicyclohexyl- 4979-32-2
2-Benzothiazolesulfenamide, N,N-diisopropyl- 95-29-4
p-Benzoquinone, 2,3-dimethyl- 526-86-3
2-Benzothiazolesulfonamide, 6-ethoxy- 452-35-7
Benzothiazolesulfonamide, N-(1-methylethyl)- 63904-87-0
7-Benzothiazolesulfonic acid,2-(p-aminophenyl)-6-methyl- 130-17-6
7-Benzothiazolesulfonic acid,2,2'-(1-triazene-1,3-diyldi-4,1-phenylene)bis(6-methyl-, disodium salt 1829-00-1
Benzothiazole, 4,5,6,7-tetrahydro-2-amino- 2933-29-1
Benzothiazole, 4,5,6,7-tetrahydro-,1,2-ethanedisulfonate (2:1) 31784-85-7
Benzothiazole, 4,5,6,7-tetrahydro-6-(methylamino)- 70590-58-8
Benzothiazole,4,5,6,7-tetrahydro-2-(2-(5-nitrofuryl)vinyl)- 30311-48-9
Benzothiazole,4,5,6,7-tetrahydro-2-(2-(5-nitrofuryl)vinyl)-,3-oxide 40019-78-1
2-Benzothiazolethiol 149-30-4
p-Benzoquinone, 2,5-dimethyl- 137-18-8
2-Benzothiazolethiol, 6-amino- 7442-07-1
2-Benzothiazolethiol, 5-chloro- 5331-91-9
2-Benzothiazolethiol, 6-ethoxy- 120-53-6
Benzothiazolethiol, 2-ethoxycarbonylmethyl- 64036-42-6
Benzothiazolethiol, 2-methyl- 64036-43-7
2-Benzothiazolethiol, 6-nitro- 4845-58-3

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