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MSDS  : 1,4-Butanediol
CAS  : 110-63-4
SYNONYMS  : * Agrisynth B1D * Butanediol * Butane-1,4-diol * 1,4-Butylene glycol * 1,4-Dihydroxybutane * DIOL 14B * Sucol B * Tetramethylene 1,4-diol * 1,4-Tetramethylene glycol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : EK0525000
CHEMICAL NAME : 1,4-Butanediol
CAS REGISTRY NUMBER : 110-63-4
BEILSTEIN REFERENCE NO. : 1633445
REFERENCE : 4-01-00-02515 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C4-H10-O2
MOLECULAR WEIGHT : 90.14
WISWESSER LINE NOTATION : Q4Q
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Agrisynth B1D
* Butanediol
* Butane-1,4-diol
* 1,4-Butylene glycol
* 1,4-Dihydroxybutane
* DIOL 14B
* Sucol B
* Tetramethylene 1,4-diol
* 1,4-Tetramethylene glycol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:
3,110,1948

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Rectal
SPECIES OBSERVED : Human - man
DOSE/DURATION : 429 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:
3,110,1948

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1525 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Blood - other changes
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(1-3),41,1968

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 gm/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 3,379,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 26,597,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2062 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Blood - other changes
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(1-3),41,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
49,385,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2531 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Blood - other changes
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(1-3),41,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Blood - other changes
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(1-3),41,1968

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5460 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Metabolism (Intermediary) - other carbohydrates
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 33(1),37,1968

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14 gm/kg/28D-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
PJOMEY Polish Journal of Occupational Medicine. (Polish Journal of
Occupational Medicine, P.O. Box 199, 90-950 Lodz, Poland) V.1-3; 1988-90.
Discontinued. Volume(issue)/page/year: 3,421,1990

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5200 mg/m3/6H/2W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 3,379,1991

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0752
No. of Facilities: 226 (estimated)
No. of Industries: 7
No. of Occupations: 22
No. of Employees: 16785 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0752
No. of Facilities: 759 (estimated)
No. of Industries: 21
No. of Occupations: 25
No. of Employees: 16811 (estimated)
No. of Female Employees: 3870 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Toxicity studies, RPT# TOX-54, October 1997


*** END OF RECORD ***
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NAMECAS
Biuret, 2,4-dithio-1-(m-methoxyphenyl)- 150-49-2
Butanedioic acid,mono(7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl) ester, monosodium salt, (+-)- 35888-86-9
Butanedioic acid,mono(2-(2-(2-(3-chlorophenyl)ethyl)phenoxy)-1-((dimethylamino)methyl) ethyl) ester, hydrochloride 86819-22-9
Butanedioic acid,mono(2-(4-chloro-2-(2-phenylethyl)phenoxy)-1-((dimethylamino)methyl) ethyl) ester, hydrochloride 86819-23-0
Butanedioic acid,mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2- benzodioxepin-10-yl)ester, sodium salt,(3R-(3-alpha,5a-beta,6-beta,8a-beta,9-alpha,10-alpha,12-beta,12aR*))- 82864-68-4
Butanedioic acid,mono(1-((diethylamino)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester 82864-68-4
Butanedioic acid,mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-yl) ester,(2R-(2R*(4R*,8R*)))- 4345-03-3
Butanedioic acid, mono(2-(dimethylamino)-1-((2-(2-(4-(dimethylamino)phenyl)ethyl)phenoxy)methyl)ethyl)ester, dihydrochloride 86819-19-4
Butanedioic acid,mono(2-(dimethylamino)-1-((2-(2-(3-fluorophenyl)ethyl)phenoxy)methyl) ethyl) ester, hydrochloride 86819-21-8
Butanedioic acid,mono(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl) ethyl) ester, hydrochloride 86819-20-7
Butanedioic acid,mono(1-((dimethylamino)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester, hydrochloride 86819-18-3
Biuret, 2,4-dithio-1-(p-methoxyphenyl)-5-phenyl- 86819-18-3
Butanedioic acid,mono(1-((dimethylamino)methyl)-2-(2-(2-(3-methoxyphenyl)ethyl)-4- chlorophenoxy)ethyl) ester,monohydrochloride 86819-18-3
Butanedioic acid,mono(1-((dimethylamino)methyl)-2-(2-(2-(3-methoxyphenyl)ethyl)phenoxy)ethy l)ester, monohydrochloride 86819-18-3
Butanedioic acid,mono(2-(1,4-dioxo-4-((5-propyl-1,3,4-thiadiazol-2-yl)amino)butyl)hydrazide) 124840-99-9
Butanedioic acid,mono(2-(1,4-dioxo-4-((2-thiazolylamino)butyl)hydrazide) 124841-02-7
Butanedioic acid, mono(4-hydroxy-3-sulfophenyl)ester,compd. with pyridine (1:1) 59687-27-3
Butanedioic acid,mono(16-methyl-2,5-dioxooxacyclohexadec-3-en-6-yl)ester 56448-20-5
Butanedioic acid,mono(1-((4-methyl-1-piperazinyl)methyl)-2-(2-(2-phenylethyl)phenoxy) ethyl) ester, hydrochloride 56448-20-5
Butanedioic acid,mono(1-((4-methyl-1-piperidinyl)methyl)-2-(2-(2-phenylethyl)phenoxy) ethyl) ester 56448-20-5
Butanedioic acid,mono(1-((2-(2-phenylethyl)phenoxy)methyl)-2-(1-piperidinyl)ethyl) ester, hydrochloride 86819-29-6
Butanedioic acid,mono(1-((2-(2-phenylethyl)phenoxy)methyl)-2-(1-pyrrolidinyl)ethyl) ester 86819-29-6
Biuret, 2,4-dithio-1-(1-naphthyl)- 86819-29-6
Butanedioic acid, oxo-, diethyl ester, ion(1-),sodium 40876-98-0
Butanedioic acid, phenyl-, 1-cyclohexyl4-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl) ester,ethanedioate (1:1) 114648-88-3
Butanedioic acid, 2-phenyl-,4-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl) 1-(2-methylpropyl) ester, ethanedioate (1:1) 114648-86-1
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl)ester,sodium salt, mixt. with 1,8-dihydroxy-9,10-anthracenedione 8059-64-1
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl)ester, sodium salt, mixt. with(2-pyridinylmethylene)di-4,1-phenylene diacetate andrhubarb extract 66813-55-6
Butanedioic acid, sulfo-, 1,4-dicyclohexyl ester,sodium salt 23386-52-9
Butanedioic acid, sulfo-, 1,4-dihexadecyl ester,sodium salt, mixt with 1,4-dioctadecylsulfobutanedioate sodium salt 90509-96-9
1,2-Butanediol 584-03-2
1,3-Butanediol 107-88-0
1,4-Butanediol 110-63-4
Biuret, 2,4-dithio-3-phenyl-1,1,5,5-tetramethyl- 33812-14-5
2,3-Butanediol 513-85-9
1,3-Butanediol,1-(p-anisyl)-2-methyl-4,4,4-trifluoro-3-(trifluoromethyl)- 34848-35-6
1,4-Butanediol, bis(1-aziridinepropionate) 25926-34-5
2,3-Butanediol,1,4-bis((4,5-dihydro-5-methyl-2-thiazolyl)amino)-,dihydrochloride 111915-72-1
2,3-Butanediol, 1,4-bis((2-mercaptoethyl)amino)-,dihydrochloride 18239-81-1
2,3-Butanediol,2,3-bis(trifluoromethyl)-1,1,1,4,4,4-hexafluoro- 918-21-8
1,2-Butanediol, 4-bromo-4,4-dinitro-1-phenyl- 63732-27-4
1,3-Butanediol,1-(p-bromophenyl)-2-methyl-3-trifluoromethyl-4,4,4-trifluoro- 34848-34-5
1,3-Butanediol, 4-(butylnitrosoamino)- 62018-91-1
1,3-Butanediol,4-chloro-3-chlorodifluoromethyl-4,4-difluoro-1-(2-furyl)- 34848-39-0
Biuret, 2,4-dithio-1-(p-propylphenyl)- 34848-39-0
1,3-Butanediol,4-chloro-3-(chlorodifluoromethyl)-4,4-difluoro-2-methyl-1-phenyl- 34848-27-6
1,3-Butanediol,4-chloro-3-chlorodifluoromethyl-4,4-difluoro-1-(2-thienyl)- 34848-40-3
1,3-Butanediol,1-(p-chlorophenyl)-2-ethyl-3-(trifluoromethyl)-4,4,4-trifluoro- 34848-31-2
2,3-Butanediol, 2-(m-chlorophenyl)-3-methyl- 13980-94-4
2,3-Butanediol, 2-(p-chlorophenyl)-3-methyl- 79-93-6

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