Butanedioic acid, compd. with
N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethana
mine (1:1),mixt. with
2-(diethylamino)ethyl(1,1'-bicyclohexyl)-1-carboxylat
e hydrochloride and 5-
hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
CAS
:
8064-77-5
SYNONYMS
:
* Debendox
* Lenotan
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EJ9960000
CHEMICAL NAME : Butanedioic acid, compd. with
N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethana
mine (1:1),mixt. with
2-(diethylamino)ethyl(1,1'-bicyclohexyl)-1-carboxylat
e hydrochloride and 5-
hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
CAS REGISTRY NUMBER : 8064-77-5
LAST UPDATED : 199806
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C19-H35-N-O2.C17-H22-N2-O.C8-H11-N-O3.C4-H6-O4.2Cl-H
MOLECULAR WEIGHT : 940.18
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Debendox
* Lenotan
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 75600 ug/kg
SEX/DURATION : female 6-11 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,691,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 67 mg/kg
SEX/DURATION : female 4-20 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,925,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 60 mg/kg
SEX/DURATION : female 4-18 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,691,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 60 mg/kg
SEX/DURATION : female 4-18 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,691,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 648 mg/kg
SEX/DURATION : female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,691,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 648 mg/kg
SEX/DURATION : female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,691,1978
*** END OF RECORD ***
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