* Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt,
(3-alpha,5-beta,7-alpha,12-alpha)-
* Cholic acid, monosodium salt
* DS-Na
* Sodium cholate
* Sodium cholic acid
* Trihydroxy 3-7-12 cholanate de Na
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FZ9600000
CHEMICAL NAME : Cholic acid, sodium salt
CAS REGISTRY NUMBER : 361-09-1
LAST UPDATED : 199701
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C24-H39-O5.Na
MOLECULAR WEIGHT : 430.62
WISWESSER LINE NOTATION : L E5 B666TJ A1 DQ E1 FY1&2VO KQ OQ &-NA- &38/28
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt,
(3-alpha,5-beta,7-alpha,12-alpha)-
* Cholic acid, monosodium salt
* DS-Na
* Sodium cholate
* Sodium cholic acid
* Trihydroxy 3-7-12 cholanate de Na
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(103),29,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 164 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(103),29,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 90,18,1952
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 52,779,1926
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1798
No. of Facilities: 82 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 82 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1798
No. of Facilities: 585 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 6463 (estimated)
No. of Female Employees: 4599 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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