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MSDS  : Choline, compd. with theophylline (11)
CAS  : 4499-40-5
SYNONYMS  : * Choledyl * Choledyl SA 400 * Cholegyl * Choline theophyllinate * Choline theophylline salt * Cholinophylline * Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethylpurine-2,6-dione * Filoral * (2-Hydroxyethyl)trimethylammonium compound with theophylline * Oxtrimethylline * Oxtriphylline * Soliphylline * Teofilcolina * Teokolin * Theophylline cholinate * Theophylline salt of choline * Theoxylline
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GA7420000
CHEMICAL NAME : Choline, compd. with theophylline (1:1)
CAS REGISTRY NUMBER : 4499-40-5
OTHER CAS REGISTRY NOS. : 146-71-4
LAST UPDATED : 199504
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C7-H7-N4-O2.C5-H14-N-O
MOLECULAR WEIGHT : 283.38
WISWESSER LINE NOTATION : T56 BM DN FNVNVJ F H &622
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Choledyl
* Choledyl SA 400
* Cholegyl
* Choline theophyllinate
* Choline theophylline salt
* Cholinophylline
* Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with
3,7-dihydro-1,3-dimethylpurine-2,6-dione
* Filoral
* (2-Hydroxyethyl)trimethylammonium compound with theophylline
* Oxtrimethylline
* Oxtriphylline
* Soliphylline
* Teofilcolina
* Teokolin
* Theophylline cholinate
* Theophylline salt of choline
* Theoxylline

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 429 mg/kg
TOXIC EFFECTS :
Endocrine - hyperglycemia
Nutritional and Gross Metabolic - changes in potassium
Nutritional and Gross Metabolic - metabolic acidosis
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia,
PA) V.1- 1983- Volume(issue)/page/year: 3,408,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - infant
DOSE/DURATION : 113 mg/kg/31D
TOXIC EFFECTS :
Endocrine - hyperglycemia
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year:
53,757,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 420 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 71,965,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,278,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 185 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,278,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,278,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 185 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81445
No. of Facilities: 833 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 7077 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81445
No. of Facilities: 168 (estimated)
No. of Industries: 2
No. of Occupations: 12
No. of Employees: 9561 (estimated)
No. of Female Employees: 7717 (estimated)


*** END OF RECORD ***
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NAMECAS
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Choline, beta-methyl-, methylether, hydrochloride 63938-96-5
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Choline, compd. with1-methyl-3-phenethyl-6-thioxanthine (1:1) 63938-96-5
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Choline, nitrate (ester), hydroxide 543-17-9
Choline nitrate (ester), nitrate 26511-30-8
Choline, nitrate, perchlorate 26511-30-8
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Choline, picrate, 3-pyridazineacrylate 110061-37-5
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Choline, salicylate 2016-36-6
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Choline, compd. with theobromine 306-40-1
Choline, compd. with theophylline (11) 4499-40-5
Choline, compd. with 6-thiotheobromine (11) 4499-40-5
Choline, compd. with 6-thiotheophylline (11) 4499-40-5
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Chondrocurarine, 7'-O-methyl-, diiodide, trihydrate 2842-86-6

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