*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GG3200000
CHEMICAL NAME : Cobalt(II) sulfate (1:1), heptahydrate
CAS REGISTRY NUMBER : 10026-24-1
LAST UPDATED : 199712
DATA ITEMS CITED : 11
MOLECULAR FORMULA : Co-O4-S.7H2-O
MOLECULAR WEIGHT : 281.13
WISWESSER LINE NOTATION : .CO..S-O4 &QH 7
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cobalt monosulfate heptahydrate
* Cobaltous sulfate heptahydrate
* Cobalt(II) sulphate heptahydrate
* Sulfuric acid, cobalt(2+) salt (1:1), heptahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 582 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 1,688,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 13,94,1978
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 16200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 91 mg/m3/6H/16D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - chromodacryorrhea
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Endocrine - changes in thymus weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3124
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18 mg/m3/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - pigmented or nucleated red blood cells
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3124
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 30 mg/m3/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Endocrine - effect on menstrual cycle
Related to Chronic Data - changes in testicular weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
15,357,1990
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 30 mg/m3/6H
SEX/DURATION : male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
15,357,1990
** MUTATION DATA **
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 392,61,1997
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2377
No. of Facilities: 126 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 3264 (estimated)
No. of Female Employees: 1853 (estimated)
*** STATUS IN U.S. ***
NTP Toxicity studies, RPT# TOX-05, October 1997
NTP Carcinogenesis studies; test completed (post peer review), October 1997
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Cobalt I, (dihydrogen7,12-diethyl-3,8,13,17-tetramethyl-2,18-porphinedipropionato(2-))-
| 21158-51-0 |
Cobalt,(ethanedioato(2-)-O,O')bis(3-methylbenzenamine)-
| 80660-64-6 |
C.I. Vat Brown 53
| 61902-47-4 |
Cobalt,(ethanedioato(2-)-O,O')bis(3-((phenylamino)methyl)-2(3H)-benzoxazolone- N(sup N(sup 3),O(sup 2))-
| 82497-97-0 |
Cobalt, (ethanedioato(2-)-O,O')bis(pyridine1-oxide-O)-, (T-4)-
| 74167-21-8 |
Cobalt(II),N,N'-ethylenebis(3-fluorosalicylideneiminato)-
| 62207-76-5 |
Cobalt, N,N'-ethylenebis(salicylideneiminato)-
| 14167-18-1 |
Cobalt(II)fluoborate
| 26490-63-1 |
Cobalt(II) fluoride
| 10026-17-2 |
Cobalt(3+), hexaammine-, (OC-6-11)-, triacetate
| 14023-85-9 |
Cobalt hydrocarbonyl
| 16842-03-8 |
Cobalt hydroxide
| 1307-86-4 |
Cobalt(II) hydroxide
| 21041-93-0 |
Citric acid, triethyl ester
| 77-93-0 |
Civet absolute
| 68916-26-7 |
Cobalt hydroxide oxide
| 12016-80-7 |
Cobalt, complex with niacinamide
| 12016-80-7 |
Cobalt(II) nitrate (12)
| 10141-05-6 |
Cobalt oxide (Co3O4)
| 1308-06-1 |
Cobalt(2+) oxide
| 1307-96-6 |
Cobalt(III) oxide
| 1308-04-9 |
Cobalt(II) perchlorate, hexahydrate
| 13478-33-6 |
Cobalt(II) sulfate (11)
| 10124-43-3 |
Cobalt(II) sulfate (11), heptahydrate
| 10026-24-1 |
Cobalt sulfide
| 12013-10-4 |
Cladomycin
| 100927-16-0 |
Cobalt(2+) sulfide
| 1317-42-6 |
Cobalt, triammine(2-oxopentanedioato(2-)-O(sup1),O(sup 2),O(sup 5))-
| 132829-10-8 |
Cobalt, tri-mu-carbonylnonacarbonyltetra-,tetrahydro-
| 17786-31-1 |
Cobalt(3+), tris(2,2'-bipyridine-N,N')-, perchlorate(1:3), (OC-6-11)-
| 14376-02-4 |
Cobalt(2+), tris(1,2-ethanediamine-N,N')-,(OC-6-11)-, (T-4)-tetraoxotungstate(2-) (1:1),pentahydrate
| 80669-48-3 |
Cobalt, tris(octamethylpyrophosphoramide)-,diperchlorate(1-)
| 80669-48-3 |
Cobalt(2+), tris(octamethylpyrophosphoramide)-,diperchlorate
| 26167-79-3 |
Cobalt(2+), tris(1,2-propanediamine-N,N')-,(T-4)-tetraoxotungstate(2-) (1:1), pentahydrate
| 80660-43-1 |
Cobinamide, acetate (salt) hydroxide, dihydrogenphosphate (ester), inner salt, 3'-ester with5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
| 22465-48-1 |
Cobinamide, cobalt-methyl derivative, hydroxide,dihydrogen phosphate (ester), inner salt, 3'-esterwith5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
| 13422-55-4 |
Clarified slurry oil
| 64741-62-4 |
Cobinamide, cyanide phosphate 3'-ester with5,6-dimethyl-1-alpha-D- ribofuranosylbenzimidazole,inner salt
| 68-19-9 |
Cobinamide, O-(5'-deoxyadenosine-5') deriv.,hydroxide, dihydrogen phosphate (ester), inner salt,3'-ester with5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
| 13870-90-1 |
Cobinamide, dihydroxide, dihydrogen phosphate(ester), mono (inner salt), 3'- ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
| 13422-51-0 |
Cobramin ASUBSTANCE DEFINITION :Isolated from the venom of Naja najaREFERENCE :BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,Fairview Park, Elmsford, NY 10523) V.1- 1958-
| 13422-51-0 |
Cobramin B
| 12777-56-9 |
Cobrotoxin
| 12584-83-7 |
Coca leaf, extract
| 12584-83-7 |
Coccinia grandis (L.)Voigt, extractSUBSTANCE DEFINITION :Plant belonging to the family CucurbitaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 12584-83-7 |
Coccinia indica W. & A., root extractSUBSTANCE DEFINITION :Plant belonging to the family CucurbitaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 12584-83-7 |
Cocculus hirsutus (linn.) Diels, extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family MenispermaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 12584-83-7 |
Clary sage oil
| 8016-63-5 |
Cocculus laurifolius DC., extractSUBSTANCE DEFINITION :Plant belonging to the family MenispermaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 8016-63-5 |
Cocculus pendulus (forst) Diels, extractSUBSTANCE DEFINITION :Plant belonging to the family MenispermaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979-
| 8016-63-5 |
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