*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GM7925000
CHEMICAL NAME : Corticotropin-releasing factor (sheep), 2-L-glutamic
acid-22-L-alanine-23-L-arginine- 25-L-glutamic
acid-38-L-methionine-39-L-glutamic
acid-41-L-isoleucinamide-
CAS REGISTRY NUMBER : 86784-80-7
LAST UPDATED : 199510
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C208-H344-N60-O63-S2
MOLECULAR WEIGHT : 4758.24
COMPOUND DESCRIPTOR : Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* Corticobiss
* Corticotropin-releasing factor (horse)
* Corticotropin-releasing factor (human)
* Corticotropin-releasing factor (rat)
* Corticotropin-releasing hormone (human)
* CRF 41
* Human corticotropin-releasing factor
* Human corticotropin-releasing hormone
* Human corticotropin-releasing hormone-41
* Human CRF
* Human CRF (1-41)
* MCI 028
* Rat ACTH-releasing hormone
* Rat corticotropin-releasing factor
* Rat corticotropin-releasing factor-41
* Rat CRF
* Rat CRF(1-41)
* Rat hypothalamic CRF
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1241,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >1 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1241,1992
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 560 ug/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in spleen
Blood - changes in leukocyte (WBC) count
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1263,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 840 ug/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Endocrine - changes in thymus weight
Related to Chronic Data - changes in uterine weight
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1287,1992
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 1148 ug/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1313,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 3111 ug/kg
SEX/DURATION : male 61 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1313,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 2700 ug/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 20(Suppl 5),S1349,1992
*** END OF RECORD ***
|
|
|
| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Cordia obligua Willd., extract excluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family EhretiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 93195-32-5 |
|
Cordia rothii Roem. & Schult., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family BoraginaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 93195-32-5 |
|
Clerodendrum colebrookianum Walp., extractSUBSTANCE DEFINITION :Plant belonging to the family VerbenaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 93195-32-5 |
|
Cordia verbenacea DC, leaf extractSUBSTANCE DEFINITION :Plant belonging to the family BoraginaceaeREFERENCE :PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 54,7,1988
| 93195-32-5 |
|
Cordia vestita Hook. f. & Thoms., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family BoraginaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 93195-32-5 |
|
Cordia wallichii G. Don, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family EbretiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 93195-32-5 |
|
Cordyceps sinensis (berk) Sacc., extract
| 93195-32-5 |
|
Corexit 9527
| 60617-06-3 |
|
Coriamyrtin
| 2571-86-0 |
|
Coriander oil
| 8008-52-4 |
|
Coriandrum sativum, seed extract
| 8008-52-4 |
|
Coriaria nepalensis Wall., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family CoriariaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 8008-52-4 |
|
Coriolan-33SUBSTANCE DEFINITION :Isolated from Polistictus versicolor and Coriolus versicolorREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,58,1980
| 8008-52-4 |
|
Clerodendrum bracteatum Wall., extractSUBSTANCE DEFINITION :Plant belonging to the family VerbenaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 8008-52-4 |
|
Cornmint oil
| 68917-18-0 |
|
Corn oil
| 8001-30-7 |
|
Corn oil, brominated
| 92113-32-1 |
|
Corn oil, chlorinated
| 104639-44-3 |
|
Corn starch
| 9005-25-8 |
|
Cornus capitata Wall. ex Roxb., leaf extractSUBSTANCE DEFINITION :Plant belonging to the family CornaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 9005-25-8 |
|
Cornus macrophylla Wall., extractSUBSTANCE DEFINITION :Plant belonging to the family CornaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 9005-25-8 |
|
Coronene
| 191-07-1 |
|
Coronene, 1-nitro-
| 81316-84-9 |
|
Coronopus didymus (Linn.) Sm., extractSUBSTANCE DEFINITION :Plant belonging to the family CruciferaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,228,1978
| 81316-84-9 |
|
Clerodendrum fragrans Vent., extractSUBSTANCE DEFINITION :Plant belonging to the family VerbenaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 81316-84-9 |
|
Coronopus didymus (linn.) Smith, extractSUBSTANCE DEFINITION :Plant belonging to the family BrassicaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 81316-84-9 |
|
Corotoxigenin-rhamnose
| 58917-39-8 |
|
Corticosterone
| 50-22-6 |
|
Corticosterone, 21-acetate
| 1173-26-8 |
|
Corticotropin
| 9002-60-2 |
|
alpha(sup 1-24)-Corticotropin
| 16960-16-0 |
|
alpha(1-24)-Corticotropin, acetate (salt)
| 60189-34-6 |
|
alpha(1-18)-Corticotropin,1-glycine-18-L-argininamide-, monoacetate (salt)
| 57355-81-4 |
|
Corticotropin-releasing factor (sheep), 2-L-glutamicacid-22-L-alanine-23-L-arginine- 25-L-glutamicacid-38-L-methionine-39-L-glutamicacid-41-L-isoleucinamide-
| 86784-80-7 |
|
alpha(sup 1-24)-Corticotropin mixt. with zincphosphate (3:2)
| 53468-06-7 |
|
Clerodendrum indicum (L.) Kuntze, extractSUBSTANCE DEFINITION :Plant belonging to the family VerbenaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 53468-06-7 |
|
Cortinarius orellanus (fries), mushroom homogenate
| 53468-06-7 |
|
Cortinarius speciosissimus (khun & Romagn), mushroomhomogenate
| 53468-06-7 |
|
Cortisol
| 50-23-7 |
|
Cortisol, 21-acetate
| 50-03-3 |
|
Cortisol, 17-butyrate
| 13609-67-1 |
|
Cortisol, 21-butyrate
| 6677-99-2 |
|
Cortisol, 17-butyrate, 21-propionate
| 72590-77-3 |
|
Cortisol, 21-(dihydrogen phosphate)
| 3863-59-0 |
|
Cortisol, 21-(dihydrogen phosphate), disodium salt
| 6000-74-4 |
|
Cortisol, succinate, sodium salt
| 125-04-2 |
|
Clerodendrum inerme (L.) Gaertn., extractSUBSTANCE DEFINITION :Plant belonging to the family VerbenaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 125-04-2 |
|
Cortisone
| 53-06-5 |
|
Cortisone 21-acetate
| 50-04-4 |
|
Corundum
| 1302-74-5 |
|
|