*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GW4570000
CHEMICAL NAME : 3-Cyclohexene-1-carboxylic acid, 2-phenyl-,
2-dimethylaminoethyl ester, hydrochloride
LAST UPDATED : 199506
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C17-H23-N-O2.Cl-H
MOLECULAR WEIGHT : 309.87
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* beta-Dimethylaminoethyl-2-phenyltetrahydrobenzoate hydrochloride
* 2-Phenyl-3-cyclohexene-1-carboxylic acid 2-dimethylaminoethyl ester
hydrochloride
* S 187
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >267 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 267 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 27 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : >50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam,
Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ.
Volume(issue)/page/year: 1,4,1950
*** END OF RECORD ***
|
|
|