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MSDS  : 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, hydrochloride, trans-(+-)-
CAS  : 27107-79-5
SYNONYMS  : * dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaeth ylester HCl * dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-ene-trans-carbonic acid ethyl ester HCl * Ethyl DL-trans-2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate * (+-)-Ethyl-trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate hydrochloride * GO-1261 * Go 1261 C * Tilidate * Tilidine hydrochloride * DL-trans,trans-Tildine hydrochloride * Valoron * Valoron hydrochloride * W 5759A
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GW4375000
CHEMICAL NAME : 3-Cyclohexene-1-carboxylic acid,
2-(dimethylamino)-1-phenyl-, ethyl ester,
hydrochloride, trans-(+-)-
CAS REGISTRY NUMBER : 27107-79-5
LAST UPDATED : 199012
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C17-H23-N-O2.Cl-H
MOLECULAR WEIGHT : 309.87
WISWESSER LINE NOTATION : L6UTJ CN1&1 DVO2 DR &GH
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaeth
ylester HCl
* dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-ene-trans-carbonic acid
ethyl ester HCl
* Ethyl DL-trans-2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate
* (+-)-Ethyl-trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate
hydrochloride
* GO-1261
* Go 1261 C
* Tilidate
* Tilidine hydrochloride
* DL-trans,trans-Tildine hydrochloride
* Valoron
* Valoron hydrochloride
* W 5759A

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 418 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 74 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 437 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 490 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 52 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1450 mg/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,983,1970

*** END OF RECORD ***
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NAMECAS
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3-Cyclohexene-1-carboxaldehyde,4-(4-hydroxy-4-methylpentyl)- 31906-04-4
1-Cyclohexene-1-carboxaldehyde, 4-isopropenyl- 2111-75-3
1-Cyclohexene-1-carboxaldehyde, 4-isopropenyl-,(S)-(-)- 18031-40-8
1-Cyclohexene-1-carboxaldehyde, 4-isopropenyl-,anti-oxime 30950-27-7
3-Cyclohexene-1-carboxaldehyde, 6-methyl- 89-94-1
3-Cyclohexene-1-carboxaldehyde,1-methyl-4-(4-methylpentyl)- 66327-54-6
3-Cyclohexene-1-carboxaldehyde,4-(5-methyl-3-penten-1-yl)- 80450-04-0
3-Cyclohexene-1-carboxaldehyde, 2,4,6-trimethyl-, and3,5,6-trimethyl-3-cyclohexene-1- carboxaldehyde 1335-66-6
3-Cyclohexene-1-carboxamide, 1,4-dimethyl- 69352-88-1
1-Cyclohexene-1-carboxamide,2-hydroxy-N-(5-methyl-3-isoxazolyl)-4,6-dioxo-3,3,5,5-tetra- 2-propenyl-, monosodium salt 69352-88-1
Cyclohexanecarboxamide,N-(2-(7-methoxy-1-naphthalenyl)ethyl)- 138113-02-7
3-Cyclohexene-1-carboxamide, 1-methyl- 69352-89-2
3-Cyclohexenecarboxamide, thio- 64011-70-7
3-Cyclohexene-1-carboxylic acid 4771-80-6
3-Cyclohexene-1-carboxylic acid,4-((4-bromophenyl)amino)-6-methyl-2-oxo-, ethyl ester 149221-21-6
2-Cyclohexene-1-carboxylic acid,2-(4-carboxy-3-methyl-1,3-butadienyl)-1,3-dimethyl-4-oxo-, (E,E)- 67192-53-4
3-Cyclohexene-1-carboxylic acid,4-((4-chlorophenyl)amino)-6-methyl-2-oxo-, ethylester 149221-20-5
3-Cyclohexene-1-carboxylic acid,4-((4-chlorophenyl)amino)-6-methyl-2-oxo-, methylester 142458-16-0
3-Cyclohexene-1-carboxylic acid,4-((5-chloro-2-pyridinyl)amino)-6-methyl-2-oxo-,methyl ester 149221-14-7
3-Cyclohexene-1-carboxylic acid,(2-cyclohexenyl)methyl ester 64011-52-5
3-Cyclohexene-1-carboxylic acid,6-(((2-(((2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-3-yl) carbonyl)amino)ethyl)amino)carbonyl)- 93799-09-8
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3-Cyclohexene-1-carboxylic acid,6-(((3-(((2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-3-yl) carbonyl)amino)propyl)amino)carbonyl)- 93799-10-1
1-Cyclohexene-1-carboxylic acid,2-(2,4-dihydroxyphenyl)-, delta-lactone, O-ester withO,O- diethyl phosphorothioate 572-48-5
3-Cyclohexene-1-carboxylic acid,2-(dimethylamino)-1-phenyl-, ethyl ester,trans-(+-)-, (E)-2-butenedioate (1:1) 55567-81-2
3-Cyclohexene-1-carboxylic acid,2-(dimethylamino)-1-phenyl-, ethyl ester,hydrochloride, trans-(+-)- 27107-79-5
3-Cyclohexene-1-carboxylic acid,4-((4-(1,1-dimethylethyl)phenyl)amino)-6-methyl-2-oxo-, ethyl ester 149221-28-3
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3-Cyclohexene-1-carboxylic acid,5-ethyl-4-(p-hydroxyphenyl)-6-methyl-, acetate(ester) 21161-63-7
3-Cyclohexene-1-carboxylic acid,5-ethyl-4-(p-hydroxyphenyl)-6-methyl-, sodium salt 22921-18-2
3-Cyclohexene-1-carboxylic acid,3-ethyl-4-(p-methoxyphenyl)-2-methyl- 1755-52-8
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3-Cyclohexene-1-carboxylic acid,5-ethyl-6-methyl-4-phenyl-, sodium salt 16550-39-3
3-Cyclohexene-1-carboxylic acid,4-((4-ethylphenyl)amino)-6-methyl-2-oxo-, methylester 142458-15-9
1-Cyclohexene-1-carboxylic acid,2-((5-ethyl-1,3,4-thiadiazol-2-yl)amino)- 160893-96-9
3-Cyclohexene-1-carboxylic acid, 1-methyl- 16646-42-7
3-Cyclohexene-1-carboxylic acid, 2-methyl- 4736-19-0
3-Cyclohexene-1-carboxylic acid,2-(methylamino)-1-phenyl-, ethyl ester, trans-(+)- 37815-44-4
3-Cyclohexene-1-carboxylic acid,2-(methylamino)-1-phenyl-, ethyl ester, trans-(+)-,compd. with(R-(R*,R*))-2,3-bis(benzoyloxy)butanedioic acid 37815-44-4
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3-Cyclohexene-1-carboxylic acid,6-methyl-2-oxo-4-((4-(trifluoromethyl)phenyl)amino)-,ethyl ester 149221-29-4
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