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MSDS   | : | 3-Cyclohexene-1-carboxylic acid,
2-(dimethylamino)-1-phenyl-, ethyl ester,
hydrochloride, trans-(+-)-
| CAS   | : | 27107-79-5 | SYNONYMS   | : | * dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaeth
ylester HCl
* dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-ene-trans-carbonic acid
ethyl ester HCl
* Ethyl DL-trans-2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate
* (+-)-Ethyl-trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate
hydrochloride
* GO-1261
* Go 1261 C
* Tilidate
* Tilidine hydrochloride
* DL-trans,trans-Tildine hydrochloride
* Valoron
* Valoron hydrochloride
* W 5759A
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GW4375000
CHEMICAL NAME : 3-Cyclohexene-1-carboxylic acid,
2-(dimethylamino)-1-phenyl-, ethyl ester,
hydrochloride, trans-(+-)-
CAS REGISTRY NUMBER : 27107-79-5
LAST UPDATED : 199012
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C17-H23-N-O2.Cl-H
MOLECULAR WEIGHT : 309.87
WISWESSER LINE NOTATION : L6UTJ CN1&1 DVO2 DR &GH
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-en-trans-1-carbonsaeureaeth
ylester HCl
* dl-trans-2-Dimethylamino-1-phenyl-cyclohex-3-ene-trans-carbonic acid
ethyl ester HCl
* Ethyl DL-trans-2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate
* (+-)-Ethyl-trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate
hydrochloride
* GO-1261
* Go 1261 C
* Tilidate
* Tilidine hydrochloride
* DL-trans,trans-Tildine hydrochloride
* Valoron
* Valoron hydrochloride
* W 5759A
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 418 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 74 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 437 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 490 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 52 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,977,1970
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1450 mg/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,983,1970
*** END OF RECORD ***
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