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MSDS  : Ether, 2,2,2-trifluoroethyl vinyl
CAS  : 406-90-6
SYNONYMS  : * Ethene, (2,2,2-trifluoroethoxy)- * Floroxene * Fluooxene * Fluoromar * Fluoroxene * Fluorxene * Fluroxene * 2,2,2-Trifluoroethyl vinyl ether
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : KO4250000
CHEMICAL NAME : Ether, 2,2,2-trifluoroethyl vinyl
CAS REGISTRY NUMBER : 406-90-6
BEILSTEIN REFERENCE NO. : 1745876
REFERENCE : 4-01-00-02051 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C4-H5-F3-O
MOLECULAR WEIGHT : 126.09
WISWESSER LINE NOTATION : FXFF1O1U1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Ethene, (2,2,2-trifluoroethoxy)-
* Floroxene
* Fluooxene
* Fluoromar
* Fluoroxene
* Fluorxene
* Fluroxene
* 2,2,2-Trifluoroethyl vinyl ether

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2 pph/90M
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
Liver - liver function tests impaired
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
37,462,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
71,84,1983

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 pph/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year:
48,399,1976

** REPRODUCTIVE DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE : 8 pph/20M
SEX/DURATION : female 22 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub.,
POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
Volume(issue)/page/year: 20,183,1976

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,183,1978

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,183,1978

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 2 pph/1H
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
62,305,1985

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 24700 ppm
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
50,426,1979

*** REVIEWS ***

IARC Cancer Review:Animal No Adequate Data
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,93,1987

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-DENMARK:TWA 2 ppm (10 mg/m3) JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUROXENE-air:CL 2 ppm/60M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M5153
No. of Facilities: 112 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 448 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M5153
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 5 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: Body fluid assay

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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