*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KO4250000
CHEMICAL NAME : Ether, 2,2,2-trifluoroethyl vinyl
CAS REGISTRY NUMBER : 406-90-6
BEILSTEIN REFERENCE NO. : 1745876
REFERENCE : 4-01-00-02051 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C4-H5-F3-O
MOLECULAR WEIGHT : 126.09
WISWESSER LINE NOTATION : FXFF1O1U1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Ethene, (2,2,2-trifluoroethoxy)-
* Floroxene
* Fluooxene
* Fluoromar
* Fluoroxene
* Fluorxene
* Fluroxene
* 2,2,2-Trifluoroethyl vinyl ether
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2 pph/90M
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
Liver - liver function tests impaired
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
37,462,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
71,84,1983
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 pph/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year:
48,399,1976
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE : 8 pph/20M
SEX/DURATION : female 22 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub.,
POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
Volume(issue)/page/year: 20,183,1976
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,183,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,183,1978
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 2 pph/1H
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
62,305,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 24700 ppm
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year:
50,426,1979
*** REVIEWS ***
IARC Cancer Review:Animal No Adequate Data
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,93,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-DENMARK:TWA 2 ppm (10 mg/m3) JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUROXENE-air:CL 2 ppm/60M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M5153
No. of Facilities: 112 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 448 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M5153
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 5 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Ethanone,1-(4,5-dihydro-4-phenyl-5-(phenylmethyl)-5-(1-piperidinyl)-1,3,4-selenadia zol-2-yl)-
| 129801-24-7 |
Ether, trichlorophenyl
| 31242-93-0 |
Ether, (2-(triethoxysilylethyl)) vinyl
| 60627-12-5 |
Ether, 2,2,2-trifluoroethyl vinyl
| 406-90-6 |
Ether, trifluoromethyl trifluorovinyl
| 1187-93-5 |
Ether, 2,6,8-trimethylnonyl vinyl
| 10141-19-2 |
Ethesdamine
| 11029-29-1 |
Ethiodol
| 8008-53-5 |
3-Ethochloride of 9-dimethylamine 3-isophenothiazine
| 63918-80-9 |
Ethoduomeen
| 53127-17-6 |
Ethoduomeen, hydrofluoride
| 53127-17-6 |
Ethanone,1-(4,5-dihydro-4-phenyl-5-(phenylmethyl)-5-(1-piperidinyl)-1,3,4-thiadiazo l-2-yl)-
| 139617-46-2 |
Ethomeen C/l5
| 61791-14-8 |
Ethomeen S/l2
| 61791-24-0 |
Ethomeen S/l5
| 61791-24-0 |
Ethomeen T/15
| 61791-26-2 |
Ethyl alcohol
| 64-17-5 |
Ethylamine, 1-acetoxy-N-methyl-N-nitroso-
| 65986-79-0 |
Ethylamine,2-((6-allyl-1,4-benzodioxan-5-yl)oxy)-N-methyl-,hydrochloride
| 10312-87-5 |
Ethylamine,2-((6-allyl-7-chloro-1,4-benzodioxan-5-yl)oxy)-N-methyl-, hydrochloride
| 75264-55-0 |
Ethylamine,2-((8-allyl-6-chloro-1,4-benzodioxan-5-yl)oxy)-N-methyl-, hydrochloride
| 101418-22-8 |
Ethylamine, N-allyl-1-(p-(cyclohexyloxy)phenyl)-
| 73927-58-9 |
Ethanone,1-(2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-inden-5-yl)-, trans-
| 68857-95-4 |
Ethylamine, N-allyl-2-(2-cyclopentenyl)-1-methyl-
| 67238-63-5 |
Ethylamine, 2-(5-amino-1,3,4-thiadiazol-2-ylthio)-,hydrochloride
| 63503-53-7 |
Ethylamine, 2-(o-anisylthio)-N,N-diethyl-,hydrochloride
| 63918-81-0 |
Ethylamine, 2-(9-anthracenyl)-N,N-dimethyl-,hydrochloride
| 22682-80-0 |
Ethylamine, 2-azido-
| 87156-40-9 |
Ethylamine,2-(1,4-benzodioxan-5-yloxy)-N,N-dimethyl-,hydrochloride
| 2906-72-1 |
Ethylamine,2-(1,4-benzodioxan-6-yloxy)-N,N-dimethyl-,hydrochloride
| 3308-62-1 |
Ethylamine, 2-(1,4-benzodioxan-5-yloxy)-N-methyl-,hydrochloride
| 2906-66-3 |
Ethylamine, 2-(1,4-benzodioxan-6-yloxy)-N-methyl-,hydrochloride
| 2906-76-5 |
Ethylamine,beta-(o-benzyl-p-chlorophenoxy)-N,N-dimethyl-,hydrochloride
| 60634-52-8 |
Ethanone,2,2-dihydroxy-1-(4-((3-methylbutyl)thio)phenyl)-
| 53066-78-7 |
Ethylamine, 2,2'-(benzylidenedithio)bis-,dihydrochloride
| 22907-48-8 |
Ethylamine,2-((2-benzyl-1-indanyl)oxy)-N,N-dimethyl-,hydrochloride, trans-
| 14715-04-9 |
Ethylamine, 1-benzyl-N-methyl-2-phenyl-,hydrochloride
| 14715-04-9 |
Ethylamine, 2-(o-benzylphenoxy)-N,N-dimethyl-,hydrochloride
| 6152-43-8 |
Ethylamine, 2-(benzylthio)-, hydrochloride
| 22572-33-4 |
Ethylamine, N-bicyclo(3.1.0)hex-2-yl-1-methyl-,oxalate
| 101418-23-9 |
Ethylamine, N-bicyclo(3.1.0)hex-2-yl-, oxalate
| 79531-40-1 |
Ethylamine,2-(biphenylyl(phenyl)methoxy)-N,N-dimethyl-,hydrochloride
| 63919-06-2 |
Ethylamine,2-(bis(p-(butylthio)phenyl)methylthio)-N,N-dimethyl-
| 63919-06-2 |
Ethylamine,2-(bis(2,6-dimethylphenyl)methoxy)-N,N-dimethyl-,N-oxide, hydrochloride
| 35877-19-1 |
Ethanone, 1-(4-cyclopentylphenyl)-2-(1-piperidinyl)-,(Z)-2-butenedioate (1:1)
| 85689-91-4 |
Ethanone,2,2-dihydroxy-1-(4-((1-methylethyl)thio)phenyl)-
| 53066-76-5 |
Ethylamine,2-(2-(bis(2,6-dimethylphenyl)methoxy)ethoxy)-N,N-dimethyl-, maleate
| 53066-76-5 |
Ethylamine,2-(2-(bis(2,6-dimethylphenyl)methoxy)ethoxy)-N,N-dimethyl-, N-oxide, maleate
| 35852-19-8 |
Ethylamine,2-(bis(p-(hexylthio)phenyl)methylthio)-N,N-dimethyl-
| 35852-19-8 |
Ethylamine,2-(p-(1,2-bis(p-methoxyphenyl)-1-butenyl)phenoxy)-N,N-dimethyl-, hydrochloride
| 42824-29-3 |
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