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MSDS  : 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5- epoxy- 18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (5-alpha,7-alpha(S))-
CAS  : 53152-21-9
SYNONYMS  : * Buprenorphine hydrochloride * M-6029 * MR 56 * NIH 8805
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : KM7758000
CHEMICAL NAME : 6,14-Ethenomorphinan-7-methanol,
17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-
epoxy-
18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-,
hydrochloride, (5-alpha,7-alpha(S))-
CAS REGISTRY NUMBER : 53152-21-9
OTHER CAS REGISTRY NOS. : 64425-21-4
LAST UPDATED : 199212
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C29-H41-N-O4.Cl-H
MOLECULAR WEIGHT : 504.17
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Buprenorphine hydrochloride
* M-6029
* MR 56
* NIH 8805

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2857 ug/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
296,214,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Skin and Appendages - hair
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Blood - changes in spleen
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 62 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >600 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - ataxia
Blood - changes in spleen
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Liver - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Blood - changes in spleen
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 72 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >600 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - ataxia
Blood - changes in spleen
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 79 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 35,1351,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 35,1351,1984

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 35 mg/kg/5W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,486,1982

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 1350 ug/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - physical
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,532,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 300 ug/kg
SEX/DURATION : female 17-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,532,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 550 ug/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 13,509,1982

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
6,14-Ethenomorphinan-7-methanol,alpha-butyl-alpha,17-dimethyl-4,5-epoxy-3-hydroxy-6-methoxy-, (5-alpha,7-alpha(R))- 14521-97-2
6,14-Ethenomorphinan-7-methanol,alpha-butyl-alpha,17-dimethyl-4,5-epoxy-6-methoxy-,(5-alpha,7-alpha(R))- 61520-51-2
6,14-Ethenomorphinan-7-methanol,alpha-butyl-alpha,17-dimethyl-4,5-epoxy-6-methoxy-3-(2-phenylethoxy)-, (5-alpha,7-alpha(R))- 61520-44-3
6,14-Ethenomorphinan-7-methanol,alpha-butyl-alpha,17-dimethyl-4,5-epoxy-6-methoxy-3-(phenyl methoxy)-, (5-alpha,7-alpha(R))- 61520-41-0
6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-,(5-alpha,7-alpha-(S))- 52485-79-7
6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-,hydrochloride, (5-alpha,7-alpha(S))- 53152-21-9
Ethanone, 1,2-di-2-furanyl-2-hydroxy- 552-86-3
6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-4,5-epoxy-6-methoxy-alpha-methyl- alpha-(3-methylbutyl)-, hydrochloride 53056-01-2
6,14-Ethenomorphinan-7-methanol,18,19-dihydro-17-(cyclopropylmethyl)-alpha,alpha-dimethyl- 4,5-epoxy-3-hydroxy-6-methoxy-, hydrochloride,(5-alpha,7-alpha)- 16808-86-9
6,14-Ethenomorphinan-7-methanol,3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-(3-methyl- butyl)- (5-alpha,7-alpha(R))- 16180-33-9
6,14-Ethenomorphinan-7-methanol,3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-pentyl-, (5-alpha,7-alpha(R))- 16180-32-8
6,14-Ethenomorphinan-7-methanol,3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-(2-phenyl ethyl)-, (5-alpha,7-alpha(R))- 13965-63-4
6,14-Ethenomorphinan-7-methanol,3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-propyl-, (5-alpha,7-alpha(R))- 16180-26-0
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-3-hydroxy-6-methoxy-alpha- (3-methylbutyl)-, (5-alpha,7-alpha(R))- 14186-98-2
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-3-hydroxy-6-methoxy-alpha- pentyl-, (5-alpha,7-alpha(R))- 16530-40-8
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-3-hydroxy-6-methoxy-alpha- (2-phenylethyl)-, (5-alpha,7-alpha(R))- 14521-98-3
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-(3-methylbutyl)-,(5-alpha,7-al pha(R))- 61521-78-6
Ethanone,2-(4-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)-1-piperazinyl)-1-(2,4,6- trimethoxyphenyl)-,dihydrochloride 57218-08-3
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-(3-methylbutyl)-3-(1-oxopropoxy)-,(5-alpha,7-alpha(R))- 61521-77-5
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-(3-methylbutyl)-3-(2-phenylethoxy)-,(5-alpha,7-alpha(R))- 61520-45-4
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-(3-methylbutyl)-3-(phenylmethoxy)-,(5-alpha,7-alpha(R))- 61520-42-1
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-3-(1-oxopropoxy)- alpha-(2-phenylethyl)-, (5-alpha,7-alpha(R))- 61520-48-7
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-pentyl-,(5-alpha,7-alpha(R))- 26236-50-0
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-3-(2-phenylethoxy)-alpha-(2-phenylethyl)-,(5-alpha,7-alpha(R))- 61520-46-5
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-(2-phenylethyl)-, (5-alpha,7-alpha(R))- 26627-00-9
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-(2-phenylethyl)-3-(phenylmethoxy)-,(5-alpha,7-alpha(R))- 61520-43-2
6,14-Ethenomorphinan-7-methanol,alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-propyl-,(5-alpha,7-alpha(R))- 26626-23-3
3b,11-Etheno-3bH-naphth(2,1-e)isoindole-6-carboxylicacid, 1,2,3,3a,4,5,5a,6,7,8,9,9a,9b,10,11,11a-hexadecahydro-6,9a-dimethyl-1,3-dioxo-12-isopropyl-2-(piperidinomet hyl)- 67224-54-8
Ethanone, 1-(2,3-dihydro-5-benzofuranyl)-2-phenyl- 67224-54-8
1,4-Ethenopentalene,1,2,3,5,7,8-hexachloro-1,3a,4,5,6,6a-hexahydro-,(1-alpha,3a-alpha, 4-beta,5-alpha,6a-alpha)- 56534-02-2
4,8-Ethenopyrrolo(3',4'3,4)cyclobut(1,2-f)isoindole-2,6-diacetic acid,1,3,3a,3b,4,4a,5,7,7a,8,8a,8b-dodecahydro-alpha,alpha'-bis(2-methylpropyl) -1,3,5,7-tetraoxo- 122504-22-7
4,8-Ethenopyrrolo(3',4'3,4)cyclobut(1,2-f)isoindole-2,6-dihexanoic acid, 1,3,3a,3b,4,4a,5,7,7a,8,8a,8b-dodecahydro-1,3,5,7-tetraoxo- 38492-17-0
6,14-endo-Ethenotetrahydrooripavine,7-alpha-(1-hydroxy-1-methylbutyl)- 14521-96-1
6,14-endo-Ethenotetrahydrooripavine,7-alpha-(1-(R)-hydroxy-1-methylbutyl)-, hydrochloride 13764-49-3
Ether, allyl (2,2-bis(hydroxymethyl)butyl) 682-11-1
Ether, allyl methyl 682-11-1
Ether, allyl pentabromophenyl 3555-11-1
Ether, allyl 2,2,2-trifluoroethyl 1524-54-5
Ether, allyl vinyl 3917-15-5
Ethanone,2-((1-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)-3-azetidinyl)methyla mino)-1- phenyl-,dihydrochloride 69159-19-9
Ether, aryl polyoxyethylene 9041-09-2
Ether, benzyl isopentyl 122-73-6
Ether, benzyl thymyl 69455-01-2
Ether, bis(4-amino-3-chlorophenyl) 28434-86-8
Ether, bis(4-bromophenyl) 2050-47-7
Ether, bis(2-butoxyethyl) 112-73-2
Ether, bis(4-chlorobutyl) 6334-96-9
Ether, bis(2-(2-chloroethoxy)ethyl) 638-56-2
Ether, bis(1-chloroethyl) 6986-48-7
Ether, bis(2-chloroethyl) 111-44-4

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