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MSDS  : Fumaric acid
CAS  : 110-17-8
SYNONYMS  : * Allomaleic acid * Boletic acid * trans-Butenedioic acid * Butenedioic acid, (E)- * 1,2-Ethenedicarboxylic acid, trans- * trans-1,2-Ethylenedicarboxylic acid * 1,2-Ethylenedicarboxylic acid, (E) * Kyselina fumarova * Lichenic acid * NSC-2752 * U-1149 * USAF EK-P-583
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : LS9625000
CHEMICAL NAME : Fumaric acid
CAS REGISTRY NUMBER : 110-17-8
BEILSTEIN REFERENCE NO. : 0605763
REFERENCE : 4-02-00-02202 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C4-H4-O4
MOLECULAR WEIGHT : 116.08
WISWESSER LINE NOTATION : QV1U1VQ -T
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Allomaleic acid
* Boletic acid
* trans-Butenedioic acid
* Butenedioic acid, (E)-
* 1,2-Ethenedicarboxylic acid, trans-
* trans-1,2-Ethylenedicarboxylic acid
* 1,2-Ethylenedicarboxylic acid, (E)
* Kyselina fumarova
* Lichenic acid
* NSC-2752
* U-1149
* USAF EK-P-583

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,313,1986

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,313,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
42,417,1977

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 587 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Blood - hemorrhage
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 35,298,1946

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62,
1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year:
15,628,1923

** MUTATION DATA **

TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 40 mg/kg
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
Volume(issue)/page/year: 77,750,1986

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 33940
No. of Facilities: 2317 (estimated)
No. of Industries: 27
No. of Occupations: 44
No. of Employees: 30637 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 33940
No. of Facilities: 5692 (estimated)
No. of Industries: 40
No. of Occupations: 58
No. of Employees: 136448 (estimated)
No. of Female Employees: 48919 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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Fumaric acid, bis(2-chloroethyl) ester 5335-09-1
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Fumaric acid, dihexyl ester 19139-31-2
Fumaric acid, dihydrazide 3538-81-6
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Fumaric acid, diisobutyl ester 7283-69-4
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