*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LS9625000
CHEMICAL NAME : Fumaric acid
CAS REGISTRY NUMBER : 110-17-8
BEILSTEIN REFERENCE NO. : 0605763
REFERENCE : 4-02-00-02202 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C4-H4-O4
MOLECULAR WEIGHT : 116.08
WISWESSER LINE NOTATION : QV1U1VQ -T
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Allomaleic acid
* Boletic acid
* trans-Butenedioic acid
* Butenedioic acid, (E)-
* 1,2-Ethenedicarboxylic acid, trans-
* trans-1,2-Ethylenedicarboxylic acid
* 1,2-Ethylenedicarboxylic acid, (E)
* Kyselina fumarova
* Lichenic acid
* NSC-2752
* U-1149
* USAF EK-P-583
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,313,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,313,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
42,417,1977
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 587 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Blood - hemorrhage
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 35,298,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62,
1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year:
15,628,1923
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intravenous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 40 mg/kg
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
Volume(issue)/page/year: 77,750,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 33940
No. of Facilities: 2317 (estimated)
No. of Industries: 27
No. of Occupations: 44
No. of Employees: 30637 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 33940
No. of Facilities: 5692 (estimated)
No. of Industries: 40
No. of Occupations: 58
No. of Employees: 136448 (estimated)
No. of Female Employees: 48919 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
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Formamide, N-(1-adamantyl-1-ethyl)-
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Fuels, diesel, No. 2
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Fulvomycin A
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Fulvomycin A, sodium salt
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Fulvomycin B
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Fulvomycin B, sodium salt
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Fulvomycin C
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Fulvomycin C, sodium salt
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Fulvotomentosaside
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Formamide, N-(1-adamantyl-1-hexyl)-
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Fumaramic acid, N-(5-methyl-1,3,4-thiadiazol-2-yl)-
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Fumaramic acid, N-(4-phenyl-2-thiazolyl)-
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Fumaramic acid, N-(5-propyl-1,3,4-thiadiazol-2-yl)-,methyl ester
| 101468-17-1 |
Fumaria officinalis, alkaloidal extract
| 101468-17-1 |
Fumaria officinalis Linn., seed extractSUBSTANCE DEFINITION :Plant belonging to the family FumariaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 101468-17-1 |
Fumaria parviflora Lamk., extractSUBSTANCE DEFINITION :Plant belonging to the family FumariaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 101468-17-1 |
Fumaria vaillantii Loisel, alkaloidal fractionSUBSTANCE DEFINITION :Plant belonging to the family FumariaceaeREFERENCE :QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands)V.1-19, 1961-81. For publisher information, see IJCREE.
| 101468-17-1 |
Fumaric acid
| 110-17-8 |
Fumaric acid, chlorinated
| 110-17-8 |
Fumaric acid, compd. with 3-(2-aminoethyl)indol-5-ol,acetate (1:2:2)
| 110-17-8 |
Formamide, N-(2-adamantyl)-, hydrochloride
| 74525-97-6 |
Fumaric acid, (6-benzamido-m-anisidino)-, dimethylester
| 19271-17-1 |
Fumaric acid, bis(3-allyloxy-2-hydroxypropyl) ester
| 5975-73-5 |
Fumaric acid, bis(2-aminoethyl) ester,dihydrochloride
| 4126-70-9 |
Fumaric acid, bis(2-(2-chloroethoxy)ethyl) ester
| 63957-09-5 |
Fumaric acid, bis(2-chloroethyl) ester
| 5335-09-1 |
Fumaric acid, bis(2-ethylhexyl) ester
| 141-02-6 |
Fumaric acid, bis(p-methoxyphenyl) ester
| 31263-13-5 |
Fumaric acid, bis(2-naphthyl) ester
| 73839-82-4 |
Fumaric acid, alpha-butylbenzyl ester
| 97405-37-3 |
Fumaric acid, butyl 2,3-epoxypropyl ester
| 25876-07-7 |
Formamide, N-(1-adamantyl-1-propyl)-
| 101468-18-2 |
Fumaric acid, dibutyl ester
| 105-75-9 |
Fumaric acid, dihexyl ester
| 19139-31-2 |
Fumaric acid, dihydrazide
| 3538-81-6 |
Fumaric acid, dihydroxy-
| 133-38-0 |
Fumaric acid, dihydroxy-, mixed with1-deoxy-1-(methylamino)-D-glucitol
| 133-38-0 |
Fumaric acid, dihydroxy-, dimethyl ester
| 133-47-1 |
Fumaric acid, dihydroxy-, dimethyl ester, diacetate
| 130-84-7 |
Fumaric acid, diisobutyl ester
| 7283-69-4 |
Fumaric acid, diisopropyl ester
| 7283-70-7 |
Fumaric acid, disodium salt
| 17013-01-3 |
Formamide,N-(5-amino-2-((5-(1,3-dioxoisoindolin-2-yl)pentyl)oxy)benzyl)-
| 5819-82-9 |
Fumaric acid, 1,4-dithio-, S,S-diphenyl ester
| 73839-62-0 |
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