*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LQ8500000
CHEMICAL NAME : Formic acid, ethylidenemethylhydrazide
CAS REGISTRY NUMBER : 16568-02-8
OTHER CAS REGISTRY NOS. : 69349-96-8
BEILSTEIN REFERENCE NO. : 1922396
LAST UPDATED : 199612
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C4-H8-N2-O
MOLECULAR WEIGHT : 100.14
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Acetaldehyde-N-formyl-N-methylhydrazone
* Cetaldehyde methylformylhydrazone
* Acetaldehyde-N-methyl-N-formylhydrazone
* Ethylidene gyromitrin
* Gyromitrin
* Hydrazine carboxaldehyde, ethylidenemethyl-
* N-Methyl-N-formyl hydrazone of acetaldehyde
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - child
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MGLHAE Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und
Hygiene. (Eidgenoessiche Drucksachen und Materialzentrale, 3000 Bern,
Switzerland) V.1- 1910- Volume(issue)/page/year: 65,453,1974
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MGLHAE Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und
Hygiene. (Eidgenoessiche Drucksachen und Materialzentrale, 3000 Bern,
Switzerland) V.1- 1910- Volume(issue)/page/year: 65,453,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 320 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - food intake (animal)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 15,575,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 344 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,167,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
62,395,1975
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5200 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 39,884,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 28,559,1981
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,391,1987
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 31,163,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
JMTHBU Journal of the Medical Association of Thailand. (Businesss Mgr.,
Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7,
Thailand) V.1- 1918- Volume(issue)/page/year: 58,623,1975
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; TRP reversion
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Formhydroxamic acid
| 4312-87-2 |
Formic acid
| 64-18-6 |
Formic acid,1-benzyl-2-(4,6-dimethyl-3-pyridazinyl)hydrazide
| 17258-16-1 |
Formic acid, benzyl ester
| 104-57-4 |
Formic acid, 2,2-bis(2-chloroethyl)hydrazide
| 98069-43-3 |
Formic acid, butyl ester
| 592-84-7 |
Formic acid, 1-butylhydrazide
| 16120-70-0 |
Formic acid, cadmium salt
| 4464-23-7 |
Formic acid, calcium salt
| 544-17-2 |
Fobos M-2
| 78922-31-3 |
Formaldehyde, (5-nitro-2-pyridyl)hydrazone
| 28050-83-1 |
Formic acid, chloro-, allyl ester
| 2937-50-0 |
Formic acid, chloro-, 2-chloroethyl ester
| 627-11-2 |
Formic acid, chloro-, ethylene ester
| 124-05-0 |
Formic acid, chloro-, ethyl ester
| 541-41-3 |
Formic acid,4-(3-(2-chloroethyl)-3-nitrosoureido)cyclohexylester, (E)-
| 67227-29-6 |
Formic acid, chloro-, fluoren-9-ylmethyl ester
| 28920-43-6 |
Formic acid, chloro-, 2-fluoroethyl ester
| 462-27-1 |
Formic acid, chloro-, isopropyl ester
| 108-23-6 |
Formic acid, chloro-, 1-naphthyl ester
| 3759-61-3 |
Formic acid, chloro-, oxydiethylene ester
| 106-75-2 |
Formaldehyde, nitro-, p-tolylhydrazone
| 37703-97-2 |
Formic acid, chloro-, propyl ester
| 109-61-5 |
Formic acid, chlorothio-, S-methyl ester
| 18369-83-0 |
Formic acid, chlorothio-, S-propyl ester
| 13889-92-4 |
Formic acid, chloro-, trichloromethyl ester
| 503-38-8 |
Formic acid, chloro-, 2,4,6-trichlorophenyl ester
| 4511-19-7 |
Formic acid, cyano-, methyl ester
| 17640-15-2 |
Formic acid, compd. with cyclohexanamine (11)
| 34961-28-9 |
Formic acid,(((6,8-dibromo-3-(2-chlorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl) sulfonyl)-, methyl ester
| 108659-80-9 |
Formic acid,(((6,8-dibromo-3,4-dihydro-3-(2-methoxyphenyl)-4-oxo-2-quinazolinyl)methyl) sulfonyl)-, methyl ester
| 108659-75-2 |
Formic acid, compd. with1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9- one N-oxide (1:1)
| 64265-19-6 |
Formaldehyde, oxime
| 75-17-2 |
Formic acid, dithiobis(thio-, O,O-diethyl ester
| 502-55-6 |
Formic acid, dithiobis(thio-, O,O-dimethyl ester
| 1468-37-7 |
Formic acid, ethyl ester
| 109-94-4 |
Formic acid, 1-ethylhydrazide
| 74920-78-8 |
Formic acid, ethylidenemethylhydrazide
| 16568-02-8 |
Formic acid, 2-(4-(2-furyl)-2-thiazolyl)hydrazide
| 31873-81-1 |
Formic acid, heptyl ester
| 112-23-2 |
Formic acid, hexyl ester
| 629-33-4 |
Formic acid, hexylidenemethylhydrazide
| 57590-22-4 |
Formic acid, hydrazide
| 624-84-0 |
Formaldehyde, polymer with benzenamine
| 25214-70-4 |
Formic acid, hydrazodi-
| 628-36-4 |
Formic acid, indium(3+) salt
| 40521-21-9 |
Formic acid, isobutyl ester
| 542-55-2 |
Formic acid, isopropyl ester
| 625-55-8 |
Formic acid, methyl ester
| 107-31-3 |
Formic acid, methylhydrazide
| 758-17-8 |
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