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MSDS  : Formic acid, ethylidenemethylhydrazide
CAS  : 16568-02-8
SYNONYMS  : * Acetaldehyde-N-formyl-N-methylhydrazone * Cetaldehyde methylformylhydrazone * Acetaldehyde-N-methyl-N-formylhydrazone * Ethylidene gyromitrin * Gyromitrin * Hydrazine carboxaldehyde, ethylidenemethyl- * N-Methyl-N-formyl hydrazone of acetaldehyde
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : LQ8500000
CHEMICAL NAME : Formic acid, ethylidenemethylhydrazide
CAS REGISTRY NUMBER : 16568-02-8
OTHER CAS REGISTRY NOS. : 69349-96-8
BEILSTEIN REFERENCE NO. : 1922396
LAST UPDATED : 199612
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C4-H8-N2-O
MOLECULAR WEIGHT : 100.14
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Acetaldehyde-N-formyl-N-methylhydrazone
* Cetaldehyde methylformylhydrazone
* Acetaldehyde-N-methyl-N-formylhydrazone
* Ethylidene gyromitrin
* Gyromitrin
* Hydrazine carboxaldehyde, ethylidenemethyl-
* N-Methyl-N-formyl hydrazone of acetaldehyde

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - child
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MGLHAE Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und
Hygiene. (Eidgenoessiche Drucksachen und Materialzentrale, 3000 Bern,
Switzerland) V.1- 1910- Volume(issue)/page/year: 65,453,1974

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MGLHAE Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und
Hygiene. (Eidgenoessiche Drucksachen und Materialzentrale, 3000 Bern,
Switzerland) V.1- 1910- Volume(issue)/page/year: 65,453,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 320 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - food intake (animal)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 15,575,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 344 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,167,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
62,395,1975

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5200 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 39,884,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 28,559,1981

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,391,1987

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 31,163,1983

IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

TOXICOLOGY REVIEW
JMTHBU Journal of the Medical Association of Thailand. (Businesss Mgr.,
Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7,
Thailand) V.1- 1918- Volume(issue)/page/year: 58,623,1975

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; TRP reversion


*** END OF RECORD ***
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Formic acid, isopropyl ester 625-55-8
Formic acid, methyl ester 107-31-3
Formic acid, methylhydrazide 758-17-8

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