Search   
MSDS  : Guanidine, 1,3-diphenyl-
CAS  : 102-06-7
SYNONYMS  : * Accelerator D * Denax * Denax DPG * 1,3-Difenylguanid * Diphenylguanidine * N,N'-Diphenylguanidine * sym-Diphenylguanidine * 1,3-Diphenylguanidine * DPG accelerator * Dwufenyloguanidyna * Melaniline * NCI-C60924 * Nocceler D * USAF B-19 * USAF EK-1270 * Vulkacit D * Vulkacit D/C * Vulcafor DPG * Vulkazit
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : MF0875000
CHEMICAL NAME : Guanidine, 1,3-diphenyl-
CAS REGISTRY NUMBER : 102-06-7
LAST UPDATED : 199712
DATA ITEMS CITED : 29
MOLECULAR FORMULA : C13-H13-N3
MOLECULAR WEIGHT : 211.29
WISWESSER LINE NOTATION : MUYMR&MR
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Accelerator D
* Denax
* Denax DPG
* 1,3-Difenylguanid
* Diphenylguanidine
* N,N'-Diphenylguanidine
* sym-Diphenylguanidine
* 1,3-Diphenylguanidine
* DPG accelerator
* Dwufenyloguanidyna
* Melaniline
* NCI-C60924
* Nocceler D
* USAF B-19
* USAF EK-1270
* Vulkacit D
* Vulkacit D/C
* Vulcafor DPG
* Vulkazit

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 323 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3933

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068
Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 16,35,1965

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 323 mg/kg
TOXIC EFFECTS :
Blood - normocytic anemia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(7),35,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - ataxia
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 258 mg/kg
TOXIC EFFECTS :
Blood - normocytic anemia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(7),35,1978

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tetany
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 143,815,1949

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,974,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >794 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3933

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 246 mg/kg
TOXIC EFFECTS :
Blood - normocytic anemia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(7),35,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,974,1986

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tetany
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 143,815,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3808 mg/kg/17W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(7),35,1978

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 76 mg/kg
SEX/DURATION : female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 4(1),451,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 190 mg/kg
SEX/DURATION : female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 4(1),451,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 56 mg/kg
SEX/DURATION : male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 11,869,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 196 mg/kg
SEX/DURATION : male 49 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 11,869,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 140 mg/kg
SEX/DURATION : male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 11,869,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 224 mg/kg
SEX/DURATION : male 56 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 11,869,1983

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 360 ng/plate
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
Volume(issue)/page/year: 6(1-2),293,1985

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 33 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
7),1,1986

TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION : 36 ng/kg
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
Volume(issue)/page/year: 6(1-2),293,1985

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 27760
No. of Facilities: 326 (estimated)
No. of Industries: 10
No. of Occupations: 21
No. of Employees: 14344 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 27760
No. of Facilities: 874 (estimated)
No. of Industries: 14
No. of Occupations: 40
No. of Employees: 28146 (estimated)
No. of Female Employees: 4339 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9186;8EHQ-0892-9256

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Toxicity studies, RPT# TOX-42, October 1997


*** END OF RECORD ***
Search More   
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
3,5-Heptadienoic acid,7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(3Z,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 64775-52-6
3,5-Heptadienoic acid,7-(2-(4-(4-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(3,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 64775-52-6
2,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5E),2-beta(1E,3R*),3-alpha,5-alpha))- 64775-52-6
2,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 62524-94-1
3,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(3,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 73364-95-1
3,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(3E,5E),2-beta(1E,3R*),3-alpha,5-alpha))- 64812-77-7
3,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(3E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 64812-67-5
3,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(3Z,5E),2-beta(1E,3R*),3-alpha,5-alpha))- 64812-67-5
2,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1- butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 62559-74-4
3,5-Heptadienoic acid,7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1- butenyl)cyclopentyl)-, methyl ester,(1R-(1-alpha(3,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 62559-74-4
Guanidine, 1,3-diphenyl- 102-06-7
4,5-Heptadienoic acid,7-(3-hydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)-5-oxocyclopentyl)-, methyl ester,(1-alpha,2-beta(1E,3R*),3-alpha)- 73121-56-9
2,4-Heptadienoic acid,3-methoxy-7-(3,4-(methylenedioxy)phenyl)- 3384-27-8
1,6-Heptadien-4-ol 2883-45-6
1,6-Heptadien-4-ol, 4-ethyl- 52939-62-5
1,6-Heptadien-4-ol, 4-ethyl-, carbamate (ester) 52939-62-5
1,6-Heptadien-4-ol, 4-methyl- 25201-40-5
1,6-Heptadien-4-ol, 4-phenyl- 25201-40-5
1,6-Heptadien-4-ol, 4-phenyl-, carbamate (ester) 25201-40-5
3,5-Heptadien-2-one 3916-64-1
2,5-Heptadien-4-one, 2,6-dimethyl- 504-20-1
Guanidine, (2-(diphenylamino)ethyl)-, sulfate (21) 504-20-1
1,6-Heptadien-3-one,1-(2,6,6-trimethyl-2-cyclohexen-1-yl)- 79-78-7
2,4-Heptadione,7-chloro-6-(chlorodifluoromethyl)-7,7-difluoro-6-hydroxy- 6203-86-7
2,4-Heptadione,7-chloro-7,7-difluoro-6-hydroxy-6-(trifluoromethyl)- 101517-11-7
1,6-Heptadiyne 2396-63-6
2,4-Heptadiyne-1,7-diol, 1,1-diphenyl- 53019-27-5
HeptafunginSUBSTANCE DEFINITION :Isolated from Streptomyces longisporo lavendulae and Streptomyces achromolavendulaeREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,267,1980 53019-27-5
Heptamethylenediamine, N,N'-bis(o-chlorobenzyl)-,dihydrochloride 2056-22-6
Heptanal 111-71-7
Heptanal,2-(1,3-bis(trifluoromethyl)-2-hydroxy-2-propyl)-,thiosemicarbazone 111-71-7
Heptanal, 7-fluoro- 693-47-0
Guanidine, 1-(3-diphenylamino-2-hydroxypropyl)-,hemisulfate, dl- 67427-63-8
Heptanal,2-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)-, oxime 101517-12-8
Heptanal,2-(1-hydroxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl)- 34844-09-2
Heptanal, oxime 629-31-2
Heptanal, (5-nitro-2-pyridyl)hydrazone 28050-85-3
Heptanal, compd. with sulfurous acid monosodium salt(1:1) 6033-16-5
Heptanal, 3-thiosemicarbazone 5351-79-1
Heptanamide, 7-(p-(9-acridinylamino)phenyl)-,methanesulfonate 71798-50-0
Heptanamide,7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)- 1-hydroxy-2-oxoethyl)-,hydrochloride, (+)- 71798-50-0
Heptanamide,7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)- 1-hydroxy-2-oxoethyl)-3-hydroxy-,(S-(R*,R*))- 80902-43-8
Heptanamide,7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)- 1-hydroxy-2-oxoethyl)-, (+-)-,trihydrochloride 80902-43-8
Guanidine, 1,2-diphenyl-3-(2-mercaptoethyl)-,monohydrobromide 80902-43-8
Heptanamide,7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)- 1-hydroxy-2-oxoethyl)-,trihydrochloride, dihydrate 85468-01-5
Heptanamide,7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1- hydroxy-2-oxoethyl)-,trihydrochloride, dihydrate, (-)- 84937-45-1
Heptanamide,7-amino-N-(3-methyl-1-phenyl-1H-indol-2-yl)-,monohydrochloride 138349-49-2
Heptanamide,N-(2-((4-chloro-2-(2-chlorobenzoyl)phenyl)methylamino)-2-oxoethyl)- 65808-71-1
Heptanamide,N-(2,4-dibromo-6-((cyclohexylmethylamino)methyl)phenyl)-, monohydrochloride 71420-34-3
Heptanamide, 2-(diethylamino)-N-tert-pentyl-,hydrochloride 71420-34-3

Free MSDS Search ( Providing 250,000+ Material Properties )
Chemcas.com| Ads link:todaystock.net