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MSDS  : Guanidine, 2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-, hydrochloride
CAS  : 537-05-3
SYNONYMS  : * Acoin * Acoine * Acoin hydrochloride * Akoin hydrochlorid * N,N'-Bis(4-methoxyphenyl)-N''-(4-ethoxyphenyl)guanidine hydrochloride * alpha,gamma-Di-p-anisyl-beta-(ethoxyphenyl)guanidine hydrochloride * Dianisyl-monophenethylguanidine hydrochloride * Diparaanisyl-monophenethyl-guanidin-hydrochlorid * 2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride * Guanicaine * Guanidine, 2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)-, hydrochloride * Phenodianisyl * Phenodianisyl hydrochloride
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : MF2000000
CHEMICAL NAME : Guanidine,
2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-,
hydrochloride
CAS REGISTRY NUMBER : 537-05-3
LAST UPDATED : 199012
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C23-H25-N3-O3.Cl-H
MOLECULAR WEIGHT : 427.97
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Acoin
* Acoine
* Acoin hydrochloride
* Akoin hydrochlorid
* N,N'-Bis(4-methoxyphenyl)-N''-(4-ethoxyphenyl)guanidine hydrochloride
* alpha,gamma-Di-p-anisyl-beta-(ethoxyphenyl)guanidine hydrochloride
* Dianisyl-monophenethylguanidine hydrochloride
* Diparaanisyl-monophenethyl-guanidin-hydrochlorid
* 2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride
* Guanicaine
* Guanidine, 2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)-, hydrochloride
* Phenodianisyl
* Phenodianisyl hydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
REFERENCE :
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G.,
Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933
Volume(issue)/page/year: -,-,1933

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 53 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische
Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M.,
Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger.
Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983.
For publisher information, see 85KYAH. Volume(issue)/page/year:
10,1043,1983

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935

*** END OF RECORD ***
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