*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MT6434000
CHEMICAL NAME : Human recombinant tissue-type plasminogen activator,
SM-9527
LAST UPDATED : 199612
DATA ITEMS CITED : 6
COMPOUND DESCRIPTOR : Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* SM-9527
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 23,6513,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 23,6513,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : >136 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 23,6513,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 350 mg/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - normocytic anemia
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 23,6521,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 273 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 24,63,1990
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 130 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 25,117,1991
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Human anti-thromin III
| 75433-07-7 |
Human blood-coagulation factor XIII fraction, TG-731,freeze-dried
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Human chorionic gonadotropin, deglycosylated
| 75433-07-7 |
Hexylamine, N-2-propynyl-N,1,5-trimethyl-
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Human fibroblast interferon
| 7615-84-1 |
Human menopausal gonadotropin
| 61489-71-2 |
Human monoclonal antibody, TI-23
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Human platelet extract, ctap-III
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| 69344-77-0 |
Human recombinant leukocyte interferon
| 69344-77-0 |
Human recombinant tissue-type plasminogen activator,SM-9527
| 69344-77-0 |
Human recombinant tumor necrosis factor-alpha
| 94948-59-1 |
Human seminal plasma inhibin
| 94948-59-1 |
Human transforming growth factor beta
| 94948-59-1 |
Hexylamine, N,N,1,5-tetramethyl-, monohydrochloride
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Humboldtia brunonis Wall., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 94948-59-1 |
Humic acid, ammonium salt
| 94948-59-1 |
Humic acids
| 1415-93-6 |
Humic acids, hydrophilic macromolecular, chlorinated
| 1415-93-6 |
Humic acid, sodium salt
| 68131-04-4 |
Humidin
| 101670-43-3 |
Humulus lupulus, extract
| 101670-43-3 |
Hyacinth absolute
| 8023-94-7 |
Hyalodendrin II
| 101670-44-4 |
Hyaluronic acid, sodium salt
| 9067-32-7 |
Hexylamine, N,1,5-trimethyl-
| 503-00-4 |
Hyaluronicacid, sodium salt, high molecular weight
| 503-00-4 |
Hyamine 3500-NFSUBSTANCE DEFINITION :Quaternary ammonium compoundREFERENCE :FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,Willoughy, OH 44094) Volume(issue)/page/year: -,C167,1991
| 503-00-4 |
Hydantocidin
| 130607-26-0 |
Hydantoic acid, 1-phenyl-alpha-thio-
| 2215-20-5 |
Hydantoin
| 461-72-3 |
Hydantoin,1-((5-(p-acetamidophenyl)-2-furanyl)methyleneamino)-
| 41515-09-7 |
Hydantoin,1-((5-(p-acetamidophenyl)-2-furanyl)methyleneamino)-5-hydroxy-
| 64891-35-6 |
3-Hydantoinacetic acid,1-(5-nitrofurfurylideneamino)-, ethyl ester
| 1749-93-5 |
Hydantoin, 3-(acetoxymethyl)-5-ethyl-5-phenyl-
| 55251-14-4 |
Hydantoin, 1-acetyl-2-thio-
| 584-26-9 |
Hexylamine, N,1,5-trimethyl-, hydrochloride
| 63765-94-6 |
Hydantoin, 5-(p-(allyloxy)phenyl)-3,5-dimethyl-
| 63765-94-6 |
Hydantoin, 5-(p-(allyloxy)phenyl)-5-ethyl-
| 63765-94-6 |
Hydantoin, 5-(p-(allyloxy)phenyl)-5-methyl-
| 63765-94-6 |
Hydantoin, 5-(p-(allyloxy)phenyl)-5-propyl-
| 63765-94-6 |
Hydantoin, 1-allyl-5-phenyl-
| 37932-67-5 |
Hydantoin, 3-allyl-2-thioxo-
| 2010-16-4 |
Hydantoin, 3-amino-5,5-diphenyl-
| 1224-08-4 |
Hydantoin, 3-(2-aminoethyl)-2-thio-
| 87-54-7 |
Hydantoin,1-((5-(p-aminophenyl)-2-furanyl)methyleneamino)-
| 14663-28-6 |
Hydantoin,1-((5-(p-aminophenyl)-2-furanyl)methyleneamino)-5-hydroxy-
| 52130-28-6 |
Hexyl sulfoxide
| 2180-20-3 |
Hydantoin, 1-benzoyl-2-thio-
| 577-47-9 |
Hydantoin,5-benzyl-3-(3-(diethylamino)propyl)-2-thio-
| 86503-21-1 |
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