RTECS NUMBER : NI2922250
CHEMICAL NAME : 4H-Imidazo(1,5-a)(1,4)benzodiazepine,
8-chloro-6-(2-fluorophenyl)-1-methyl-, hydrochloride
CAS REGISTRY NUMBER : 59467-96-8
LAST UPDATED : 199706
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C18-H13-Cl-F-N3.Cl-H
MOLECULAR WEIGHT : 362.25
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
hydrochloride
* Hypnovel
* Midazolam hydrochloride
* Rocam
* Versed
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - child
DOSE/DURATION : 200 ug/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
Skin and Appendages - primary irritation (after topical exposure)
Immunological Including Allergic - other immediate (humoral): urticaria,
allergic rhinitis, serum sickness
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
293,822,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - child
DOSE/DURATION : 22 mg/kg/4D-I
TOXIC EFFECTS :
Liver - other changes
Blood - change in clotting factors
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
289,799,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 71 ug/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
Skin and Appendages - primary irritation (after topical exposure)
Immunological Including Allergic - other immediate (humoral): urticaria,
allergic rhinitis, serum sickness
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
293,822,1986
*** END OF RECORD ***
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