*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NR2392000
CHEMICAL NAME : Isoflavone, 4',5,7-trihydroxy-
CAS REGISTRY NUMBER : 446-72-0
BEILSTEIN REFERENCE NO. : 0263823
REFERENCE : 5-18-04-00594 (Beilstein Handbook Reference)
LAST UPDATED : 199801
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C15-H10-O5
MOLECULAR WEIGHT : 270.25
WISWESSER LINE NOTATION : T66 BO EVT&J CR DQ& IQ
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
* C.I. 75610
* Differenol A
* Genistein
* Genisteol
* Genisterin
* Prunetol
* Sophoricol
* 4',5,7-Trihydroxyisoflavone
* 5,7,4'-Trihydroxyisoflavone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 39,606,1986
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 125 mg/kg
SEX/DURATION : female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 208,60,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 625 mg/kg
SEX/DURATION : female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 208,60,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1680 mg/kg
SEX/DURATION : female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 13,94,1955
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 13200 mg/kg
SEX/DURATION : male 22 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 13,94,1955
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 18600 mg/kg
SEX/DURATION : female 31 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 13,94,1955
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
50,2618,1990
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 50 umol/L
REFERENCE :
CNCMET Cancer Communications. (Pergamon Press, Inc., Maxwell House,
Fairview Park, Elmsford, New York, 10523) V.1- 1989-
Volume(issue)/page/year: 2,271,1990
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 45 umol/L
REFERENCE :
CNCMET Cancer Communications. (Pergamon Press, Inc., Maxwell House,
Fairview Park, Elmsford, New York, 10523) V.1- 1989-
Volume(issue)/page/year: 2,271,1990
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 18 umol/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
35,605,1997
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 25 umol/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
35,605,1997
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Isocyanic acid, cyclohexyl ester
| 3173-53-3 |
Isocyanic acid, 2,3-dibromoallyl ester
| 101652-14-6 |
Isocyanic acid, 3,4-dichlorophenyl ester
| 102-36-3 |
Isocyanic acid, 3,3'-dimethoxy-4,4'-biphenylene ester
| 91-93-0 |
Isocyanic acid, ester with di-o-toluenemethane
| 139-25-3 |
Indolizine, 3-(3-(diethylamino)propyl)-2-methyl-
| 65548-79-0 |
Isocyanic acid, ethyl ester
| 109-90-0 |
Isocyanic acid, 4-fluorobutyl ester
| 353-16-2 |
Isocyanic acid, 2-fluoroethyl ester
| 505-12-4 |
Isocyanic acid, 3-fluoropropyl ester
| 407-99-8 |
Isocyanic acid, m-(fluorosulfonyl)phenyl ester
| 402-36-8 |
Isocyanic acid, 2,2,3,3,4,4,4-heptafluorobutyl ester
| 377-00-4 |
Isocyanic acid, hexahydro-4,7-methanoinden-2,8-yleneester
| 377-00-4 |
Isocyanic acid, hexamethylene ester, polymers
| 28182-81-2 |
Isocyanic acid, 4-(p-isocyanatobenzyl)-m-phenyleneester
| 51944-41-3 |
Isocyanic acid,p-isopropenyl-alpha,alpha-dimethylbenzyl ester
| 2889-58-9 |
Indolizine, 1-(2-(dimethylamino)ethyl)-2-phenyl-
| 13452-60-3 |
Isocyanic acid, methylenedi-4,1-cyclohexylene ester
| 5124-30-1 |
Isocyanic acid, methylenedi-p-phenylene ester
| 101-68-8 |
Isocyanic acid,methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester
| 4098-71-9 |
Isocyanic acid, methyl ester
| 624-83-9 |
Isocyanic acid, methyl-m-phenylene ester
| 26471-62-5 |
Isocyanic acid, 1,5-naphthylene ester
| 3173-72-6 |
Isocyanic acid, (p-(p-nitroanilino)phenyl)-
| 62967-27-5 |
Isocyanic acid, nitroiminodiethylenedi-
| 7046-61-9 |
Isocyanic acid, octadecyl ester
| 112-96-9 |
Isocyanic acid, m-phenylenedimethylene ester
| 3634-83-1 |
Indolizine, 1-((dimethylamino)methyl)-2-phenyl-
| 13452-58-9 |
Isocyanic acid, m-phenylene ester
| 123-61-5 |
Isocyanic acid, propyl ester
| 110-78-1 |
Isocyanic acid, triester with1,3,5-tris(6-hydroxyhexyl)biuret
| 4035-89-6 |
Isocyanic acid, (m-trifluoromethylphenyl) ester
| 329-01-1 |
Isocyanic acid, (alpha,alpha,alpha-trifluoro-o-tolyl)ester
| 2285-12-3 |
Isocyanic acid, p-xylylene ester
| 1014-98-8 |
Isodecyl alcohol
| 25339-17-7 |
Isoflavone, 8-(diethylaminomethyl)-7-hydroxy-,hydrochloride
| 67292-70-0 |
Isoflavone,8-(diethylaminomethyl)-7-hydroxy-2-methyl-,hydrochloride
| 67292-71-1 |
Isoflavone,7-(2-(dimethylamino)ethoxy)-4'-methoxy-2-methyl-
| 13004-41-6 |
Indolizine, 3-(3-(dimethylamino)propyl)-2-methyl-
| 65548-67-6 |
Isoflavone, 8-(dimethylaminomethyl)-7-hydroxy-,hydrochloride
| 67292-72-2 |
Isoflavone,8-(dimethylaminomethyl)-7-hydroxy-2-methyl-,hydrochloride
| 67292-77-7 |
Isoflavone, 7-hydroxy-2-methyl-8-(morpholinomethyl)-,hydrochloride
| 67292-73-3 |
Isoflavone, 7-hydroxy-2-methyl-8-(piperidinomethyl)-,hydrochloride
| 67292-74-4 |
Isoflavone, 7-hydroxy-8-(morpholinomethyl)-,hydrochloride
| 67292-75-5 |
Isoflavone, 7-hydroxy-8-(piperidinomethyl)-,hydrochloride
| 67292-76-6 |
Isoflavone, 4',5,7-trihydroxy-
| 446-72-0 |
Isoflavone, 4',5,7-trihydroxy-6-methoxy-
| 548-77-6 |
Isoflavonoid 1461
| 103842-84-8 |
Isoharringtonine
| 26833-86-3 |
Indolizine, 1-(3-(dimethylamino)propyl)-2-phenyl-
| 13452-59-0 |
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