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MSDS  : Isocyanic acid, 3,3'-dimethoxy-4,4'-biphenylene ester
CAS  : 91-93-0
SYNONYMS  : * 1,1'-Biphenyl, 4,4'-diisocyanato-3,3'-dimethoxy- * Dianisidine diisocyanate * 4,4'-Diisocyanato-3,3'-dimethoxy-1,1'-biphenyl * 3,3'-Dimethoxybenzidine-4,4'-diisocyanate * 3,3'-Dimethoxy-4,4'-biphenylene diisocyanate * 3,3'-Dimethoxy-4,4'-biphenylylene isocyanate * 3,3'-Dimethoxy-4,4'-biphenylylene isocyanic acid ester * NCI-C02175
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NQ8800000
CHEMICAL NAME : Isocyanic acid, 3,3'-dimethoxy-4,4'-biphenylene ester
CAS REGISTRY NUMBER : 91-93-0
BEILSTEIN REFERENCE NO. : 0928196
REFERENCE : 4-13-00-02837 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C16-H12-N2-O4
MOLECULAR WEIGHT : 296.30
WISWESSER LINE NOTATION : OCNR BO1 DR CO1 DNCO
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 1,1'-Biphenyl, 4,4'-diisocyanato-3,3'-dimethoxy-
* Dianisidine diisocyanate
* 4,4'-Diisocyanato-3,3'-dimethoxy-1,1'-biphenyl
* 3,3'-Dimethoxybenzidine-4,4'-diisocyanate
* 3,3'-Dimethoxy-4,4'-biphenylene diisocyanate
* 3,3'-Dimethoxy-4,4'-biphenylylene isocyanate
* 3,3'-Dimethoxy-4,4'-biphenylylene isocyanic acid ester
* NCI-C02175

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#02411

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 565 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-128,1979

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1200 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-128,1979

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 3300 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 81 ug/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 1,190,1981

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 39,279,1986

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 39,279,1986

IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2937
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 227 (estimated)

*** STATUS IN U.S. ***

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NCI Carcinogenesis Bioassay (feed);clear evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-128,79

NCI Carcinogenesis Bioassay (feed);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-128,79


*** END OF RECORD ***
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NAMECAS
Isocyanic acid, cyclohexyl ester 3173-53-3
Isocyanic acid, 2,3-dibromoallyl ester 101652-14-6
Isocyanic acid, 3,4-dichlorophenyl ester 102-36-3
Isocyanic acid, 3,3'-dimethoxy-4,4'-biphenylene ester 91-93-0
Isocyanic acid, ester with di-o-toluenemethane 139-25-3
Indolizine, 3-(3-(diethylamino)propyl)-2-methyl- 65548-79-0
Isocyanic acid, ethyl ester 109-90-0
Isocyanic acid, 4-fluorobutyl ester 353-16-2
Isocyanic acid, 2-fluoroethyl ester 505-12-4
Isocyanic acid, 3-fluoropropyl ester 407-99-8
Isocyanic acid, m-(fluorosulfonyl)phenyl ester 402-36-8
Isocyanic acid, 2,2,3,3,4,4,4-heptafluorobutyl ester 377-00-4
Isocyanic acid, hexahydro-4,7-methanoinden-2,8-yleneester 377-00-4
Isocyanic acid, hexamethylene ester, polymers 28182-81-2
Isocyanic acid, 4-(p-isocyanatobenzyl)-m-phenyleneester 51944-41-3
Isocyanic acid,p-isopropenyl-alpha,alpha-dimethylbenzyl ester 2889-58-9
Indolizine, 1-(2-(dimethylamino)ethyl)-2-phenyl- 13452-60-3
Isocyanic acid, methylenedi-4,1-cyclohexylene ester 5124-30-1
Isocyanic acid, methylenedi-p-phenylene ester 101-68-8
Isocyanic acid,methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester 4098-71-9
Isocyanic acid, methyl ester 624-83-9
Isocyanic acid, methyl-m-phenylene ester 26471-62-5
Isocyanic acid, 1,5-naphthylene ester 3173-72-6
Isocyanic acid, (p-(p-nitroanilino)phenyl)- 62967-27-5
Isocyanic acid, nitroiminodiethylenedi- 7046-61-9
Isocyanic acid, octadecyl ester 112-96-9
Isocyanic acid, m-phenylenedimethylene ester 3634-83-1
Indolizine, 1-((dimethylamino)methyl)-2-phenyl- 13452-58-9
Isocyanic acid, m-phenylene ester 123-61-5
Isocyanic acid, propyl ester 110-78-1
Isocyanic acid, triester with1,3,5-tris(6-hydroxyhexyl)biuret 4035-89-6
Isocyanic acid, (m-trifluoromethylphenyl) ester 329-01-1
Isocyanic acid, (alpha,alpha,alpha-trifluoro-o-tolyl)ester 2285-12-3
Isocyanic acid, p-xylylene ester 1014-98-8
Isodecyl alcohol 25339-17-7
Isoflavone, 8-(diethylaminomethyl)-7-hydroxy-,hydrochloride 67292-70-0
Isoflavone,8-(diethylaminomethyl)-7-hydroxy-2-methyl-,hydrochloride 67292-71-1
Isoflavone,7-(2-(dimethylamino)ethoxy)-4'-methoxy-2-methyl- 13004-41-6
Indolizine, 3-(3-(dimethylamino)propyl)-2-methyl- 65548-67-6
Isoflavone, 8-(dimethylaminomethyl)-7-hydroxy-,hydrochloride 67292-72-2
Isoflavone,8-(dimethylaminomethyl)-7-hydroxy-2-methyl-,hydrochloride 67292-77-7
Isoflavone, 7-hydroxy-2-methyl-8-(morpholinomethyl)-,hydrochloride 67292-73-3
Isoflavone, 7-hydroxy-2-methyl-8-(piperidinomethyl)-,hydrochloride 67292-74-4
Isoflavone, 7-hydroxy-8-(morpholinomethyl)-,hydrochloride 67292-75-5
Isoflavone, 7-hydroxy-8-(piperidinomethyl)-,hydrochloride 67292-76-6
Isoflavone, 4',5,7-trihydroxy- 446-72-0
Isoflavone, 4',5,7-trihydroxy-6-methoxy- 548-77-6
Isoflavonoid 1461 103842-84-8
Isoharringtonine 26833-86-3
Indolizine, 1-(3-(dimethylamino)propyl)-2-phenyl- 13452-59-0

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