*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OH6370000
CHEMICAL NAME : Leurosine
CAS REGISTRY NUMBER : 23360-92-1
OTHER CAS REGISTRY NOS. : 1362-18-1
BEILSTEIN REFERENCE NO. : 0079636
REFERENCE : 4-27-00-09622 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C46-H56-N4-O9
MOLECULAR WEIGHT : 809.06
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Amotin
* NSC-528004
* Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'-alpha,4'-alpha)-
* Vinleurosine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15200 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 18,667,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 105 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 18,667,1984
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 12 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg/30D-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 30 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Lupanine, 13-hydroxy-, monohydrochloride
| 6809-89-8 |
Lupanine, 17-hydroxy-, monohydrochloride
| 6810-18-0 |
Lupanine, monohydrochloride, hydrate
| 1025-39-4 |
Lupanine, 16-oxide, monohydrochloride
| 6810-17-9 |
Lupanine, 17-oxo-, hydrochloride
| 6853-92-5 |
2,6-Lupetidine
| 504-03-0 |
2,6-Lupetidine, hydrochloride
| 5072-45-7 |
Leurocristine sulfate (11)
| 2068-78-2 |
Lupinanium, 5-methyl-11-phthalimido-, methyl sulfate
| 2068-78-2 |
Lupinanium, 5-methyl-11-(3,4,5-trimethoxybenzamido)-,methyl sulfate
| 2068-78-2 |
Lupinine
| 486-70-4 |
Lupinine, acrylate (ester)
| 60537-74-8 |
Lupinus angustifolius, seed alkaloid mixture
| 60537-74-8 |
Lupinus sericeus Purch, alkaloid extract
| 60537-74-8 |
Lupulone
| 468-28-0 |
Lurosidine, sulfate (salt)
| 18556-44-0 |
Lursect
| 51609-52-0 |
Lustericin
| 51609-52-0 |
Leurosidine
| 15228-71-4 |
Lustromycin
| 105156-68-1 |
Luteinizing hormone
| 9002-67-9 |
Luteinizing hormone antiserum
| 9002-67-9 |
Luteinizing hormone, gonadographon releasing hormone
| 9002-67-9 |
Luteinizing hormone, ovine, beta-subunit
| 9002-67-9 |
Luteinizing hormone, rabbit antibovine serum
| 9002-67-9 |
Luteinizing hormone-releasing factor (pig), acetate(salt)
| 34973-08-5 |
Luteinizing hormone-releasing factor(pig),6-(3-(9-anthracenyl)-D-alanine)-, monoacetate (salt)
| 82318-04-5 |
Luteinizing hormone-releasing factor(pig),6-(3-(1-bromo-2-naphthalenyl)-D-alanine)-,monoacetate (salt)
| 82318-00-1 |
Luteinizing hormone-releasing factor(pig),6-(3-cyclohexyl-D-alanine)-, monoacetate (salt)
| 82317-94-0 |
Leurosine
| 23360-92-1 |
Luteinizing hormone-releasing factor(pig),6-(gamma-cyclohexyl-L-alpha- aminocyclohexanebutanoicacid)-, monoacetic (salt)
| 82318-05-6 |
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine)-6-D-tryptophan-10-glycine-, methyl ester, hydrochloride, hydrate(2:3:8)
| 71033-80-2 |
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine)-6-D-tryptophan-,hydrochloride, hydrate (2:3:8)
| 63889-45-2 |
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((phenylmethoxy)carbonyl)-L-leucine)-, hydrochloride, hydrate (2:3:6)
| 71033-95-9 |
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((phenylmethoxy)carbonyl)-O-(phenylmethyl)-L-serine)-6-D-phenylalanine-, hydrochloride, hydrate (2:3:8)
| 63929-61-3 |
Luteinizing hormone-releasing factor(pig),6-(3,5-dimethoxy-O-methyl-D-tyrosine)-, monoacetate(salt)
| 82317-93-9 |
Luteinizing hormone-releasing factor (pig),6-(O-1,1-dimethylethyl)-D-serene)-10- deglycinamide-,2-(aminocarbonyl)hydrazide
| 65807-02-5 |
Luteinizing hormone-releasing factor (pig),6-(O-(1,1-dimethylethyl)-D-serine)-10-deglycinamide-, 2-(aminocarboxyl)hydrazide,monoacetate
| 65807-02-5 |
Luteinizing hormone-releasing factor (pig),6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide, monoacetate (salt)
| 68630-75-1 |
Luteinizing hormone releasing factor (pig),9-(N-ethyl-L-prolinamide)-10-deglycinamide-,monoacetate (salt)
| 66002-66-2 |
Leucomycin V, 12,13-dihydro-12,13-epoxy-, 4(supB)-acetate 3-propanoate, (12S,13S)-
| 35942-57-5 |
Leutenizing hormone-releasing factor (pig),6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt)
| 74381-53-6 |
Luteinizing hormone-releasing factor (pig),6-(3-(2-naphthalenyl)-D-alanine)-
| 76932-56-4 |
Luteinizing hormone-releasing factor(pig),6-(3-(2-naphthalenyl)-D-alanine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt)
| 82318-07-8 |
Luteinizing hormone-releasing factor(pig),6-(3-(2-naphthalenyl)-D-alanine)-7-(N-methyl-L-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-,monoacetate (salt)
| 82375-04-0 |
Luteinizing hormone-releasing factor(pig),6-(3-(2-naphthalenyl)-D-alanine)-7-(N-methyl-L-leucine)-, monoacetate (salt)
| 82318-08-9 |
Luteinizing hormone-releasing factor(pig),6-(3-(1-naphthalenyl)-D-alanine)-, monoacetate (salt)
| 82317-96-2 |
Luteinizing hormone-releasing factor (pig),6-(3-(2-naphthalenyl)-D-alanine)-, monoacetate (salt)
| 76932-60-0 |
Luteinizing hormone-releasing factor(pig),3-(3-(1-naphthalenyl)-L-alanine)-6-(3-(2-naphthalenyl)-D-alanine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt)
| 82318-11-4 |
Luteinizing hormone-releasing factor(pig),6-(2,3,4,5,6-pentafluoro-D-phenylalanine)-,monoacetate (salt)
| 82317-95-1 |
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