Search   
MSDS  : Leurosine
CAS  : 23360-92-1
SYNONYMS  : * Amotin * NSC-528004 * Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'-alpha,4'-alpha)- * Vinleurosine
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : OH6370000
CHEMICAL NAME : Leurosine
CAS REGISTRY NUMBER : 23360-92-1
OTHER CAS REGISTRY NOS. : 1362-18-1
BEILSTEIN REFERENCE NO. : 0079636
REFERENCE : 4-27-00-09622 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C46-H56-N4-O9
MOLECULAR WEIGHT : 809.06
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Amotin
* NSC-528004
* Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'-alpha,4'-alpha)-
* Vinleurosine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15200 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 18,667,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 105 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 18,667,1984

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 12 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg/30D-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 30 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987

*** END OF RECORD ***
Search More   
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Lupanine, 13-hydroxy-, monohydrochloride 6809-89-8
Lupanine, 17-hydroxy-, monohydrochloride 6810-18-0
Lupanine, monohydrochloride, hydrate 1025-39-4
Lupanine, 16-oxide, monohydrochloride 6810-17-9
Lupanine, 17-oxo-, hydrochloride 6853-92-5
2,6-Lupetidine 504-03-0
2,6-Lupetidine, hydrochloride 5072-45-7
Leurocristine sulfate (11) 2068-78-2
Lupinanium, 5-methyl-11-phthalimido-, methyl sulfate 2068-78-2
Lupinanium, 5-methyl-11-(3,4,5-trimethoxybenzamido)-,methyl sulfate 2068-78-2
Lupinine 486-70-4
Lupinine, acrylate (ester) 60537-74-8
Lupinus angustifolius, seed alkaloid mixture 60537-74-8
Lupinus sericeus Purch, alkaloid extract 60537-74-8
Lupulone 468-28-0
Lurosidine, sulfate (salt) 18556-44-0
Lursect 51609-52-0
Lustericin 51609-52-0
Leurosidine 15228-71-4
Lustromycin 105156-68-1
Luteinizing hormone 9002-67-9
Luteinizing hormone antiserum 9002-67-9
Luteinizing hormone, gonadographon releasing hormone 9002-67-9
Luteinizing hormone, ovine, beta-subunit 9002-67-9
Luteinizing hormone, rabbit antibovine serum 9002-67-9
Luteinizing hormone-releasing factor (pig), acetate(salt) 34973-08-5
Luteinizing hormone-releasing factor(pig),6-(3-(9-anthracenyl)-D-alanine)-, monoacetate (salt) 82318-04-5
Luteinizing hormone-releasing factor(pig),6-(3-(1-bromo-2-naphthalenyl)-D-alanine)-,monoacetate (salt) 82318-00-1
Luteinizing hormone-releasing factor(pig),6-(3-cyclohexyl-D-alanine)-, monoacetate (salt) 82317-94-0
Leurosine 23360-92-1
Luteinizing hormone-releasing factor(pig),6-(gamma-cyclohexyl-L-alpha- aminocyclohexanebutanoicacid)-, monoacetic (salt) 82318-05-6
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine)-6-D-tryptophan-10-glycine-, methyl ester, hydrochloride, hydrate(2:3:8) 71033-80-2
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine)-6-D-tryptophan-,hydrochloride, hydrate (2:3:8) 63889-45-2
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((phenylmethoxy)carbonyl)-L-leucine)-, hydrochloride, hydrate (2:3:6) 71033-95-9
Luteinizing hormone-releasing factor(pig),1-de(5-oxo-L-proline)-2-(N-((phenylmethoxy)carbonyl)-O-(phenylmethyl)-L-serine)-6-D-phenylalanine-, hydrochloride, hydrate (2:3:8) 63929-61-3
Luteinizing hormone-releasing factor(pig),6-(3,5-dimethoxy-O-methyl-D-tyrosine)-, monoacetate(salt) 82317-93-9
Luteinizing hormone-releasing factor (pig),6-(O-1,1-dimethylethyl)-D-serene)-10- deglycinamide-,2-(aminocarbonyl)hydrazide 65807-02-5
Luteinizing hormone-releasing factor (pig),6-(O-(1,1-dimethylethyl)-D-serine)-10-deglycinamide-, 2-(aminocarboxyl)hydrazide,monoacetate 65807-02-5
Luteinizing hormone-releasing factor (pig),6-(O-(1,1-dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide, monoacetate (salt) 68630-75-1
Luteinizing hormone releasing factor (pig),9-(N-ethyl-L-prolinamide)-10-deglycinamide-,monoacetate (salt) 66002-66-2
Leucomycin V, 12,13-dihydro-12,13-epoxy-, 4(supB)-acetate 3-propanoate, (12S,13S)- 35942-57-5
Leutenizing hormone-releasing factor (pig),6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt) 74381-53-6
Luteinizing hormone-releasing factor (pig),6-(3-(2-naphthalenyl)-D-alanine)- 76932-56-4
Luteinizing hormone-releasing factor(pig),6-(3-(2-naphthalenyl)-D-alanine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt) 82318-07-8
Luteinizing hormone-releasing factor(pig),6-(3-(2-naphthalenyl)-D-alanine)-7-(N-methyl-L-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-,monoacetate (salt) 82375-04-0
Luteinizing hormone-releasing factor(pig),6-(3-(2-naphthalenyl)-D-alanine)-7-(N-methyl-L-leucine)-, monoacetate (salt) 82318-08-9
Luteinizing hormone-releasing factor(pig),6-(3-(1-naphthalenyl)-D-alanine)-, monoacetate (salt) 82317-96-2
Luteinizing hormone-releasing factor (pig),6-(3-(2-naphthalenyl)-D-alanine)-, monoacetate (salt) 76932-60-0
Luteinizing hormone-releasing factor(pig),3-(3-(1-naphthalenyl)-L-alanine)-6-(3-(2-naphthalenyl)-D-alanine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt) 82318-11-4
Luteinizing hormone-releasing factor(pig),6-(2,3,4,5,6-pentafluoro-D-phenylalanine)-,monoacetate (salt) 82317-95-1

Free MSDS Search ( Providing 250,000+ Material Properties )
Chemcas.com| Ads link:todaystock.net