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MSDS  : 4,7-Methanoindan, 1,4,5,6,7,8,8-heptachloro-2,3-epoxy-3a,4,7,7a-tetrahy dro-
CAS  : 1024-57-3
SYNONYMS  : * ENT 25,584 * Epoxyheptachlor * Heptachlor epoxide * HCE * Heptachlor epoxide * 1,4,5,6,7,8,8-Heptachloro-2,3-epoxy-2,3,3a,4,7,7a-hexahydro-4,7-methanoi ndene * 1,4,5,6,7,8,8-Heptachloro-2,3-epoxy-3a,4,7,7a-tetrahydro-4,7-methanoindan * 2,3,4,5,6,7,7-Heptachloro-1a,1b,5,5a,6,6a-hexahydro-2,5-methano-2H-inden o(1,2-b)oxirene * 2,5-Methano-2H-oxireno(a)indene, 2,3,4,5,6,7,7-heptachloro-1a,1b,5,5a,6,6a-hexahydro- * Velsicol 53-CS-17
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : PB9450000
CHEMICAL NAME : 4,7-Methanoindan,
1,4,5,6,7,8,8-heptachloro-2,3-epoxy-3a,4,7,7a-tetrahy
dro-
CAS REGISTRY NUMBER : 1024-57-3
OTHER CAS REGISTRY NOS. : 4067-30-5
24699-42-1
28044-82-8
66240-71-9
24717-72-4
LAST UPDATED : 199712
DATA ITEMS CITED : 25
MOLECULAR FORMULA : C10-H5-Cl7-O
MOLECULAR WEIGHT : 389.30
WISWESSER LINE NOTATION : T D3 C555 A EO JUTJ AG AG BG GG IG JG KG
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* ENT 25,584
* Epoxyheptachlor
* Heptachlor epoxide
* HCE
* Heptachlor epoxide
* 1,4,5,6,7,8,8-Heptachloro-2,3-epoxy-2,3,3a,4,7,7a-hexahydro-4,7-methanoi
ndene
* 1,4,5,6,7,8,8-Heptachloro-2,3-epoxy-3a,4,7,7a-tetrahydro-4,7-methanoindan
* 2,3,4,5,6,7,7-Heptachloro-1a,1b,5,5a,6,6a-hexahydro-2,5-methano-2H-inden
o(1,2-b)oxirene
* 2,5-Methano-2H-oxireno(a)indene,
2,3,4,5,6,7,7-heptachloro-1a,1b,5,5a,6,6a-hexahydro-
* Velsicol 53-CS-17

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(2),93,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,27,1966

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 107,266,1953

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 60,289,1992

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 144 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth &
Seventh Inter-American Conferences on Toxicology and Occupational Medicine,
Miami, FL," Miami, FL, J.L. Halos, 1968-70 Volume(issue)/page/year:
6,231,1968/1970

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cattle
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
52,1127,1959

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 580 mg/kg/69W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
38,163,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 876 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.44- 1976- Volume(issue)/page/year: 45,147,1977

** MUTATION DATA **

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,161,1977

*** REVIEWS ***

ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-TWA 0.05 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 20,129,1979

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 53,115,1991

IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 5,173,1974

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 20,129,1979

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 53,115,1991

IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 53,115,1991

TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978

*** STATUS IN U.S. ***

ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/194492/AS

EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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NAMECAS
7,14-Methano-2H,6H-dipyrido(1,2-a1',2'-e)(1,5)diazocine, dodecahydro-6-butyl-,(R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) 75714-73-7
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7,14-Methano-2H,6H-dipyrido(1,2-a1',2'-e)(1,5)diazocine, dodecahydro-6-pentyl-,(R-(R*,R*)-2,3-dihydroxybutanedioate (1:1) 75686-51-0
7,14-Methano-2H,6H-dipyrido(1,2-a1',2'-e)(1,5)diazocin-6-one, dodecahydro-, (7S-(7-alpha,7a-beta,14-alpha,14a-beta))- 82109-83-9
7,14-Methano-2H,6H-dipyrido(1,2-a1',2'-e)(1,5)diazocin-6-one, dodecahydro-, monohydrochloride,(7R-(7-alpha,7a-alpha,14-alpha,14a-beta))- 40136-09-2
Methane, fluorotrichloro- with nitromethane(99.7:0.3)SUBSTANCE DEFINITION :Contains 0.3% nitromethane in addition to freon-11REFERENCE :TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,Japan) V.1- 1954- 40136-09-2
7,14-Methano-4H,6H-dipyrido(1,2-a1',2'-e)(1,5)diazocin-4-one, dodecahydro-, monohydrochloride,(7S-(7-alpha,7a-beta,14-alpha,14a-alpha))- 40136-09-2
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5,11-Methanofuro(3,4-d)(3)benzoxonin-1,12(3H,5H)-dione, 6,6a,7,8,9,10,10a,11-octahydro-6,6a-dihydroxy-3,11,13-trimethyl-,(3R-(3R*,5R*,6S*,6ar*,10ar*,11S*,13R*))- 166403-10-7
1,24-Methano-1H,9H,15H-furo(3',4'10,11)(1,7)dioxacyclotetradecino(4,3-e)p yrano(2,3-i)(4)benzoxecin-6,13,15,18(3ah)-tetrone,4,5,7a,8,16,17,20,20a,24,25,26,26a-dodecahydro-8,26-dihydroxy-22,25-dimethyl-5-methoxy- 99820-21-0
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8,12-Methano-2H-furo(3,2-g)pyrano(2,3-a)xanthene-10a(11H)-crotonic acid, 8,9,12,14-tetrahydro-5-hydroxy-alpha,2,9,9-tetramethyl-6-(3-methyl-2-butenyl)-2-(4-m ethyl-3- pentenyl)-11,14-dioxo- 6129-34-6
2,5-Methanoindan-4-amine, hexahydro-N-benzyl-,hydrochloride 59177-71-8
2,5-Methanoindan-4-amine,hexahydro-4-(p-chlorobenzyl)-, hydrochloride 67293-83-8
2,5-Methanoindan-4-amine, hexahydro-, hydrochloride 59177-69-4
Methane, fluorotrinitro- 1840-42-2
2,5-Methanoindan-4-amine,hexahydro-4-(2-hydroxyethyl)amino-, hydrochloride 59177-73-0
2,5-Methanoindan-4-amine, hexahydro-N-methyl-,hydrochloride 59177-70-7
2,5-Methanoindan-4-amine, hexahydro-4-phenethyl-,hydrochloride 67293-84-9
4,7-Metanoindan-2,5-bis(methylamine),hexahydro-N,N'-dicyclohexyl-, dihydrochloride 63905-06-6
4,7-Methanoindan, 1,25,6-diepoxyhexahydro-, mixedisomersSUBSTANCE DEFINITION :Mixture of 70% exo isomers, 30% endo isomersREFERENCE :AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 WolfLedges Pkwy., Akron, OH 44311) V.19- 1958- 63905-06-6
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4,7-Methanoindan,1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- 2589-15-3
4,7-Methanoindan, hexahydro-, exo- 2825-82-3
4,7-Methanoindan, hexahydro-1,8-diamino- 6818-18-4
4,7-Methanoindan,3a,4,5,6,7,7a-hexahydro-1,2:5,6-diepoxy- 81-21-0
Methanehydrazonamide,N'-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-N,N-dimethyl- 56364-22-8
4,7-Methanoindan,3a,4,5,6,7,7a-hexahydro-1,2:5,6-diepoxy-, endo- 56364-22-8
4,7-Methanoindan, hexahydro-2-hydroxymethyl- 64644-36-6
2,5-Methanoindan-4-methylamine, hexahydro-N-benzyl-,maleate 59177-78-5
2,5-Methanoindan-4-methylamine,hexahydro-N,N-dimethyl-4-hydroxy-, hydrochloride,hydrate (3:3:1) 67293-85-0
2,5-Methanoindan-4-methylamine,hexahydro-4-hydroxy-N-methyl-, maleate 59177-79-6
2,5-Methanoindan-4-methylamine, hexahydro-N-methyl-,maleate 59177-76-3
4,7-Methanoindan,1,2,4,5,6,7,8,8-octachloro-2,3-epoxy-3a,4,7,7a-tetrahydro-, exo,endo- 27304-13-8
4,7-Methanoindan,1-alpha,2-alpha,4-beta,5,6,7-beta,8,8-octachloro-3a-alpha,4,7,7a-alpha- tetrahydro- 5103-71-9
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4,7-Methanoindan,2,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-,stereoisomer 5566-34-7
Methane, iodo- 74-88-4
4,7-Methanoindan,1,2,3,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-, (Z)mixed with E-1,2,3,5,6,7,8,8-octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane (3:1) 74-88-4
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4,7-Methanoindan-1-ol,3a,4,7,7a-tetrahydro-2,3-epoxy-4,5,6,7,8,8-hexachloro- 24009-06-1
4,7-Methanoindan-5(4H)-one, tetrahydro- 13380-94-4
4,7-Methanoindan,3a,4,7,7a-tetrahydro-1,2-epoxy-4,5,6,7,8,8-hexachloro- 6058-23-7
4,7-Methanoindan,3a-alpha,4,7,7a-alpha-tetrahydro-2-alpha,4-beta,5,6,7-beta,8,8-heptachloro- 14168-01-5
4,7-Methanoindan,3a-beta,4,7,7a-beta-tetrahydro-1-beta,2-alpha,4-alpha,5,6,7-alpha,8,8- octachloro- 5103-74-2
4,7-Methano-1H-inden-5-amine,octahydro-N-(cyclopropylmethyl)-, hydrochloride,(3a-alpha,4- beta,5-alpha,7-beta,7a-alpha)- 73336-07-9
4,7-Methanoindene 209-96-1
4,7-Methanoindene,1-bromo-4,5,6,7,8,8-hexachloro-3a,4,7,7a-tetrahydro- 3186-23-0
Methane, iodo-, pyrolyzate 3186-23-0

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