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MSDS  : Methane, chlorofluoro-
CAS  : 593-70-4
SYNONYMS  : * CFC 31 * Chlorofluoromethane * FC 31 * Freon 31 * G 31 * Genetron 31 * Khladon 31 * Methylene chloride fluoride * Monochloromonofluoromethane * R 31 * R 31 (Refrigerant)
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : PA6408000
CHEMICAL NAME : Methane, chlorofluoro-
CAS REGISTRY NUMBER : 593-70-4
BEILSTEIN REFERENCE NO. : 1730796
REFERENCE : 4-01-00-00032 (Beilstein Handbook Reference)
LAST UPDATED : 199801
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C-H2-Cl-F
MOLECULAR WEIGHT : 68.48
WISWESSER LINE NOTATION : G1F
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* CFC 31
* Chlorofluoromethane
* FC 31
* Freon 31
* G 31
* Genetron 31
* Khladon 31
* Methylene chloride fluoride
* Monochloromonofluoromethane
* R 31
* R 31 (Refrigerant)

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12635 mg/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),34,1996

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 10000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
48,A109,1979

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10000 ppm/6H/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Endocrine - other changes
Blood - changes in spleen
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571266

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 78 gm/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
72,15,1984

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,277,1983

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 100 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
72,15,1984

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 pph
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 25,91,1982

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 41,229,1986

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 41,229,1986

IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-GERMANY;Carcinogen JAN 1993

OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993

OEL-SWITZERLAND;Carcinogen JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3008
No. of Facilities: 262 (estimated)
No. of Industries: 5
No. of Occupations: 5
No. of Employees: 2705 (estimated)
No. of Female Employees: 159 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Methane, tribromo- 75-25-2
Methanetricarbonitrile, sodium salt 75-25-2
Methane, trichlorofluoro- 75-69-4
Methane, trichloronitro- 76-06-2
Methane, trichloronitroso- 3711-49-7
Methane, chlorodifluoro- 75-45-6
Methane, trifluoro- 75-46-7
Methane, trifluoroiodo- 2314-97-8
Methane, triiodo- 75-47-8
Methane, trinitro- 517-25-9
Methane, tris(4-aminophenyl)- 548-61-8
Methane, tris(propoxymethyl)nitro- 63869-37-4
Methanimidamide,N'-(8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)-N,N-dime thyl-,(1aS-(1a-alpha,8-alpha,8a-alpha,8b-alpha))- 105551-80-2
Methanimidamide, N,N'-bis(1,3-benzodioxol-5-yl)- 75859-60-8
Methanimidamide,N,N-bis(2-hydroxyethyl)-N'-(5-((2,6-dichlorophenyl)methyl)- 1,2,4-oxadiazol-3-yl)-, hydrochloride 70925-94-9
Methanimidamide, N,N'-bis(2-methoxyphenyl)- 68012-05-5
Methane, chlorodinitro- 921-13-1
Methanimidamide, N,N'-bis(5-methyl-3-isoxazolyl)- 75859-61-9
Methanimidamide, N,N'-bis(1-methyl-2-phenylethyl)- 61945-58-2
Methanimidamide,N,N'-bis(1-methyl-2-phenylethyl)-N-methyl- 61945-55-9
Methanimidamide, N,N'-bis(4-(1-oxopropoxy)phenyl)- 75867-01-5
Methanimidamide, N,N'-bis(2-phenylethyl)-, hydrate 2303-90-4
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Methanimidamide,N'-(5-((2-chloro-6-fluorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl- 70926-10-2
Methanimidamide,N'-(5-chloro-4-formyl-1-phenyl-1H-pyrazol-3-yl)-N,N-dimethyl- 62208-78-0
Methanimidamide, N'-cyano-N,N-dimethyl- 39687-97-3
Methanimidamide,N'-(2-cyano-4-oxo-3(4H)-quinazolinyl)-N,N-dimethyl- 64843-08-9
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Methanimidamide,N'-(5-((2,6-dichlorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl-, hydrochloride 70926-03-3
Methanimidamide,N'-(1,6-dihydro-6-oxo-2-pyridinyl)-N,N-dipropyl- 111757-17-6
Methanimidamide,N'-(2-(3,4-dimethoxyphenyl)ethyl)-N,N-dimethyl-,phosphate (1:1) 61945-50-4
Methanimidamide,N,N-dimethyl-N'-(5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)- 131929-02-7
Methanimidamide,N,N-dimethyl-N'-(1-methyl-2-phenylethyl)-, phosphate(1:1) 61945-48-0
Methanimidamide,N,N-dimethyl-N'-(3-oxo-5-phenyl-1-cyclohexen-1-yl)- 131929-03-8
Methanimidamide,N,N-dimethyl-N'-(2-(2-oxo-1-pyrrolidinyl)ethyl)-,dihydrochloride 92884-75-8
Methanimidamide, N,N-dimethyl-N'-(2-phenylethyl)-,phosphate (1:1) 92884-75-8
Methanimidic acid,N-((2-(cyanoimino)-1-pyrrolidinyl)acetyl)-2-(2,4-dinitrophenyl)hydrazide 159383-33-2
Methanimidic acid, N-((2-oxo-1-pyrrolidinyl)acetyl)-,2-(4-nitrophenyl)hydrazide 95356-56-2
Methane, chlorofluoro- 593-70-4
4a,8a-(Methaniminomethano)naphthalene,10-(cyclopropylmethyl)-1,4,5,8-tetrahydro-,hydrochloride 17713-06-3
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-, hydrochloride 17730-84-6
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-10-methyl-, hydrochloride 17713-05-2
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-, hydrochloride 17730-83-5
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-10-methyl-, hydrochloride 17730-63-1
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Methane, chlorotrifluoro- 75-72-9

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