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MSDS   | : | Methanesulfonic acid,
2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester
| CAS   | : | 61866-12-4 | SYNONYMS   | : | * 2-(3-(2-Chlorathyl)-3-nitrosoureido)athylmethansulfonat
* 2-(3-(2-Chloroethyl)3-nitrosoureido)ethyl methane sulfonate
* Cnuems
* Ethylmethanesulfonato-cnu
* NSC-294896
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PB1800000
CHEMICAL NAME : Methanesulfonic acid,
2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester
CAS REGISTRY NUMBER : 61866-12-4
LAST UPDATED : 198806
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C5-H10-Cl-N3-O5-S
MOLECULAR WEIGHT : 259.69
WISWESSER LINE NOTATION : WS1&O1MVNNO&2G
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 2-(3-(2-Chlorathyl)-3-nitrosoureido)athylmethansulfonat
* 2-(3-(2-Chloroethyl)3-nitrosoureido)ethyl methane sulfonate
* Cnuems
* Ethylmethanesulfonato-cnu
* NSC-294896
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 23 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
VDGIA2 Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin. (J.F.
Bergmann Verlag, Agnes-Bernauer-Platz 8, D-8000 Munich 21, Fed. Rep. Ger.)
V.33-52, 1921-40; V.54- 1948- Volume(issue)/page/year: 85,1293,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13800 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Gastrointestinal - ulceration or bleeding from stomach
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21-
1967- Volume(issue)/page/year: 37,177,1980
** MUTATION DATA **
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 500 umol/L/16H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Methane, bromochlorodifluoro-, pyrolyzate
| 54301-15-4 |
Methanesulfon-m-anisidide,4'-(3-(methylamino)-9-acridinylamino)-
| 66147-74-8 |
Methanesulfonic acid
| 75-75-2 |
Methanesulfonic acid, acetyl-
| 75-75-2 |
Methanesulfonic acid, allyl ester
| 6728-21-8 |
Methanesulfonic acid, (antipyrinylamino)-, monosodiumsalt
| 129-89-5 |
Methanesulfonic acid, (antipyrinylmethylamino)-,monosodium salt
| 68-89-3 |
Methanesulfonic acid, (antipyrinylmethylamino)-,sodium salt, monohydrate
| 5907-38-0 |
Methanesulfonic acid, (antipyrinylmethylamino)-,sodium salt, mixed with sodium nitrite (1:1)
| 5907-38-0 |
Methanesulfonic acid,(arsenobis((6-hydroxy-m-phenylene)imino))di-,disodium salt
| 618-82-6 |
Methanesulfonic acid, (3-arsenoso-6-hydroxyanilino)-,sodium salt
| 618-82-6 |
Methane, bromochlorodinitro-
| 33829-48-0 |
Methanesulfonic acid,1-(p-((5-benzamidopentyl)oxy)anilino)-, sodium salt
| 33829-48-0 |
Methanesulfonic acid,(3-(bis((carbamoylmethyl)thio)arsino)-5-(2-hydroxyethoxy)anilino)-, sodium salt
| 33829-48-0 |
Methanesulfonic acid, 1-(p-butoxyanilino)-, sodiumsalt
| 33829-48-0 |
Methanesulfonic acid, 1-(p-butoxy-N-methylanilino)-,sodium salt
| 33829-48-0 |
Methanesulfonic acid,(p-((p-butoxyphenyl)sulfonyl)anilino)-, sodium salt,dihydrate
| 33829-48-0 |
Methanesulfonic acid, 1-((6-butoxy-3-pyridyl)amino)-,sodium salt
| 33829-48-0 |
Methanesulfonic acid, butyl ester
| 1912-32-9 |
Methanesulfonic acid, chloro-, ethyl ester
| 16764-27-5 |
Methanesulfonic acid,2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester
| 61866-12-4 |
Methanesulfonic acid,((3-cyclohexyl-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl) amino)-, sodium salt
| 61866-12-4 |
Methane, bromodichloro-
| 75-27-4 |
Methanesulfonic acid,((3-cyclohexyl-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl) methylamino)-, sodium salt
| 75-27-4 |
Methanesulfonic acid,((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) methylamino)-, sodium salt, mixt. withN-(1-methylethyl)-4,4-diphenyl cyclohexanaminehydrochloride
| 59915-31-0 |
Methanesulfonic acid,(3-(dihydroxyarsino)-6-(2-hydroxyethoxy)anilino)-,sodium salt
| 59915-31-0 |
Methanesulfonic acid, diiodo-, sodium salt
| 124-88-9 |
Methanesulfonic acid, 3-(dimethylamino)propyl ester,hydrochloride
| 52413-48-6 |
Methanesulfonic acid,((2,3-dimethyl-1-phenyl-5-oxo-3-pyrazolin-4-yl)methylamino)-, magnesium salt
| 6150-97-6 |
Methanesulfonic acid, (ethylenebis(methylimino))bis-,disodium salt
| 6150-97-6 |
Methanesulfonic acid, (ethylenedinitrilo)tetra-,tetrasodium salt
| 13046-10-1 |
Methanesulfonic acid, ethyl ester
| 62-50-0 |
Methanesulfonic acid, 4-fluorobutyl ester
| 592-61-0 |
Methane, bromodifluoro-
| 1511-62-2 |
Methanesulfonic acid, 2-fluoroethyl ester
| 461-31-4 |
Methanesulfonic acid, 6-fluorohexyl ester
| 352-95-4 |
Methanesulfonic acid, 5-fluoroheptyl ester
| 352-95-4 |
Methanesulfonic acid, 3-fluoropropyl ester
| 352-95-4 |
Methanesulfonic acid, hydroxy-, sodium salt
| 870-72-4 |
Methanesulfonic acid, iodo-, sodium salt
| 126-31-8 |
Methanesulfonic acid, isopropyl ester
| 926-06-7 |
Methanesulfonic acid, methoxymethyl ester
| 25289-73-0 |
Methanesulfonic acid, methyl ester
| 66-27-3 |
Methanesulfonic acid,(1-methyl-2-phenethyl)hydrazino-
| 3583-81-1 |
Methane, bromodinitro-
| 996-67-8 |
Methanesulfonic acid, 1-methylpropyl ester
| 16156-54-0 |
Methanesulfonic acid, 1-methylpropyl ester, (+-)-
| 119943-51-0 |
Methanesulfonic acid, 1-methylpropyl ester, (R)-
| 66194-68-1 |
Methanesulfonic acid, 1-methylpropyl ester, (S)-
| 50599-13-8 |
Methanesulfonic acid, (methylsulfonyl)-, 2-bromoethylester
| 88343-74-2 |
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