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MSDS  : Methane, bromodichloro-
CAS  : 75-27-4
SYNONYMS  : * BDCM * Bromodichloromethane * Dichlorobromomethane * Dichloromonobromomethane * Monobromodichloromethane * NCI-C55243
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : PA5310000
CHEMICAL NAME : Methane, bromodichloro-
CAS REGISTRY NUMBER : 75-27-4
BEILSTEIN REFERENCE NO. : 1697005
REFERENCE : 4-01-00-00076 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 37
MOLECULAR FORMULA : C-H-Br-Cl2
MOLECULAR WEIGHT : 163.83
WISWESSER LINE NOTATION : GYGE
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* BDCM
* Bromodichloromethane
* Dichlorobromomethane
* Dichloromonobromomethane
* Monobromodichloromethane
* NCI-C55243

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 430 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Liver - other changes
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
Liver - fatty liver degeneration
Blood - hemorrhage
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
44,213,1978

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 750 mg/kg/5D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 94,3,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5670 mg/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,119,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9828 mg/kg/9W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 50(4),80,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20075 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - fatty liver degeneration
Liver - other changes
Liver - changes in liver weight
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,51,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3500 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 46,117,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg/5D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 94,3,1994

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25500 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25500 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 51 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 38250 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-321,1987

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 750 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
40,30,1997

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 mg/plate
REFERENCE :
DHEFDK HEW Publication (FDA. United States). (Washington, DC) ?-1979(?).
For publisher information, see HPFSDS. Volume(issue)/page/year:
FDA-78-1046,1978

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 13,205,1987

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 400 umol/L
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 32,72,1983

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 164 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 242,111,1990

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Leukocyte
DOSE/DURATION : 200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,241,1993

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 180 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
11,91,1988

TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg/4D (Intermittent)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 32,72,1983

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 180 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
11,91,1988

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 13,205,1987

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,179,1991

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,179,1991

IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,179,1991

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5772
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 3266 (estimated)
No. of Female Employees: 502 (estimated)

*** STATUS IN U.S. ***

ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/167461/AS

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NTP Carcinogenesis Studies (gavage);clear evidence:rat,mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-321,87

NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen

NTP Carcinogenesis studies; selected, October 1997


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Methane, bromochlorodifluoro-, pyrolyzate 54301-15-4
Methanesulfon-m-anisidide,4'-(3-(methylamino)-9-acridinylamino)- 66147-74-8
Methanesulfonic acid 75-75-2
Methanesulfonic acid, acetyl- 75-75-2
Methanesulfonic acid, allyl ester 6728-21-8
Methanesulfonic acid, (antipyrinylamino)-, monosodiumsalt 129-89-5
Methanesulfonic acid, (antipyrinylmethylamino)-,monosodium salt 68-89-3
Methanesulfonic acid, (antipyrinylmethylamino)-,sodium salt, monohydrate 5907-38-0
Methanesulfonic acid, (antipyrinylmethylamino)-,sodium salt, mixed with sodium nitrite (1:1) 5907-38-0
Methanesulfonic acid,(arsenobis((6-hydroxy-m-phenylene)imino))di-,disodium salt 618-82-6
Methanesulfonic acid, (3-arsenoso-6-hydroxyanilino)-,sodium salt 618-82-6
Methane, bromochlorodinitro- 33829-48-0
Methanesulfonic acid,1-(p-((5-benzamidopentyl)oxy)anilino)-, sodium salt 33829-48-0
Methanesulfonic acid,(3-(bis((carbamoylmethyl)thio)arsino)-5-(2-hydroxyethoxy)anilino)-, sodium salt 33829-48-0
Methanesulfonic acid, 1-(p-butoxyanilino)-, sodiumsalt 33829-48-0
Methanesulfonic acid, 1-(p-butoxy-N-methylanilino)-,sodium salt 33829-48-0
Methanesulfonic acid,(p-((p-butoxyphenyl)sulfonyl)anilino)-, sodium salt,dihydrate 33829-48-0
Methanesulfonic acid, 1-((6-butoxy-3-pyridyl)amino)-,sodium salt 33829-48-0
Methanesulfonic acid, butyl ester 1912-32-9
Methanesulfonic acid, chloro-, ethyl ester 16764-27-5
Methanesulfonic acid,2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester 61866-12-4
Methanesulfonic acid,((3-cyclohexyl-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl) amino)-, sodium salt 61866-12-4
Methane, bromodichloro- 75-27-4
Methanesulfonic acid,((3-cyclohexyl-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl) methylamino)-, sodium salt 75-27-4
Methanesulfonic acid,((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) methylamino)-, sodium salt, mixt. withN-(1-methylethyl)-4,4-diphenyl cyclohexanaminehydrochloride 59915-31-0
Methanesulfonic acid,(3-(dihydroxyarsino)-6-(2-hydroxyethoxy)anilino)-,sodium salt 59915-31-0
Methanesulfonic acid, diiodo-, sodium salt 124-88-9
Methanesulfonic acid, 3-(dimethylamino)propyl ester,hydrochloride 52413-48-6
Methanesulfonic acid,((2,3-dimethyl-1-phenyl-5-oxo-3-pyrazolin-4-yl)methylamino)-, magnesium salt 6150-97-6
Methanesulfonic acid, (ethylenebis(methylimino))bis-,disodium salt 6150-97-6
Methanesulfonic acid, (ethylenedinitrilo)tetra-,tetrasodium salt 13046-10-1
Methanesulfonic acid, ethyl ester 62-50-0
Methanesulfonic acid, 4-fluorobutyl ester 592-61-0
Methane, bromodifluoro- 1511-62-2
Methanesulfonic acid, 2-fluoroethyl ester 461-31-4
Methanesulfonic acid, 6-fluorohexyl ester 352-95-4
Methanesulfonic acid, 5-fluoroheptyl ester 352-95-4
Methanesulfonic acid, 3-fluoropropyl ester 352-95-4
Methanesulfonic acid, hydroxy-, sodium salt 870-72-4
Methanesulfonic acid, iodo-, sodium salt 126-31-8
Methanesulfonic acid, isopropyl ester 926-06-7
Methanesulfonic acid, methoxymethyl ester 25289-73-0
Methanesulfonic acid, methyl ester 66-27-3
Methanesulfonic acid,(1-methyl-2-phenethyl)hydrazino- 3583-81-1
Methane, bromodinitro- 996-67-8
Methanesulfonic acid, 1-methylpropyl ester 16156-54-0
Methanesulfonic acid, 1-methylpropyl ester, (+-)- 119943-51-0
Methanesulfonic acid, 1-methylpropyl ester, (R)- 66194-68-1
Methanesulfonic acid, 1-methylpropyl ester, (S)- 50599-13-8
Methanesulfonic acid, (methylsulfonyl)-, 2-bromoethylester 88343-74-2

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