*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PB7000000
CHEMICAL NAME : Methane, triiodo-
CAS REGISTRY NUMBER : 75-47-8
LAST UPDATED : 199801
DATA ITEMS CITED : 34
MOLECULAR FORMULA : C-H-I3
MOLECULAR WEIGHT : 393.72
WISWESSER LINE NOTATION : IYII
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Carbon triiodide
* Dezinfekt V
* Iodoform
* Jodoform
* NCI-C04568
* Triiodomethane
* Trijodmethane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 355 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1957-
Volume(issue)/page/year: 27(5),9,1983
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 165 ppm/7H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 8,59,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1184 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1957-
Volume(issue)/page/year: 27(5),9,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(11),74,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 630 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
Vascular - other changes
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,354,1962
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 1,446,1905
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1957-
Volume(issue)/page/year: 27(5),9,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 1,446,1905
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 487 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1957-
Volume(issue)/page/year: 27(5),9,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 606 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 1,446,1905
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 875 mg/kg/35D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(11),74,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2166 mg/kg/61D-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1957-
Volume(issue)/page/year: 27(5),9,1983
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 67 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 10 mg/L
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
Volume(issue)/page/year: 74,1385,1987
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 1 mg/L
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
Volume(issue)/page/year: 74,1385,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 1 mg/L
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
Volume(issue)/page/year: 74,1385,1987
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3 (0.6 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.6 ppm (10 mg/m3) JAN 1993
OEL-BELGIUM:TWA 0.6 ppm (10 mg/m3) JAN 1993
OEL-DENMARK:TWA 0.2 ppm (3 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.2 ppm (3 mg/m3);STEL 0.6 ppm (10 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 0.6 ppm (10 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 ppm (3 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.6 ppm (10 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.6 ppm (10 mg/m3);STEL 1 ppm (20 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO IODOFORM-air:10H TWA 0.6 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84474
No. of Facilities: 390 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 1882 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84474
No. of Facilities: 510 (estimated)
No. of Industries: 4
No. of Occupations: 12
No. of Employees: 22584 (estimated)
No. of Female Employees: 20381 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-110,78
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Methane, tribromo-
| 75-25-2 |
Methanetricarbonitrile, sodium salt
| 75-25-2 |
Methane, trichlorofluoro-
| 75-69-4 |
Methane, trichloronitro-
| 76-06-2 |
Methane, trichloronitroso-
| 3711-49-7 |
Methane, chlorodifluoro-
| 75-45-6 |
Methane, trifluoro-
| 75-46-7 |
Methane, trifluoroiodo-
| 2314-97-8 |
Methane, triiodo-
| 75-47-8 |
Methane, trinitro-
| 517-25-9 |
Methane, tris(4-aminophenyl)-
| 548-61-8 |
Methane, tris(propoxymethyl)nitro-
| 63869-37-4 |
Methanimidamide,N'-(8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)-N,N-dime thyl-,(1aS-(1a-alpha,8-alpha,8a-alpha,8b-alpha))-
| 105551-80-2 |
Methanimidamide, N,N'-bis(1,3-benzodioxol-5-yl)-
| 75859-60-8 |
Methanimidamide,N,N-bis(2-hydroxyethyl)-N'-(5-((2,6-dichlorophenyl)methyl)- 1,2,4-oxadiazol-3-yl)-, hydrochloride
| 70925-94-9 |
Methanimidamide, N,N'-bis(2-methoxyphenyl)-
| 68012-05-5 |
Methane, chlorodinitro-
| 921-13-1 |
Methanimidamide, N,N'-bis(5-methyl-3-isoxazolyl)-
| 75859-61-9 |
Methanimidamide, N,N'-bis(1-methyl-2-phenylethyl)-
| 61945-58-2 |
Methanimidamide,N,N'-bis(1-methyl-2-phenylethyl)-N-methyl-
| 61945-55-9 |
Methanimidamide, N,N'-bis(4-(1-oxopropoxy)phenyl)-
| 75867-01-5 |
Methanimidamide, N,N'-bis(2-phenylethyl)-, hydrate
| 2303-90-4 |
Methanimidamide, N,N'-bis(3-(trifluoromethyl)phenyl)-
| 16659-14-6 |
Methanimidamide,N'-(5-((2-chloro-6-fluorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl-
| 70926-10-2 |
Methanimidamide,N'-(5-chloro-4-formyl-1-phenyl-1H-pyrazol-3-yl)-N,N-dimethyl-
| 62208-78-0 |
Methanimidamide, N'-cyano-N,N-dimethyl-
| 39687-97-3 |
Methanimidamide,N'-(2-cyano-4-oxo-3(4H)-quinazolinyl)-N,N-dimethyl-
| 64843-08-9 |
Methane, chlorodinitroiodo-
| 40956-65-8 |
Methanimidamide,N'-(5-((2,6-dichlorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl-, hydrochloride
| 70926-03-3 |
Methanimidamide,N'-(1,6-dihydro-6-oxo-2-pyridinyl)-N,N-dipropyl-
| 111757-17-6 |
Methanimidamide,N'-(2-(3,4-dimethoxyphenyl)ethyl)-N,N-dimethyl-,phosphate (1:1)
| 61945-50-4 |
Methanimidamide,N,N-dimethyl-N'-(5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)-
| 131929-02-7 |
Methanimidamide,N,N-dimethyl-N'-(1-methyl-2-phenylethyl)-, phosphate(1:1)
| 61945-48-0 |
Methanimidamide,N,N-dimethyl-N'-(3-oxo-5-phenyl-1-cyclohexen-1-yl)-
| 131929-03-8 |
Methanimidamide,N,N-dimethyl-N'-(2-(2-oxo-1-pyrrolidinyl)ethyl)-,dihydrochloride
| 92884-75-8 |
Methanimidamide, N,N-dimethyl-N'-(2-phenylethyl)-,phosphate (1:1)
| 92884-75-8 |
Methanimidic acid,N-((2-(cyanoimino)-1-pyrrolidinyl)acetyl)-2-(2,4-dinitrophenyl)hydrazide
| 159383-33-2 |
Methanimidic acid, N-((2-oxo-1-pyrrolidinyl)acetyl)-,2-(4-nitrophenyl)hydrazide
| 95356-56-2 |
Methane, chlorofluoro-
| 593-70-4 |
4a,8a-(Methaniminomethano)naphthalene,10-(cyclopropylmethyl)-1,4,5,8-tetrahydro-,hydrochloride
| 17713-06-3 |
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-, hydrochloride
| 17730-84-6 |
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-10-methyl-, hydrochloride
| 17713-05-2 |
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-, hydrochloride
| 17730-83-5 |
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-10-methyl-, hydrochloride
| 17730-63-1 |
4a,8a-(Methaniminomethano)naphthalen-2-ol,1,2-alpha,3,4,5,6,7,8-octahydro-10-methyl-, benzoate(ester), hydrochloride
| 17713-07-4 |
4a,8a-(Methaniminomethano)naphthalen-2-ol,1,2-beta,3,4,5,6,7,8-octahydro-10-methyl-, benzoate(ester), hydrochloride
| 17747-52-3 |
9,10-Methanoanthracene,9,10-dihydro-9-gamma-methylaminopropyl-,hydrochloride
| 60070-44-2 |
2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-1 6-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6, 7,8,9,10- octahydro-5-hydroxy-,methyl ester, (3R-(3R*,5S*,7R*,9S*))-
| 67699-40-5 |
2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16- methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6, 7,8,9,10- octahydro-5-hydroxy-,methyl ester, (3R-(3R*,5S*,7R*,9S*))-,1,5-naphthalenedisulfonate (1:1) (salt)
| 99759-07-6 |
Methane, chlorotrifluoro-
| 75-72-9 |
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