*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PB6125000
CHEMICAL NAME : Methane, trichlorofluoro-
CAS REGISTRY NUMBER : 75-69-4
OTHER CAS REGISTRY NOS. : 83589-40-6
BEILSTEIN REFERENCE NO. : 1732469
REFERENCE : 4-01-00-00054 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 49
MOLECULAR FORMULA : C-Cl3-F
MOLECULAR WEIGHT : 137.36
WISWESSER LINE NOTATION : GXGGF
COMPOUND DESCRIPTOR : Tumorigen
Human
SYNONYMS/TRADE NAMES :
* Algofrene type 1
* Arcton 9
* Electro-CF 11
* Eskimon 11
* F 11
* FC 11
* Fluorocarbon No. 11
* Fluorotrichloromethane
* Fluorotrojchlorometan
* Freon 11
* Freon 11A
* Freon 11B
* Freon HE
* Freon MF
* Frigen 11
* Genetron 11
* Halocarbon 11
* Isceon 131
* Isotron 11
* Ledon 11
* Methane, fluorotrichloro-
* Monofluorotrichloromethane
* NCI-C04637
* Refrigerant 11
* Trichlorofluoromethane
* Trichloromonofluoromethane
* Ucon flurocarbon 11
* Ucon refrigerant 11
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 50000 ppm/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - fibrosing alveolitis
Liver - other changes
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >352 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520424
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13 pph/15M
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 1,239,1982
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 pph/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1743 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 18,363,1971
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 25 pph/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 25 pph/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12000 ppm/4H/10D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571425
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-CL 5620 mg/m3 (1000 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974
TOXICOLOGY REVIEW
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 3,311,1975
TOXICOLOGY REVIEW
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of
New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
Volume(issue)/page/year: 74,1939,1974
TOXICOLOGY REVIEW
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
29,517,1968
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 1000 ppm (5600 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,118,1971
OSHA PEL (Gen Indu):8H TWA 1000 ppm (5600 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1000 ppm (5600 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1000 ppm (5600 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1000 ppm (5600 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-BELGIUM:STEL 1000 ppm (5620 mg/m3) JAN 1993
OEL-DENMARK:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-FINLAND:TWA 1000 ppm (5600 mg/m3);STEL 1250 ppm (7000 mg/m3) JAN 1993
OEL-FRANCE:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-GERMANY:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-HUNGARY:STEL 40 mg/m3 JAN 1993
OEL-JAPAN:STEL 1000 ppm (5600 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-POLAND:TWA 500 mg/m3 JAN 1993
OEL-RUSSIA:STEL 1000 ppm (1000 mg/m3) JAN 1993
OEL-SWEDEN:TWA 500 ppm (3000 mg/m3);STEL 750 ppm (4500 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-TURKEY:TWA 1000 ppm (5600 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1000 ppm (5600 mg/m3);STEL 1250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUOROTRICHLOROMETHANE-air:CL 1000 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 33565
No. of Facilities: 68187 (estimated)
No. of Industries: 304
No. of Occupations: 173
No. of Employees: 785337 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 33565
No. of Facilities: 15107 (estimated)
No. of Industries: 142
No. of Occupations: 119
No. of Employees: 267742 (estimated)
No. of Female Employees: 95886 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Fluorotrichloromethane, 1006
NIOSH Analytical Method, 1994: Trichlorofluoromethane, 1006
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-106,78
NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-106,78
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Methane, tribromo-
| 75-25-2 |
Methanetricarbonitrile, sodium salt
| 75-25-2 |
Methane, trichlorofluoro-
| 75-69-4 |
Methane, trichloronitro-
| 76-06-2 |
Methane, trichloronitroso-
| 3711-49-7 |
Methane, chlorodifluoro-
| 75-45-6 |
Methane, trifluoro-
| 75-46-7 |
Methane, trifluoroiodo-
| 2314-97-8 |
Methane, triiodo-
| 75-47-8 |
Methane, trinitro-
| 517-25-9 |
Methane, tris(4-aminophenyl)-
| 548-61-8 |
Methane, tris(propoxymethyl)nitro-
| 63869-37-4 |
Methanimidamide,N'-(8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)-N,N-dime thyl-,(1aS-(1a-alpha,8-alpha,8a-alpha,8b-alpha))-
| 105551-80-2 |
Methanimidamide, N,N'-bis(1,3-benzodioxol-5-yl)-
| 75859-60-8 |
Methanimidamide,N,N-bis(2-hydroxyethyl)-N'-(5-((2,6-dichlorophenyl)methyl)- 1,2,4-oxadiazol-3-yl)-, hydrochloride
| 70925-94-9 |
Methanimidamide, N,N'-bis(2-methoxyphenyl)-
| 68012-05-5 |
Methane, chlorodinitro-
| 921-13-1 |
Methanimidamide, N,N'-bis(5-methyl-3-isoxazolyl)-
| 75859-61-9 |
Methanimidamide, N,N'-bis(1-methyl-2-phenylethyl)-
| 61945-58-2 |
Methanimidamide,N,N'-bis(1-methyl-2-phenylethyl)-N-methyl-
| 61945-55-9 |
Methanimidamide, N,N'-bis(4-(1-oxopropoxy)phenyl)-
| 75867-01-5 |
Methanimidamide, N,N'-bis(2-phenylethyl)-, hydrate
| 2303-90-4 |
Methanimidamide, N,N'-bis(3-(trifluoromethyl)phenyl)-
| 16659-14-6 |
Methanimidamide,N'-(5-((2-chloro-6-fluorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl-
| 70926-10-2 |
Methanimidamide,N'-(5-chloro-4-formyl-1-phenyl-1H-pyrazol-3-yl)-N,N-dimethyl-
| 62208-78-0 |
Methanimidamide, N'-cyano-N,N-dimethyl-
| 39687-97-3 |
Methanimidamide,N'-(2-cyano-4-oxo-3(4H)-quinazolinyl)-N,N-dimethyl-
| 64843-08-9 |
Methane, chlorodinitroiodo-
| 40956-65-8 |
Methanimidamide,N'-(5-((2,6-dichlorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl-, hydrochloride
| 70926-03-3 |
Methanimidamide,N'-(1,6-dihydro-6-oxo-2-pyridinyl)-N,N-dipropyl-
| 111757-17-6 |
Methanimidamide,N'-(2-(3,4-dimethoxyphenyl)ethyl)-N,N-dimethyl-,phosphate (1:1)
| 61945-50-4 |
Methanimidamide,N,N-dimethyl-N'-(5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)-
| 131929-02-7 |
Methanimidamide,N,N-dimethyl-N'-(1-methyl-2-phenylethyl)-, phosphate(1:1)
| 61945-48-0 |
Methanimidamide,N,N-dimethyl-N'-(3-oxo-5-phenyl-1-cyclohexen-1-yl)-
| 131929-03-8 |
Methanimidamide,N,N-dimethyl-N'-(2-(2-oxo-1-pyrrolidinyl)ethyl)-,dihydrochloride
| 92884-75-8 |
Methanimidamide, N,N-dimethyl-N'-(2-phenylethyl)-,phosphate (1:1)
| 92884-75-8 |
Methanimidic acid,N-((2-(cyanoimino)-1-pyrrolidinyl)acetyl)-2-(2,4-dinitrophenyl)hydrazide
| 159383-33-2 |
Methanimidic acid, N-((2-oxo-1-pyrrolidinyl)acetyl)-,2-(4-nitrophenyl)hydrazide
| 95356-56-2 |
Methane, chlorofluoro-
| 593-70-4 |
4a,8a-(Methaniminomethano)naphthalene,10-(cyclopropylmethyl)-1,4,5,8-tetrahydro-,hydrochloride
| 17713-06-3 |
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-, hydrochloride
| 17730-84-6 |
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-10-methyl-, hydrochloride
| 17713-05-2 |
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-, hydrochloride
| 17730-83-5 |
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-10-methyl-, hydrochloride
| 17730-63-1 |
4a,8a-(Methaniminomethano)naphthalen-2-ol,1,2-alpha,3,4,5,6,7,8-octahydro-10-methyl-, benzoate(ester), hydrochloride
| 17713-07-4 |
4a,8a-(Methaniminomethano)naphthalen-2-ol,1,2-beta,3,4,5,6,7,8-octahydro-10-methyl-, benzoate(ester), hydrochloride
| 17747-52-3 |
9,10-Methanoanthracene,9,10-dihydro-9-gamma-methylaminopropyl-,hydrochloride
| 60070-44-2 |
2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-1 6-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6, 7,8,9,10- octahydro-5-hydroxy-,methyl ester, (3R-(3R*,5S*,7R*,9S*))-
| 67699-40-5 |
2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16- methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6, 7,8,9,10- octahydro-5-hydroxy-,methyl ester, (3R-(3R*,5S*,7R*,9S*))-,1,5-naphthalenedisulfonate (1:1) (salt)
| 99759-07-6 |
Methane, chlorotrifluoro-
| 75-72-9 |
|
|