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MSDS  : Methane, trichloronitro-
CAS  : 76-06-2
SYNONYMS  : * Acquinite * Chloorpikrine * Chloroform, nitro- * Chloropicrin * Chloropicrine * Chlorpikrin * Cloropicrina * Dojyopicrin * Dolochlor * G 25 * KLOP * Larvacide * Microlysin * NCI-C00533 * Nitrochloroform * Nitrotrichloromethane * Pic-Clor * Picfume * Picride * Profume A * PS * Trichloornitromethaan * Trichlornitromethan * Trichloronitromethane * Tri-clor * Tricloro-nitro-metano
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : PB6300000
CHEMICAL NAME : Methane, trichloronitro-
CAS REGISTRY NUMBER : 76-06-2
BEILSTEIN REFERENCE NO. : 1756135
REFERENCE : 4-01-00-00106 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 48
MOLECULAR FORMULA : C-Cl3-N-O2
MOLECULAR WEIGHT : 164.37
WISWESSER LINE NOTATION : WNXGGG
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Acquinite
* Chloorpikrine
* Chloroform, nitro-
* Chloropicrin
* Chloropicrine
* Chlorpikrin
* Cloropicrina
* Dojyopicrin
* Dolochlor
* G 25
* KLOP
* Larvacide
* Microlysin
* NCI-C00533
* Nitrochloroform
* Nitrotrichloromethane
* Pic-Clor
* Picfume
* Picride
* Profume A
* PS
* Trichloornitromethaan
* Trichlornitromethan
* Trichloronitromethane
* Tri-clor
* Tricloro-nitro-metano

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 2 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 106,296,1939

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 2000 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,169,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and
Environment Research, Toxicology Research Lab., Midland, MI 48640)
Volume(issue)/page/year: -,-,1972

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14400 ppb/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 16,63,1991

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 66 mg/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - increased intraocular pressure
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 15,406,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 10(6),53,1976

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 800 mg/m3/20M
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 106,296,1939

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 800 mg/m3/20M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C72,1991

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 800 mg/m3/20M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 106,296,1939

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 4200 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 114,146,1958

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 17,125,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2880 mg/kg/90D-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 17,125,1994

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 26 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-65,1978

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,185,1983

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 50 ug/plate
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 29,34,1987

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 300 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 348,147,1995

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 8 mg/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
10,21,1990

*** REVIEWS ***

ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-TWA 0.67 mg/m3 (0.1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

MSHA STANDARD-air:TWA 0.1 ppm (0.7 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,54,1971

OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993

OEL-AUSTRIA:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-BELGIUM:TWA 0.1 ppm (0.67 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993

OEL-DENMARK:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-FINLAND:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2.1 mg/m3) JAN 1993

OEL-FRANCE:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-GERMANY:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-JAPAN:TWA 0.1 ppm (0.67 mg/m3) JAN 1993

OEL-THE NETHERLANDS:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-THE PHILIPPINES:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-RUSSIA:TWA 0.1 ppm JAN 1993

OEL-SWITZERLAND:TWA 0.1 ppm (0.7 mg/m3);STEL 0.2 ppm (1.4 mg/m3) JAN 1993

OEL-TURKEY:TWA 0.1 ppm (0.7 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLOROPICRIN-air:10H TWA 0.1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0419
No. of Facilities: 484 (estimated)
No. of Industries: 3
No. of Occupations: 8
No. of Employees: 4843 (estimated)
No. of Female Employees: 939 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NCI Carcinogenesis Bioassay (gavage);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-65,78

NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-65,78


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Methane, tribromo- 75-25-2
Methanetricarbonitrile, sodium salt 75-25-2
Methane, trichlorofluoro- 75-69-4
Methane, trichloronitro- 76-06-2
Methane, trichloronitroso- 3711-49-7
Methane, chlorodifluoro- 75-45-6
Methane, trifluoro- 75-46-7
Methane, trifluoroiodo- 2314-97-8
Methane, triiodo- 75-47-8
Methane, trinitro- 517-25-9
Methane, tris(4-aminophenyl)- 548-61-8
Methane, tris(propoxymethyl)nitro- 63869-37-4
Methanimidamide,N'-(8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)-N,N-dime thyl-,(1aS-(1a-alpha,8-alpha,8a-alpha,8b-alpha))- 105551-80-2
Methanimidamide, N,N'-bis(1,3-benzodioxol-5-yl)- 75859-60-8
Methanimidamide,N,N-bis(2-hydroxyethyl)-N'-(5-((2,6-dichlorophenyl)methyl)- 1,2,4-oxadiazol-3-yl)-, hydrochloride 70925-94-9
Methanimidamide, N,N'-bis(2-methoxyphenyl)- 68012-05-5
Methane, chlorodinitro- 921-13-1
Methanimidamide, N,N'-bis(5-methyl-3-isoxazolyl)- 75859-61-9
Methanimidamide, N,N'-bis(1-methyl-2-phenylethyl)- 61945-58-2
Methanimidamide,N,N'-bis(1-methyl-2-phenylethyl)-N-methyl- 61945-55-9
Methanimidamide, N,N'-bis(4-(1-oxopropoxy)phenyl)- 75867-01-5
Methanimidamide, N,N'-bis(2-phenylethyl)-, hydrate 2303-90-4
Methanimidamide, N,N'-bis(3-(trifluoromethyl)phenyl)- 16659-14-6
Methanimidamide,N'-(5-((2-chloro-6-fluorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl- 70926-10-2
Methanimidamide,N'-(5-chloro-4-formyl-1-phenyl-1H-pyrazol-3-yl)-N,N-dimethyl- 62208-78-0
Methanimidamide, N'-cyano-N,N-dimethyl- 39687-97-3
Methanimidamide,N'-(2-cyano-4-oxo-3(4H)-quinazolinyl)-N,N-dimethyl- 64843-08-9
Methane, chlorodinitroiodo- 40956-65-8
Methanimidamide,N'-(5-((2,6-dichlorophenyl)methyl)-1,2,4-oxadiazol-3-yl)-N,N-dimethyl-, hydrochloride 70926-03-3
Methanimidamide,N'-(1,6-dihydro-6-oxo-2-pyridinyl)-N,N-dipropyl- 111757-17-6
Methanimidamide,N'-(2-(3,4-dimethoxyphenyl)ethyl)-N,N-dimethyl-,phosphate (1:1) 61945-50-4
Methanimidamide,N,N-dimethyl-N'-(5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)- 131929-02-7
Methanimidamide,N,N-dimethyl-N'-(1-methyl-2-phenylethyl)-, phosphate(1:1) 61945-48-0
Methanimidamide,N,N-dimethyl-N'-(3-oxo-5-phenyl-1-cyclohexen-1-yl)- 131929-03-8
Methanimidamide,N,N-dimethyl-N'-(2-(2-oxo-1-pyrrolidinyl)ethyl)-,dihydrochloride 92884-75-8
Methanimidamide, N,N-dimethyl-N'-(2-phenylethyl)-,phosphate (1:1) 92884-75-8
Methanimidic acid,N-((2-(cyanoimino)-1-pyrrolidinyl)acetyl)-2-(2,4-dinitrophenyl)hydrazide 159383-33-2
Methanimidic acid, N-((2-oxo-1-pyrrolidinyl)acetyl)-,2-(4-nitrophenyl)hydrazide 95356-56-2
Methane, chlorofluoro- 593-70-4
4a,8a-(Methaniminomethano)naphthalene,10-(cyclopropylmethyl)-1,4,5,8-tetrahydro-,hydrochloride 17713-06-3
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-, hydrochloride 17730-84-6
4a,8a-(Methaniminomethano)naphthalene,1,2,3,4,5,8-hexahydro-10-methyl-, hydrochloride 17713-05-2
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-, hydrochloride 17730-83-5
4a,8a-(Methaniminomethano)naphthalene,1,4,5,8-tetrahydro-10-methyl-, hydrochloride 17730-63-1
4a,8a-(Methaniminomethano)naphthalen-2-ol,1,2-alpha,3,4,5,6,7,8-octahydro-10-methyl-, benzoate(ester), hydrochloride 17713-07-4
4a,8a-(Methaniminomethano)naphthalen-2-ol,1,2-beta,3,4,5,6,7,8-octahydro-10-methyl-, benzoate(ester), hydrochloride 17747-52-3
9,10-Methanoanthracene,9,10-dihydro-9-gamma-methylaminopropyl-,hydrochloride 60070-44-2
2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-1 6-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6, 7,8,9,10- octahydro-5-hydroxy-,methyl ester, (3R-(3R*,5S*,7R*,9S*))- 67699-40-5
2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16- methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6, 7,8,9,10- octahydro-5-hydroxy-,methyl ester, (3R-(3R*,5S*,7R*,9S*))-,1,5-naphthalenedisulfonate (1:1) (salt) 99759-07-6
Methane, chlorotrifluoro- 75-72-9

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