*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PY5788000
CHEMICAL NAME : Milbemycin B,
5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-,
(6R,25R)-
CAS REGISTRY NUMBER : 77855-81-3
BEILSTEIN REFERENCE NO. : 4282549
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C33-H48-O7
MOLECULAR WEIGHT : 556.81
COMPOUND DESCRIPTOR : Natural Product
SYNONYMS/TRADE NAMES :
* Antibiotic B 41D
* B 41D
* (6R,25)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)milbemycin B
* Milbemycin D
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2467 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 35,71,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 35,71,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Blood - hemorrhage
Blood - changes in spleen
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 35,71,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1610 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 35,71,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 668 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 35,71,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Blood - hemorrhage
Blood - changes in spleen
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 35,71,1983
*** END OF RECORD ***
|
|
|
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Methyldihydrocodeinone enol acetate
| 69928-60-5 |
Methyl ether
| 115-10-6 |
Methyl Green
| 54327-10-5 |
Methylium, tris(4-aminophenyl)-, salt with4,4'-methylenebis(3-hydroxy-2-naphthalene carboxylicacid) (2:1)
| 2706-47-0 |
Methyl sulfide
| 75-18-3 |
Methyl sulfide, compd. with borane (11)
| 13292-87-0 |
Methylsulfonamide, N-(1-(phenylmethyl)cyclopentyl)-
| 13292-87-0 |
Methyl sulfoxide
| 67-68-5 |
Methyl sulfoxide, mixed with(alpha,alpha-dimethylbenzyl)hydroperoxide
| 67-68-5 |
Methylviolet carbinol
| 39425-26-8 |
Methanone,(2-chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imidazol-1-yl)-5-nitrophen yl)-, trans-2-butenedioate
| 54533-86-7 |
Metiram, methyl-
| 8064-35-5 |
Metiram, mixt. with sulfur
| 57693-13-7 |
Meuhlenbeckia platyclados Meissn., stem extractSUBSTANCE DEFINITION :Plant belonging to the family PolygonaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 57693-13-7 |
Meyna laxiflora Robyns, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RubiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 57693-13-7 |
Mezoneuron cucullatum Wt. & Arn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 15,208,1977
| 57693-13-7 |
Mezzanomycin
| 102534-96-3 |
MGV-5SUBSTANCE DEFINITION :Composed of disodium sulfate, monosodium carbonate, potassium chloride,sodium chloride and PEG 4000REFERENCE :YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu SaiensuShuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-Volume(issue)/page/year: 17,3067,1989
| 102534-96-3 |
MH 101, high-boiling petroleum productSUBSTANCE DEFINITION :A petroleum derivative, high-boiling catalytically cracked oilREFERENCE :CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & ChestnutSts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:16,951,1956
| 102534-96-3 |
Miamycin
| 102534-88-3 |
Micanite
| 55840-10-3 |
Methanone,(2-chlorophenyl)(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-
| 123769-35-7 |
Michelia cathcartii Hook. f. & Thoms., stem barkextractSUBSTANCE DEFINITION :Plant belonging to the family MagnoliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 123769-35-7 |
Michelia excelsa Bl., extract excluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family MagnoliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 123769-35-7 |
Michelia kisopa Buch.-Ham. ex DC., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family MagnoliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 123769-35-7 |
Micoluteina destacina
| 12764-47-5 |
Microcin
| 73904-91-3 |
Microcin A
| 1403-96-9 |
Microcin B
| 1403-97-0 |
Micrococcin P,13',19'-didehydro-19'-deoxy-28,44-dihydro-44-hydroxy-
| 67401-56-3 |
Microcos paniculata Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family TiliaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 67401-56-3 |
Microcystin
| 77238-39-2 |
Methanone,(4-chlorophenyl)(1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)-4-piperidiny l)-, hydrochloride
| 76362-14-6 |
Microcystis aeruginosa, algal bloom
| 76362-14-6 |
Micromeles polycarpa (Hook.f.) Panigrahi, extractexcluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family RosaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 76362-14-6 |
Micromelum pubescens Bl. var. integerrima (Roxb.)Hook.f., extract excluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family RutaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 76362-14-6 |
Microsorium membranaceum (D. Don) Ching, extractSUBSTANCE DEFINITION :Plant belonging to the family PolypodiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 76362-14-6 |
Microtropis discolor Wall., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family CelastraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 76362-14-6 |
Microtropis microcarpa Wight, extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family CelastraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 76362-14-6 |
Microtropis stocksii Gamble, extract excluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family CelastraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 76362-14-6 |
Miharamycin-A
| 12626-16-3 |
Miharamycin B
| 12626-15-2 |
Mikania cordata (burm.) B. L. Robins, extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 7,250,1969
| 12626-15-2 |
Methanone,(4-chlorophenyl)(4-(beta-D-galactopyranosyloxy)phenyl)-, hemihydrate
| 83357-01-1 |
Milbemycin B,5-O-demethyl-28-deoxy-6,28-epoxy-25-methyl-,(6R,25R)- mixt. with(6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-milbemycin B (3:7)
| 83357-01-1 |
Milbemycin B,5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-,(6R,25R)-
| 77855-81-3 |
Mildiomycin
| 67527-71-3 |
Miliosma pinnata (Roxb.)Maxim ssp. barbulata (Cubod.)Beus, extract excluding rootSUBSTANCE DEFINITION :Indian plant belonging to the family SabiaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 67527-71-3 |
Miliusa macrocarpa Hook.f.& Thoms., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family AnnonaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 67527-71-3 |
Miliusa montana Gardn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family AnnonaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 67527-71-3 |
|
|