*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QR7040000
CHEMICAL NAME : Nickel(II) hydroxide
CAS REGISTRY NUMBER : 12054-48-7
LAST UPDATED : 199712
DATA ITEMS CITED : 43
MOLECULAR FORMULA : H2-Ni-O2
MOLECULAR WEIGHT : 92.73
WISWESSER LINE NOTATION : .NI..Q2
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Nickel dihydroxide
* Nickelous hydroxide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1515 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 1,684,1992
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1200 mg/m3/4H
TOXIC EFFECTS :
Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
REFERENCE :
RCCRC* Research and Consulting Company, Technical Reports. (RCC NOTOX B.V.,
Hambakenwetering 7, 5231 DD 's-Hertogenbosch, Netherlands)
Volume(issue)/page/year: NOTOX1074,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCCRC* Research and Consulting Company, Technical Reports. (RCC NOTOX B.V.,
Hambakenwetering 7, 5231 DD 's-Hertogenbosch, Netherlands)
Volume(issue)/page/year: NOTOX1074/1338,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva.
Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-
Volume(issue)/page/year: 19,186,1974
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 480 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,275,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
45ICAX "Nickel Toxicology, 2nd International Conference on Nickel
Toxicology, Swansea, Wales, 1980," London, Academic Press Inc., Ltd., 1980
Volume(issue)/page/year: -,59,1980
*** REVIEWS ***
ACGIH TLV-TWA 1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 11,75,1976
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 49,257,1990
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Ni,168,1975
TOXICOLOGY REVIEW
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 3,156,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,178,1971
OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993
OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993
OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-BELGIUM:TWA 1 mg(Ni)/m3 JAN 1993
OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen JAN 1993
OEL-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN 1993
OEL-FRANCE:TWA 1 mg(Ni)/m3 JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN 1993
OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993
OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993
OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7142
No. of Facilities: 53 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 106 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***
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