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MSDS  : Nickel(II) sulfate (11)
CAS  : 7786-81-4
SYNONYMS  : * NCI-C60344 * Nickelous sulfate * Nickel sulfate * Nickel sulfate(1:1) * Nickel(II) sulfate * Nickel(2+)sulfate(1:1) * Sulfuric acid, nickel(2+)salt * Sulfuric acid, nickel(2+) salt (1:1)
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : QR9350000
CHEMICAL NAME : Nickel(II) sulfate (1:1)
CAS REGISTRY NUMBER : 7786-81-4
LAST UPDATED : 199712
DATA ITEMS CITED : 61
MOLECULAR FORMULA : O4-S.Ni
MOLECULAR WEIGHT : 154.77
WISWESSER LINE NOTATION : NI S-O4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* NCI-C60344
* Nickelous sulfate
* Nickel sulfate
* Nickel sulfate(1:1)
* Nickel(II) sulfate
* Nickel(2+)sulfate(1:1)
* Sulfuric acid, nickel(2+)salt
* Sulfuric acid, nickel(2+) salt (1:1)

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human - child
DOSE/DURATION : 5%/48H
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.82- 1960- Volume(issue)/page/year: 87,378,1963

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Gastrointestinal - changes in structure or function of salivary glands
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 23(6),48,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20894 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
Volume(issue)/page/year: 256,1043,1963

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7640 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - fluid intake
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 23,549,1960

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 8,565,1908

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 8,565,1908

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 8,565,1908

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 8,565,1908

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 8,565,1908

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14 mg/kg/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,177,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg/20D-I
TOXIC EFFECTS :
Endocrine - hyperglycemia
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 23(6),48,1979

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/m3/4H/39W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 23(6),48,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 71226 mg/kg/26W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decreased immune response
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 24,357,1988

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 95 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 5,50,1964

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,149,1983

TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,149,1983

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,3815,1987

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Kidney
DOSE/DURATION : 5 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
49,1829,1989

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Kidney
DOSE/DURATION : 5 mg/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 27,136,1986

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 23 umol/L
REFERENCE :
DMBUAE Danish Medical Bulletin. (Copenhagen, Denmark) V.1-18, 1954-71.
Volume(issue)/page/year: 27,40,1980

TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Human Kidney
DOSE/DURATION : 5 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
49,1829,1989

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 380 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,193,1979

*** REVIEWS ***

ACGIH TLV-TWA 0.1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 49,257,1990

IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 49,257,1990

TOXICOLOGY REVIEW
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 3,156,1973

TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Ni,168,1975

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,178,1971

OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993

OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993

OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen JAN 1993

OEL-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN 1993

OEL-FRANCE:TWA 1 mg(Ni)/m3 JAN 1993

OEL-GERMANY;Carcinogen JAN 1993

OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN 1993

OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993

OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993

OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993

OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993

OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 50510
No. of Facilities: 2205 (estimated)
No. of Industries: 53
No. of Occupations: 26
No. of Employees: 13210 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 50510
No. of Facilities: 3480 (estimated)
No. of Industries: 67
No. of Occupations: 45
No. of Employees: 56844 (estimated)
No. of Female Employees: 12029 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE

EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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NAMECAS
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Nickel, (carbonato(2-))tetrahydroxytri-, tetrahydrate 39430-27-8
Nickel carbonyl 13463-39-3
Nickel(II) chloride (12) 7718-54-9
Nickel(II) chloride, hexahydrate (126) 7791-20-0
Nickel chloride, trihydrate 65374-81-4
Nickel cyanide 557-19-7
Nickel, compd with pi-cyclopentadienyl (12) 1271-28-9
2-Naphthol, 1,6-dibromo- 16239-18-2
Nickel, dithiocyanatobis(triphenylphosphine)- 15709-62-3
Nickel,(ethanedioato(2-)-O,O')bis(3-methylbenzenamine)- 80660-65-7
Nickel,(ethanedioato(2-)-O,O')bis(3-((phenylamino)methyl)-2(3H)-benzoxazolone- N(sup N(sup 3),O(sup 2))- 82497-99-2
Nickel, (ethanedioato(2-)-O,O')bis(pyridine1-oxide-O)-, (SP-4-2)- 74167-24-1
Nickel(II) fluoborate 14708-14-6
Nickel(II) fluoride (12) 10028-18-9
Nickel(II) fluosilicate (11) 26043-11-8
Nickel-gallium alloy 56668-59-8
Nickel(II) hydroxide 12054-48-7
Nickel(III) hydroxide 12125-56-3
2-Naphthol, dichloro- 63980-33-6
Nickeline 1303-13-5
Nickel iron sulfide 59978-65-3
Nickel(II) isodecyl ortho-phosphate (32) 74203-45-5
Nickel(II) nitrate (12) 13138-45-9
Nickel(II) nitrate, hexahydrate (126) 13478-00-7
Nickel(II) oxide (11) 1313-99-1
Nickel(III) oxide 1314-06-3
Nickel oxide catalyst 1314-06-3
Nickel potassium cyanide 14220-17-8
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Nickel selenide (Ni-Se) 1314-05-2
Nickel selenide (Ni3-Se2) 12137-13-2
Nickel (II) sulfamate 13770-89-3
Nickel(II) sulfate (11) 7786-81-4
Nickel(II) sulfate hexahydrate (116) 10101-97-0
Nickel sulfide 11113-75-0
Nickel sulfide 16812-54-7
Nickel sulfide 12035-51-7
Nickel sulfide, amorphous 12035-51-7
Nickel sulfide (32) 12035-72-2
2-Naphthol, 1-((2,5-dimethoxyphenyl)azo)- 6358-53-8
Nickel telluride 12142-88-0
Nickel titanium oxide 12035-39-1
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Nickel(2+), tris(octamethylpyrophosphoramide)-,diperchlorate 26388-85-2
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