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MSDS  : p-Phenylenediamine
CAS  : 106-50-3
SYNONYMS  : * p-Aminoaniline * 4-Aminoaniline * BASF ursol D * p-Benzenediamine * 1,4-Benzenediamine * Benzofur D * C.I. 76060 * C.I. Developer 13 * C.I. Oxidation Base 10 * Developer 13 * Developer PF * p-Diaminobenzene * 1,4-Diaminobenzene * Durafur Black R * p-Fenylendiamin * Fenylenodwuamina * Fouramine D * Fourrine D * Fourrine 1 * Fur Black 41867 * FUR Brown 41866 * Furro D * Fur Yellow * Futramine D * Nako H * Orsin * Oxidation Base 10 * Paraphenylen-diamine * Pelagol D * Pelagol DR * Pelagol Grey D * Peltol D * 1,4-Phenylenediamine * p-Phenylenediamine * 6PPD * Renal PF * Rodol D * Santoflex IC * Tertral D * Ursol D * USAF EK-394 * Zoba Black D
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SS8050000
CHEMICAL NAME : p-Phenylenediamine
CAS REGISTRY NUMBER : 106-50-3
LAST UPDATED : 199712
DATA ITEMS CITED : 80
MOLECULAR FORMULA : C6-H8-N2
MOLECULAR WEIGHT : 108.16
WISWESSER LINE NOTATION : ZR DZ
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* p-Aminoaniline
* 4-Aminoaniline
* BASF ursol D
* p-Benzenediamine
* 1,4-Benzenediamine
* Benzofur D
* C.I. 76060
* C.I. Developer 13
* C.I. Oxidation Base 10
* Developer 13
* Developer PF
* p-Diaminobenzene
* 1,4-Diaminobenzene
* Durafur Black R
* p-Fenylendiamin
* Fenylenodwuamina
* Fouramine D
* Fourrine D
* Fourrine 1
* Fur Black 41867
* FUR Brown 41866
* Furro D
* Fur Yellow
* Futramine D
* Nako H
* Orsin
* Oxidation Base 10
* Paraphenylen-diamine
* Pelagol D
* Pelagol DR
* Pelagol Grey D
* Peltol D
* 1,4-Phenylenediamine
* p-Phenylenediamine
* 6PPD
* Renal PF
* Rodol D
* Santoflex IC
* Tertral D
* Ursol D
* USAF EK-394
* Zoba Black D

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 250 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 23,371,1972

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 23,371,1972

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 250 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 23,371,1972

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 12500 ug/24H
REACTION SEVERITY : Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 15,607,1977

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 250 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 23,371,1972

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 250 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 23,371,1972

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 250 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 23,371,1972

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 71 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 8,345,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,657,1977

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 920 mg/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0530403

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,657,1977

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 170 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale
des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000
Liege, Belgium) V.1- 1932- Volume(issue)/page/year: 41,302,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 133 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(8),46,1987

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 23(5),14,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
Volume(issue)/page/year: 12,500,1961

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 331 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 50(6),78,1985

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - nausea or vomiting
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)
Volume(issue)/page/year: 271,40,1941

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,657,1977

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals
Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year:
42,473,1928

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For
publisher information, see AEHLAU. Volume(issue)/page/year: 4,386,1923

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.1- 1908- Volume(issue)/page/year: 36,724,1925

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 53(7),62,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(8),46,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1050 mg/kg/30W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - alteration of classical conditioning
Liver - fatty liver degeneration
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 23(5),14,1958

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28 gm/kg/80W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 16,259,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16800 mg/kg/12W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 16,259,1983

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 105 mg/kg/30W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - fatty liver degeneration
Liver - liver function tests impaired
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 23(5),14,1958

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2625 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
KJMSAH Kyushu Journal of Medical Science. (Fukuoka, Japan) V.6-15,
1955-64. Discontinued. Volume(issue)/page/year: 9,94,1958

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 2 umol/plate
REFERENCE :
45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,185,1987

TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 125 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,349,1991

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 15500 umol/L/3D
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,181,1977

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 1850 ng/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 1,190,1981

TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 15 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
27,67,1996

*** REVIEWS ***

ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-TWA 0.1 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,125,1978

IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,125,1978

IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987

TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 4(3),203,1985

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 0.1 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,205,1971

OSHA PEL (Gen Indu):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 0.1 mg/m3;Skin JAN 1993

OEL-BELGIUM:TWA 0.1 mg/m3;Skin JAN 1993

OEL-DENMARK:TWA 0.1 mg/m3;Skin JAN 1993

OEL-FINLAND:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993

OEL-FRANCE:TWA 0.1 mg/m3;Skin JAN 1993

OEL-GERMANY:TWA 0.1 mg/m3;Skin JAN 1993

OEL-THE NETHERLANDS:TWA 0.1 mg/m3;Skin JAN 1993

OEL-THE PHILIPPINES:TWA 0.1 mg/m3;Skin JAN 1993

OEL-POLAND:TWA 0.1 mg/m3 JAN 1993

OEL-RUSSIA:STEL 0.05 mg/m3 JAN 1993

OEL-SWEDEN:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993

OEL-SWITZERLAND:TWA 0.1 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993

OEL-UNITED KINGDOM:TWA 0.1 mg/m3;Skin JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO p-PHENYLENE DIAMINE-air:10H TWA 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 56950
No. of Facilities: 2017 (estimated)
No. of Industries: 9
No. of Occupations: 11
No. of Employees: 14983 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 56950
No. of Facilities: 5390 (estimated)
No. of Industries: 6
No. of Occupations: 7
No. of Employees: 49939 (estimated)
No. of Female Employees: 37209 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; D melanogaster
Sex-linked lethal

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Rodent
dominant lethal

EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Sperm
morphology-mouse

EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phenol, pentachloro-, acetate 1441-02-7
DL-Phenylalanine, N-(1H-indol-3-yloxoacetyl)-, ethylester 97529-42-5
DL-Phenylalanine, 2-methoxy-5-nitro-, ethyl ester,monohydrochloride 116366-15-5
L-Phenylalanine,N-(1-(2-methyl-1-oxo-3-((1-oxopropyl)thio)propyl)-L-prolyl)-, (S)- 74259-02-2
L-Phenylalanine,N-((4-(((2-methylpropoxy)carbonyl)amino)phenyl)sulfonyl)-, ethyl ester 81865-24-9
D-Phenylalanine, N-(3-(4-nitrophenyl)-3-oxopropyl)- 85975-29-7
D-Phenylalanine, N-(3-(4-nitrophenyl)-3-oxopropyl)-,monohydrochloride 85975-17-3
DL-Phenylalanine, N-((5-nitro-2-thienyl)carbonyl)-,(3-(5-nitro-2-furanyl)-2-propenylidene) hydrazide 39978-55-7
L-Phenylalanine,2-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)hydrazide 84409-81-4
DL-Phenylalanine, N-(1-oxo-3-phenyl-2-propenyl)-,methyl ester, (E)- 127750-60-1
DL-Phenylalanine, N-(3-oxo-3-phenylpropyl)- 85995-02-4
Phenol, pentachloro-, mixt. with chlorinated paraffinoils and 1-chloronaphthalene 70645-04-4
DL-Phenylalanine, N-(3-oxo-3-phenylpropyl)-,hydrochloride 85975-14-0
DL-Phenylalanine,N-(3-oxo-3-(4-propoxyphenyl)propyl)- 85975-28-6
DL-Phenylalanine,N-(3-oxo-3-(4-propoxyphenyl)propyl)-, hydrochloride 85975-15-1
Phenylalanine, alpha-phenyl- 56594-95-7
L-Phenylalanine, N-((phenylmethoxy)carbonyl)-,ethenyl ester 64187-42-4
Phenylalanine, 2-(phosphonomethyl)-, hydrate 110762-24-8
L-Phenylalanine, 4-(1-piperidinyl)-, beta- 71825-29-1
L-Phenylalanine,L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucy- L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leu cyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lys yl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt), hydrate 99294-94-7
Phenyl disulfide 882-33-7
m-Phenylenediamine 108-45-2
Phenol, pentachloro-, p-chlorobenzoate 2948-12-1
o-Phenylenediamine 95-54-5
p-Phenylenediamine 106-50-3
o-Phenylenediamine, 4-(p-aminophenoxy)- 6264-66-0
o-Phenylenediamine, 4-arsenoso-, hydrochloride,hydrate (1:1:3) 6264-66-0
p-Phenylenediamine, N,N-bis(2-chloroethyl)- 2067-58-5
p-Phenylenediamine, N,N-bis(2-chloroethyl)-,hydrochloride 36134-83-5
p-Phenylenediamine, N,N'-bis(1,4-dimethylpentyl)- 3081-14-9
p-Phenylenediamine, N,N'-bis(1-ethyl-3-methylpentyl)- 139-60-6
p-Phenylenediamine, N,N-bis(2-hydroxyethyl)-, sulfate(1:1) 63886-75-9
m-Phenylenediamine, 4-butoxy-, dihydrochloride 76486-09-4
Phenol, m-(pentachlorophenoxy)- 76486-09-4
m-Phenylenediamine, 4-chloro- 5131-60-2
o-Phenylenediamine, 4-chloro- 95-83-0
p-Phenylenediamine, 2-chloro- 615-66-7
o-Phenylenediamine,4-chloro-N-(2-(diethylamino)ethyl)- 56756-64-0
p-Phenylenediamine, 2-chloro-, dihydrochloride 615-46-3
p-Phenylenediamine, 2-chloro-, sulfate 6219-71-2
p-Phenylenediamine, N,N'-di-sec-butyl- 101-96-2
p-Phenylenediamine, N,N'-dibutyl-N,N'-dinitroso- 19433-82-0
p-Phenylenediamine, 2,5-dichloro- 20103-09-7
p-Phenylenediamine, 2,6-dichloro- 609-20-1
Phenol, 2-(pentachlorophenoxy)- 78576-68-8
p-Phenylenediamine, N,N'-dicyclohexyl- 4175-38-6
p-Phenylenediamine, N,N-diethyl- 93-05-0
p-Phenylenediamine, N,N'-diethyl- 3010-30-8
o-Phenylenediamine, N-(2-(diethylamino)ethyl)-,dihydrochloride 101976-54-9
p-Phenylenediamine, N,N-diethyl-N',N'-dimethyl- 5775-53-1

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