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MSDS  : Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
CAS  : 92-31-9
SYNONYMS  : * Blutene chloride * C.I. Basic Blue 17 * Dimethyltoluthionine chloride * F Klot * Gabilin * Klot * Menodin * Modr Toluidinova * Modr Zasadita 17 * Schultz 1041 * Tolazul * Tolonium chloride * Toluidinblau * Toluidine Blue * Toluidine Blue O * Toluidine Blue OO * Toluidine Blue (phenothiazine dye)
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SP5670000
CHEMICAL NAME : Phenothiazin-5-ium,
3-amino-7-(dimethylamino)-2-methyl-, chloride
CAS REGISTRY NUMBER : 92-31-9
LAST UPDATED : 199706
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C15-H16-N3-S.Cl
MOLECULAR WEIGHT : 305.85
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Blutene chloride
* C.I. Basic Blue 17
* Dimethyltoluthionine chloride
* F Klot
* Gabilin
* Klot
* Menodin
* Modr Toluidinova
* Modr Zasadita 17
* Schultz 1041
* Tolazul
* Tolonium chloride
* Toluidinblau
* Toluidine Blue
* Toluidine Blue O
* Toluidine Blue OO
* Toluidine Blue (phenothiazine dye)

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 43 mg/kg/6D
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - other changes
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,597,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 204,288,1947

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28930 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 27560 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 17,902,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 13440 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,255,1992

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 500 ppm
REFERENCE :
14ZYA8 "Induction of Mutations and the Mutation Process, Proceedings of a
Symposium, Prague, Czechoslovakia, 1963," Veleminsky, J., and T. Gichnar,
eds., Prague, Academia, 1965 Volume(issue)/page/year: -,115,1965

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1164
No. of Facilities: 224 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1226 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1164
No. of Facilities: 196 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 7956 (estimated)
No. of Female Employees: 5824 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; S cerevisiae
gene conversion

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phenol, o-octyl- 949-13-3
10H-Phenothiazine,10-(((tetrahydro-5-((4-methoxyphenyl)methylene)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-62-0
10H-Phenothiazine,10-(((tetrahydro-5-(((2-methylphenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-50-6
10H-Phenothiazine,10-(((tetrahydro-5-(((3-methylphenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-48-2
10H-Phenothiazine,10-(((tetrahydro-5-((4-morpholinylamino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-53-9
10H-Phenothiazine,10-(((tetrahydro-5-((1-naphthalenylamino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-58-4
10H-Phenothiazine,10-(((tetrahydro-5-(((3-nitrophenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-55-1
10H-Phenothiazine,10-(((tetrahydro-5-(((4-nitrophenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)- 141177-54-0
10H-Phenothiazine,10-(2-(2,2,6,6-tetramethyl-1-piperidinyl)ethyl)-,monohydrochloride 141177-54-0
10H-Phenothiazine,10-((2,4,6-tribromophenoxy)acetyl)- 136776-26-6
Phenothiazine, 2-(trifluoromethyl)- 92-30-8
Phenol, 3-(1-oxa-4-azaspiro(4.5)dec-2-yl)- 25283-29-8
Phenothiazine, 4-(trifluoromethyl)- 343-21-5
10H-Phenothiazine,10-(((1-(2,3,4-trihydroxyphenyl)ethylidene)hydrazino)acetyl)- 68026-86-8
10H-Phenothiazine,10-((2,4,6-trinitrophenoxy)acetyl)- 136776-24-4
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-,chloride 531-53-3
Phenothiazin-5-ium,3-amino-7-(dimethylamino)-2-methyl-, chloride 92-31-9
Phenothiazin-5-ium, 3-amino-7-methylamino-, chloride 531-57-7
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-,chloride, trihydrate 7220-79-3
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-4-nitro-,chloride 2679-01-8
Phenoxarsine, 10-chloro- 2865-70-5
Phenoxarsine,10-((N,N-dimethylamino)thiocarbonylthio)- 2865-70-5
Phenol, 2-(1,3,4-oxadiazol-2-yl)- 1008-65-7
Phenoxarsine, 10,10'-oxydi- 58-36-6
Phenoxarsine, 10-((phenoxyacetyl)thio)- 7393-66-0
Phenoxathiin 262-20-4
Phenoxathiin, 2-dichloroarsino- 63834-20-8
Phenoxathiin, 10,10-dioxide 950-47-0
Phenoxathiinium, 2-chloro-10-methyl-,tetrafluoroborate(1-) 15615-40-4
Phenoxathiinium, 10-methyl-, tetrafluoroborate(1-) 15615-39-1
Phenoxathiin, 10-oxide 948-44-7
10H-Phenoxazine-1-carboxamide,N-(2-(dimethylamino)ethyl)- 112022-13-6
Phenoxazine-10-carbothioic acid,S-(2-(diethylamino)ethyl) ester, hydrochloride 1945-75-1
Phenol, 2,2'-(1,3,4-oxadiazol-2,5-ylene)bis(4-amino- 95452-62-3
Phenoxazine-10-carbothioic acid,S-(2-(dimethylamino)ethyl) ester, hydrochloride 1936-49-8
Phenoxazine-10-carboxylic acid, 2-(diethylamino)ethylester, hydrochloride 2278-23-1
Phenoxazine, 2-chloro-10-(3-(dimethylamino)propyl)-,hydrochloride 98175-98-5
3H-Phenoxazine-4,6-dicarboxylic acid, 2-amino-3-oxo-,dimethyl ester 35748-35-7
Phenoxazine, 10-(3-(dimethylamino)propyl)-,hydrochloride 36982-02-2
Phenoxazine, 10-(3-(dimethylamino)propyl)-, phosphate 2278-24-2
Phenoxazine, 10-(3-(4-methoxypiperidino)propyl)- 97018-26-3
Phenoxazine, 10-(3-piperidinopropyl)- 95554-67-9
Phenoxazin-5-ium,7-amino-3-(dimethylamino)-2-methyl-, chloride 63834-21-9
Phenoxazin-5-ium,3-(diethylamino)-7-(dimethylamino)-2-methyl-,chloride 1787-57-1
Phenol, o,o'-(1,3,4-oxadiazol-2,5-ylene)di- 2491-96-5
Phenoxazin-5-ium,1-carboxy-7-(dimethylamino)-3,4-dihydroxy-, chloride 1562-85-2
3H-Phenoxazin-3-one, 2-amino- 1916-59-2
3H-Phenoxazin-3-one, 7-hydroxy- 635-78-9
3H-Phenoxazin-3-one, 7-hydroxy-, 10-oxide 550-82-3
Phenoxysulfonyl fluoride 330-00-7

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