*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SP5670000
CHEMICAL NAME : Phenothiazin-5-ium,
3-amino-7-(dimethylamino)-2-methyl-, chloride
CAS REGISTRY NUMBER : 92-31-9
LAST UPDATED : 199706
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C15-H16-N3-S.Cl
MOLECULAR WEIGHT : 305.85
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Blutene chloride
* C.I. Basic Blue 17
* Dimethyltoluthionine chloride
* F Klot
* Gabilin
* Klot
* Menodin
* Modr Toluidinova
* Modr Zasadita 17
* Schultz 1041
* Tolazul
* Tolonium chloride
* Toluidinblau
* Toluidine Blue
* Toluidine Blue O
* Toluidine Blue OO
* Toluidine Blue (phenothiazine dye)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 43 mg/kg/6D
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - other changes
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,597,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 204,288,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28930 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 27560 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 17,902,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 13440 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,255,1992
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 500 ppm
REFERENCE :
14ZYA8 "Induction of Mutations and the Mutation Process, Proceedings of a
Symposium, Prague, Czechoslovakia, 1963," Veleminsky, J., and T. Gichnar,
eds., Prague, Academia, 1965 Volume(issue)/page/year: -,115,1965
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1164
No. of Facilities: 224 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1226 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1164
No. of Facilities: 196 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 7956 (estimated)
No. of Female Employees: 5824 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; S cerevisiae
gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Phenol, o-octyl-
| 949-13-3 |
10H-Phenothiazine,10-(((tetrahydro-5-((4-methoxyphenyl)methylene)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-62-0 |
10H-Phenothiazine,10-(((tetrahydro-5-(((2-methylphenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-50-6 |
10H-Phenothiazine,10-(((tetrahydro-5-(((3-methylphenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-48-2 |
10H-Phenothiazine,10-(((tetrahydro-5-((4-morpholinylamino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-53-9 |
10H-Phenothiazine,10-(((tetrahydro-5-((1-naphthalenylamino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-58-4 |
10H-Phenothiazine,10-(((tetrahydro-5-(((3-nitrophenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-55-1 |
10H-Phenothiazine,10-(((tetrahydro-5-(((4-nitrophenyl)amino)methyl)-4,6-dioxo-3-phenyl-2-thioxo-1(2H)-pyrimidinyl)amino)acetyl)-
| 141177-54-0 |
10H-Phenothiazine,10-(2-(2,2,6,6-tetramethyl-1-piperidinyl)ethyl)-,monohydrochloride
| 141177-54-0 |
10H-Phenothiazine,10-((2,4,6-tribromophenoxy)acetyl)-
| 136776-26-6 |
Phenothiazine, 2-(trifluoromethyl)-
| 92-30-8 |
Phenol, 3-(1-oxa-4-azaspiro(4.5)dec-2-yl)-
| 25283-29-8 |
Phenothiazine, 4-(trifluoromethyl)-
| 343-21-5 |
10H-Phenothiazine,10-(((1-(2,3,4-trihydroxyphenyl)ethylidene)hydrazino)acetyl)-
| 68026-86-8 |
10H-Phenothiazine,10-((2,4,6-trinitrophenoxy)acetyl)-
| 136776-24-4 |
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-,chloride
| 531-53-3 |
Phenothiazin-5-ium,3-amino-7-(dimethylamino)-2-methyl-, chloride
| 92-31-9 |
Phenothiazin-5-ium, 3-amino-7-methylamino-, chloride
| 531-57-7 |
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-,chloride, trihydrate
| 7220-79-3 |
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-4-nitro-,chloride
| 2679-01-8 |
Phenoxarsine, 10-chloro-
| 2865-70-5 |
Phenoxarsine,10-((N,N-dimethylamino)thiocarbonylthio)-
| 2865-70-5 |
Phenol, 2-(1,3,4-oxadiazol-2-yl)-
| 1008-65-7 |
Phenoxarsine, 10,10'-oxydi-
| 58-36-6 |
Phenoxarsine, 10-((phenoxyacetyl)thio)-
| 7393-66-0 |
Phenoxathiin
| 262-20-4 |
Phenoxathiin, 2-dichloroarsino-
| 63834-20-8 |
Phenoxathiin, 10,10-dioxide
| 950-47-0 |
Phenoxathiinium, 2-chloro-10-methyl-,tetrafluoroborate(1-)
| 15615-40-4 |
Phenoxathiinium, 10-methyl-, tetrafluoroborate(1-)
| 15615-39-1 |
Phenoxathiin, 10-oxide
| 948-44-7 |
10H-Phenoxazine-1-carboxamide,N-(2-(dimethylamino)ethyl)-
| 112022-13-6 |
Phenoxazine-10-carbothioic acid,S-(2-(diethylamino)ethyl) ester, hydrochloride
| 1945-75-1 |
Phenol, 2,2'-(1,3,4-oxadiazol-2,5-ylene)bis(4-amino-
| 95452-62-3 |
Phenoxazine-10-carbothioic acid,S-(2-(dimethylamino)ethyl) ester, hydrochloride
| 1936-49-8 |
Phenoxazine-10-carboxylic acid, 2-(diethylamino)ethylester, hydrochloride
| 2278-23-1 |
Phenoxazine, 2-chloro-10-(3-(dimethylamino)propyl)-,hydrochloride
| 98175-98-5 |
3H-Phenoxazine-4,6-dicarboxylic acid, 2-amino-3-oxo-,dimethyl ester
| 35748-35-7 |
Phenoxazine, 10-(3-(dimethylamino)propyl)-,hydrochloride
| 36982-02-2 |
Phenoxazine, 10-(3-(dimethylamino)propyl)-, phosphate
| 2278-24-2 |
Phenoxazine, 10-(3-(4-methoxypiperidino)propyl)-
| 97018-26-3 |
Phenoxazine, 10-(3-piperidinopropyl)-
| 95554-67-9 |
Phenoxazin-5-ium,7-amino-3-(dimethylamino)-2-methyl-, chloride
| 63834-21-9 |
Phenoxazin-5-ium,3-(diethylamino)-7-(dimethylamino)-2-methyl-,chloride
| 1787-57-1 |
Phenol, o,o'-(1,3,4-oxadiazol-2,5-ylene)di-
| 2491-96-5 |
Phenoxazin-5-ium,1-carboxy-7-(dimethylamino)-3,4-dihydroxy-, chloride
| 1562-85-2 |
3H-Phenoxazin-3-one, 2-amino-
| 1916-59-2 |
3H-Phenoxazin-3-one, 7-hydroxy-
| 635-78-9 |
3H-Phenoxazin-3-one, 7-hydroxy-, 10-oxide
| 550-82-3 |
Phenoxysulfonyl fluoride
| 330-00-7 |
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