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MSDS  
:
 Phosphonic acid, bis(2-ethylhexyl) ester
CAS  
:
 3658-48-8
SYNONYMS  
:
 * Bis(2-ethylhexyl) hydrogen phosphite
* Bis(2-ethylhexyl) phosphite
* Bis(2-ethylhexyl) phosphonate
* Bis(2-ethylhexyl) phosphonic acid
* Chelex H 8
* Di-2-ethylhexyl hydrogen phosphite
* Di-2-ethylhexyl phosphite
* Diisooctyl phosphite

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ6840000
CHEMICAL NAME           : Phosphonic acid, bis(2-ethylhexyl) ester
CAS REGISTRY NUMBER     : 3658-48-8
BEILSTEIN REFERENCE NO. : 1711893
REFERENCE               : 4-01-00-01785 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C16-H35-O3-P
MOLECULAR WEIGHT        : 306.48
WISWESSER LINE NOTATION : 4Y2&1OPHO&O1Y4&2
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Bis(2-ethylhexyl) hydrogen phosphite
   * Bis(2-ethylhexyl) phosphite
   * Bis(2-ethylhexyl) phosphonate
   * Bis(2-ethylhexyl) phosphonic acid
   * Chelex H 8
   * Di-2-ethylhexyl hydrogen phosphite
   * Di-2-ethylhexyl phosphite
   * Diisooctyl phosphite
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg
REACTION SEVERITY       : Mild
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 18,464,1958
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ALBRW* Albright & Wilson Inc.  (P.O. Box 26229, Richmond, VA 23260-6229)
   Volume(issue)/page/year: #OPB-3,1984
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >20 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ALBRW* Albright & Wilson Inc.  (P.O. Box 26229, Richmond, VA 23260-6229)
   Volume(issue)/page/year: #OPB-3,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 18,464,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 18,464,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ALBRW* Albright & Wilson Inc.  (P.O. Box 26229, Richmond, VA 23260-6229)
   Volume(issue)/page/year: #OPB-3,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 18,464,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 18,464,1958

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1156
       No. of Facilities: 1888 (estimated)
       No. of Industries: 16
       No. of Occupations: 17
       No. of Employees: 13678 (estimated)
       No. of Female Employees: 80 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphonic acid, benzyl-, dibutyl ester 3762-27-4
Phosphonic acid, benzyl-, diethyl ester 1080-32-6
Phosphonic acid, benzyl-, ethyl p-nitrophenyl ester 3015-70-1
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinothioyl)ethyl)-, dibutylester 2275-49-2
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinothioyl)ethyl)-, diethylester 2611-84-9
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinyl)ethyl)-, dibutylester 2611-85-0
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinyl)ethyl)-, diethylester 2393-09-1
Phosphonic acid,((3-(bis(2-chloroethyl)amino)-4-methylphenyl)hydroxymethylene)bis- 106871-13-0
Phosphonic acid,(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-hydroxybutylidene)bis- 104233-81-0
Phosphonic acid, bis(2-ethylhexyl) ester 3658-48-8
Phosphine oxide,diphenyl((alpha-phenyl-alpha-((2-morpholino)ethyl))benzyl)-, hydrochloride 51713-29-2
Phosphonic acid, ((bis(2-hydroxyethyl)amino)methyl)-,diethyl ester 2781-11-5
Phosphonic acid, (2-bromo-3-chloropropyl)-,bis(2-bromo-1-(chloromethyl)ethyl) ester 95906-07-3
Phosphonic acid, (2-bromoethyl)-, dibutyl ester 74038-35-0
Phosphonic acid, (bromo(hydroxyimino)methyl)-,bis(1-methylethyl) ester 127933-58-8
Phosphonic acid, (m-bromophenyl)- 6959-02-0
Phosphonic acid, (o-bromophenyl)- 7506-82-3
Phosphonic acid, (p-bromophenyl)- 16839-13-7
Phosphonic acid, 1-(butylamino)cyclohexyl-, dibutylester 51249-05-9
Phosphonic acid, (m-butylaminophenyl)- 102880-19-3
Phosphonic acid, (alpha-butylbenzyl)-, diethyl ester 33973-56-7
Phosphine oxide,diphenyl((alpha-phenyl-alpha-((2-piperidino)ethyl))benzyl)-, hydrochloride 51713-28-1
Phosphonic acid, butyl-, butyl p-nitrophenyl ester 71002-68-1
Phosphonic acid, butyl-, dibutyl ester 78-46-6
Phosphonic acid, butyl-, ethyl p-nitrophenyl ester 3015-74-5
Phosphonic acid, butyl-, monoethyl ester, anhydridewith diethyl phosphate 63886-51-1
Phosphonic acid, (p-chlorobenzyl)-, dibutyl ester 74038-36-1
Phosphonic acid, 4-chlorobutyl-, ethyl p-nitrophenylester 3015-81-4
Phosphonic acid, (2-chloroethyl)- 16672-87-0
Phosphonic acid, (2-chloroethyl)-, diethyl ester 10419-79-1
Phosphonic acid, (2-chloroethyl)-, monoethyl ester 23510-39-6
Phosphonic acid,(1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester 92118-27-9
Phosphine oxide,diphenyl((alpha-phenyl-alpha-((2-pyrrolidinyl)ethyl))benzyl)-, hydrochloride 51749-95-2
Phosphonic acid, (2-chloroethyl)-, compd. with1,3,5,7-tetraazatricyclo(3.3.1.1(3,7))decane (1:1) 134576-33-3
Phosphonic acid, 6-chlorohexyl-, ethyl p-nitrophenylester 3015-82-5
Phosphonic acid, (chloro(hydroxyimino)methyl)-,bis(1-methylethyl) ester 127933-57-7
Phosphonic acid, chloromethyl-, cyclicmethylene-o-phenylene ester 5853-71-4
Phosphonic acid, (2-chloro-1-methylethyl)-,bis(2-chloro-1-methylethyl) ester 7316-55-4
Phosphonic acid, (2-chloro-4-nitrophenyl)- 114792-24-4
Phosphonic acid, (2-chloro-5-nitro-4-pyrimidinyl)-,dimethyl ester 72900-86-8
Phosphonic acid, p-(m-chlorophenoxy)phenyl-,bis(alpha,alpha,alpha-trifluoro-m-tolyl) ester 74038-37-2
Phosphonic acid, (m-chlorophenyl)- 5431-34-5
Phosphonic acid, (o-chlorophenyl)- 5431-19-6
Phosphine oxide, bis(1-aziridinyl)vinyl- 2275-41-4
Phosphine oxide,diphenyl((alpha-(2-piperidino)ethyl)benzyl)- 51713-16-7
Phosphonic acid, (p-chlorophenyl)- 5431-35-6
Phosphonic acid, (p-chlorophenyl)-, diethyl ester 2373-43-5
Phosphonic acid,(3-(4-chlorophenyl)-4,5-dihydro-5-isoxazolyl)- 125674-56-8
Phosphonic acid,((3-(4-chlorophenyl)-4,5-dihydro-5-isoxazolyl)methyl)- 125674-57-9
Phosphonic acid,(4-((p-chlorophenyl)hydroxyphenylmethyl)piperidino)-,diethyl ester 125674-57-9

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