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MSDS  : Phosphonic difluoride, methyl-
CAS  : 676-99-3
SYNONYMS  : * Difluoro * Difluoromethylphosphine oxide * Methyl difluorophosphite * Methylphosphonic difluoride * Methylphosphonyldifluoride * Phosphonodifluoridic acid, methyl-
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TA1840700
CHEMICAL NAME : Phosphonic difluoride, methyl-
CAS REGISTRY NUMBER : 676-99-3
BEILSTEIN REFERENCE NO. : 1739375
REFERENCE : 4-04-00-03508 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C-H3-F2-O-P
MOLECULAR WEIGHT : 100.01
WISWESSER LINE NOTATION : OPFF1
SYNONYMS/TRADE NAMES :
* Difluoro
* Difluoromethylphosphine oxide
* Methyl difluorophosphite
* Methylphosphonic difluoride
* Methylphosphonyldifluoride
* Phosphonodifluoridic acid, methyl-

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1842 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Skin and Appendages - dermatitis, other (after systemic exposure)
Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1842 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 114 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1842 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - cyanosis
Nutritional and Gross Metabolic - dehydration
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 25800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 2608 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - aggression
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 26900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974

TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,22,1984

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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Phosphonic dichloride, methyl- 676-97-1
Phosphonic dichloride, (2-(3-phenylureido)vinyl)- 51824-61-4
Phosphonic dichloride, piperidino- 1498-56-2
Phosphonic dichloride, (2-(3-(p-tolyl)ureido)vinyl)- 54948-15-1
Phosphonic dichloride,(2-(3-(2,4-xylyl)ureido)vinyl)- 54948-17-3
Phosphonic difluoride, methyl- 676-99-3
Phosphonium, acetonyltriphenyl-, chloride 1235-21-8
Phosphonium, acetonyltriphenyl-, iodide 65602-18-8
Phosphine oxide,tris(alpha,alpha,alpha-trifluoro-m-tolyl)- 74038-21-4
Phosphonium, allyltributyl-, bromide 55894-18-3
Phosphonium, allyltributyl-, chloride 1530-48-9
Phosphonium, allyltriphenyl-, bromide 1560-54-9
Phosphonium, allyltriphenyl-, iodide 21433-41-0
Phosphonium, benzyltributyl-, chloride 1224-56-2
Phosphonium, benzyltriphenyl-, iodide 1243-97-6
Phosphonium, bis(p-butylamino)benzylphenyl-, iodide 73790-35-9
Phosphonium, bis(t-butylamino)methylphenyl-, iodide 15916-97-9
Phosphonium, bis(hydroxymethyl)methylphenyl-, iodide 85684-36-2
Phosphonium, (o-bromomethylbenzyl)triphenyl-, bromide 67219-44-7
Phosphine, phenyl- 638-21-1
Phosphonium, (p-bromomethylbenzyl)triphenyl-, bromide 14366-74-6
Phosphonium, butyltriphenyl-, bromide 1779-51-7
Phosphonium, butyltriphenyl-, iodide 22949-84-4
Phosphonium, butyltris(dibutylamino)-, bromide 73790-36-0
Phosphonium, (carbamoylmethyl)triphenyl-, chloride 25361-54-0
Phosphonium,(carbonylbis(iminomethylene))bis(tris(hydroxymethyl)- 87957-27-5
Phosphonium, (carboxymethyl)triethyl-, bromide, ethylester 32348-62-2
Phosphonium, carboxymethyltriphenyl-, chloride 7343-26-2
Phosphonium,(p-chloromethylbenzyl)tris(dimethylamino)-, chloride 73790-37-1
Phosphonium, chloromethyltriphenyl-, chloride 5293-84-5
Phosphine, phenyl (di-1-piperidyl)- 14287-62-8
Phosphonium, ((5-chloro-2-thienyl)methyl)tributyl-,chloride 33060-84-3
Phosphonium, (cyanomethyl)triphenyl-, chloride 4336-70-3
Phosphonium, decamethylenebis(tris(dimethylamino)-,diiodide 73805-85-3
Phosphonium, decyltriphenyl-,bromochlorotriphenylstannate 15652-38-7
Phosphonium, (2,4-dichlorobenzyl)triphenyl-, chloride 2492-23-1
Phosphonium, (3,4-dichlorobenzyl)triphenyl-, chloride 3687-70-5
Phosphonium, (2,4-dichlorobenzyl)triphenyl-, iodide 73790-38-2
Phosphonium,(2,4-dichlorobenzyl)tris(p-dimethylaminophenyl)-,chloride 73790-39-3
Phosphonium,(2,4-dichlorobenzyl)tris(p-methylthiophenyl)-,chloride 73790-40-6
Phosphonium, (2,4-dichlorobenzyl)tris(p-tolyl)-,iodide 73790-41-7
Phosphine selenide, trimethyl- 20819-54-9
Phosphonium, (2,4-dichlorobenzyl)tri(p-tolyl)-,chloride 73790-42-8
Phosphonium, (dichloromethyl)tripiperidino-,perchlorate 73790-43-9
Phosphonium,(p,alpha-dichloro-alpha-(p-nitrobenzyl)phenacyl)triphenyl-, chloride 33013-60-4
Phosphonium, (2,4-dimethylbenzyl)tributyl-, chloride 73790-44-0
Phosphonium,(2,5-dimethyl-p-phenylene)bis(triphenyl-, dibromide 102305-51-1
Phosphonium, (2-(ethenyloxy)-2-oxoethyl)triphenyl-,chloride, homopolymer 55586-12-4

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