*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TA1840700
CHEMICAL NAME : Phosphonic difluoride, methyl-
CAS REGISTRY NUMBER : 676-99-3
BEILSTEIN REFERENCE NO. : 1739375
REFERENCE : 4-04-00-03508 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C-H3-F2-O-P
MOLECULAR WEIGHT : 100.01
WISWESSER LINE NOTATION : OPFF1
SYNONYMS/TRADE NAMES :
* Difluoro
* Difluoromethylphosphine oxide
* Methyl difluorophosphite
* Methylphosphonic difluoride
* Methylphosphonyldifluoride
* Phosphonodifluoridic acid, methyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1842 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Skin and Appendages - dermatitis, other (after systemic exposure)
Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1842 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 114 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1842 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - cyanosis
Nutritional and Gross Metabolic - dehydration
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 25800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 2608 mg/m3/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - aggression
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,131,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 26900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,22,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Phosphonic dichloride,(2-(3-(p-methoxyphenyl)ureido)vinyl)-
| 54948-16-2 |
Phosphonic dichloride,(2-(3-(5-methoxy-2-pyrimidinyl)ureido)vinyl)-
| 54948-18-4 |
Phosphonic dichloride, methyl-
| 676-97-1 |
Phosphonic dichloride, (2-(3-phenylureido)vinyl)-
| 51824-61-4 |
Phosphonic dichloride, piperidino-
| 1498-56-2 |
Phosphonic dichloride, (2-(3-(p-tolyl)ureido)vinyl)-
| 54948-15-1 |
Phosphonic dichloride,(2-(3-(2,4-xylyl)ureido)vinyl)-
| 54948-17-3 |
Phosphonic difluoride, methyl-
| 676-99-3 |
Phosphonium, acetonyltriphenyl-, chloride
| 1235-21-8 |
Phosphonium, acetonyltriphenyl-, iodide
| 65602-18-8 |
Phosphine oxide,tris(alpha,alpha,alpha-trifluoro-m-tolyl)-
| 74038-21-4 |
Phosphonium, allyltributyl-, bromide
| 55894-18-3 |
Phosphonium, allyltributyl-, chloride
| 1530-48-9 |
Phosphonium, allyltriphenyl-, bromide
| 1560-54-9 |
Phosphonium, allyltriphenyl-, iodide
| 21433-41-0 |
Phosphonium, benzyltributyl-, chloride
| 1224-56-2 |
Phosphonium, benzyltriphenyl-, iodide
| 1243-97-6 |
Phosphonium, bis(p-butylamino)benzylphenyl-, iodide
| 73790-35-9 |
Phosphonium, bis(t-butylamino)methylphenyl-, iodide
| 15916-97-9 |
Phosphonium, bis(hydroxymethyl)methylphenyl-, iodide
| 85684-36-2 |
Phosphonium, (o-bromomethylbenzyl)triphenyl-, bromide
| 67219-44-7 |
Phosphine, phenyl-
| 638-21-1 |
Phosphonium, (p-bromomethylbenzyl)triphenyl-, bromide
| 14366-74-6 |
Phosphonium, butyltriphenyl-, bromide
| 1779-51-7 |
Phosphonium, butyltriphenyl-, iodide
| 22949-84-4 |
Phosphonium, butyltris(dibutylamino)-, bromide
| 73790-36-0 |
Phosphonium, (carbamoylmethyl)triphenyl-, chloride
| 25361-54-0 |
Phosphonium,(carbonylbis(iminomethylene))bis(tris(hydroxymethyl)-
| 87957-27-5 |
Phosphonium, (carboxymethyl)triethyl-, bromide, ethylester
| 32348-62-2 |
Phosphonium, carboxymethyltriphenyl-, chloride
| 7343-26-2 |
Phosphonium,(p-chloromethylbenzyl)tris(dimethylamino)-, chloride
| 73790-37-1 |
Phosphonium, chloromethyltriphenyl-, chloride
| 5293-84-5 |
Phosphine, phenyl (di-1-piperidyl)-
| 14287-62-8 |
Phosphonium, ((5-chloro-2-thienyl)methyl)tributyl-,chloride
| 33060-84-3 |
Phosphonium, (cyanomethyl)triphenyl-, chloride
| 4336-70-3 |
Phosphonium, decamethylenebis(tris(dimethylamino)-,diiodide
| 73805-85-3 |
Phosphonium, decyltriphenyl-,bromochlorotriphenylstannate
| 15652-38-7 |
Phosphonium, (2,4-dichlorobenzyl)triphenyl-, chloride
| 2492-23-1 |
Phosphonium, (3,4-dichlorobenzyl)triphenyl-, chloride
| 3687-70-5 |
Phosphonium, (2,4-dichlorobenzyl)triphenyl-, iodide
| 73790-38-2 |
Phosphonium,(2,4-dichlorobenzyl)tris(p-dimethylaminophenyl)-,chloride
| 73790-39-3 |
Phosphonium,(2,4-dichlorobenzyl)tris(p-methylthiophenyl)-,chloride
| 73790-40-6 |
Phosphonium, (2,4-dichlorobenzyl)tris(p-tolyl)-,iodide
| 73790-41-7 |
Phosphine selenide, trimethyl-
| 20819-54-9 |
Phosphonium, (2,4-dichlorobenzyl)tri(p-tolyl)-,chloride
| 73790-42-8 |
Phosphonium, (dichloromethyl)tripiperidino-,perchlorate
| 73790-43-9 |
Phosphonium,(p,alpha-dichloro-alpha-(p-nitrobenzyl)phenacyl)triphenyl-, chloride
| 33013-60-4 |
Phosphonium, (2,4-dimethylbenzyl)tributyl-, chloride
| 73790-44-0 |
Phosphonium,(2,5-dimethyl-p-phenylene)bis(triphenyl-, dibromide
| 102305-51-1 |
Phosphonium, (2-(ethenyloxy)-2-oxoethyl)triphenyl-,chloride, homopolymer
| 55586-12-4 |
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