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MSDS  : Phosphonic acid, (1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethy l)-, diethyl ester
CAS  : 92118-27-9
SYNONYMS  : * Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate * Fotemustina * Fotemustine * S 10036 * Servier-10036
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SZ7115500
CHEMICAL NAME : Phosphonic acid,
(1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethy
l)-, diethyl ester
CAS REGISTRY NUMBER : 92118-27-9
LAST UPDATED : 199410
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C9-H19-Cl-N3-O5-P
MOLECULAR WEIGHT : 315.73
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate
* Fotemustina
* Fotemustine
* S 10036
* Servier-10036

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,6782,1987

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5100 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,101,1993

*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphonic acid, benzyl-, dibutyl ester 3762-27-4
Phosphonic acid, benzyl-, diethyl ester 1080-32-6
Phosphonic acid, benzyl-, ethyl p-nitrophenyl ester 3015-70-1
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinothioyl)ethyl)-, dibutylester 2275-49-2
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinothioyl)ethyl)-, diethylester 2611-84-9
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinyl)ethyl)-, dibutylester 2611-85-0
Phosphonic acid,(2-(bis(1-aziridinyl)phosphinyl)ethyl)-, diethylester 2393-09-1
Phosphonic acid,((3-(bis(2-chloroethyl)amino)-4-methylphenyl)hydroxymethylene)bis- 106871-13-0
Phosphonic acid,(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-hydroxybutylidene)bis- 104233-81-0
Phosphonic acid, bis(2-ethylhexyl) ester 3658-48-8
Phosphine oxide,diphenyl((alpha-phenyl-alpha-((2-morpholino)ethyl))benzyl)-, hydrochloride 51713-29-2
Phosphonic acid, ((bis(2-hydroxyethyl)amino)methyl)-,diethyl ester 2781-11-5
Phosphonic acid, (2-bromo-3-chloropropyl)-,bis(2-bromo-1-(chloromethyl)ethyl) ester 95906-07-3
Phosphonic acid, (2-bromoethyl)-, dibutyl ester 74038-35-0
Phosphonic acid, (bromo(hydroxyimino)methyl)-,bis(1-methylethyl) ester 127933-58-8
Phosphonic acid, (m-bromophenyl)- 6959-02-0
Phosphonic acid, (o-bromophenyl)- 7506-82-3
Phosphonic acid, (p-bromophenyl)- 16839-13-7
Phosphonic acid, 1-(butylamino)cyclohexyl-, dibutylester 51249-05-9
Phosphonic acid, (m-butylaminophenyl)- 102880-19-3
Phosphonic acid, (alpha-butylbenzyl)-, diethyl ester 33973-56-7
Phosphine oxide,diphenyl((alpha-phenyl-alpha-((2-piperidino)ethyl))benzyl)-, hydrochloride 51713-28-1
Phosphonic acid, butyl-, butyl p-nitrophenyl ester 71002-68-1
Phosphonic acid, butyl-, dibutyl ester 78-46-6
Phosphonic acid, butyl-, ethyl p-nitrophenyl ester 3015-74-5
Phosphonic acid, butyl-, monoethyl ester, anhydridewith diethyl phosphate 63886-51-1
Phosphonic acid, (p-chlorobenzyl)-, dibutyl ester 74038-36-1
Phosphonic acid, 4-chlorobutyl-, ethyl p-nitrophenylester 3015-81-4
Phosphonic acid, (2-chloroethyl)- 16672-87-0
Phosphonic acid, (2-chloroethyl)-, diethyl ester 10419-79-1
Phosphonic acid, (2-chloroethyl)-, monoethyl ester 23510-39-6
Phosphonic acid,(1-((((2-chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-, diethyl ester 92118-27-9
Phosphine oxide,diphenyl((alpha-phenyl-alpha-((2-pyrrolidinyl)ethyl))benzyl)-, hydrochloride 51749-95-2
Phosphonic acid, (2-chloroethyl)-, compd. with1,3,5,7-tetraazatricyclo(3.3.1.1(3,7))decane (1:1) 134576-33-3
Phosphonic acid, 6-chlorohexyl-, ethyl p-nitrophenylester 3015-82-5
Phosphonic acid, (chloro(hydroxyimino)methyl)-,bis(1-methylethyl) ester 127933-57-7
Phosphonic acid, chloromethyl-, cyclicmethylene-o-phenylene ester 5853-71-4
Phosphonic acid, (2-chloro-1-methylethyl)-,bis(2-chloro-1-methylethyl) ester 7316-55-4
Phosphonic acid, (2-chloro-4-nitrophenyl)- 114792-24-4
Phosphonic acid, (2-chloro-5-nitro-4-pyrimidinyl)-,dimethyl ester 72900-86-8
Phosphonic acid, p-(m-chlorophenoxy)phenyl-,bis(alpha,alpha,alpha-trifluoro-m-tolyl) ester 74038-37-2
Phosphonic acid, (m-chlorophenyl)- 5431-34-5
Phosphonic acid, (o-chlorophenyl)- 5431-19-6
Phosphine oxide, bis(1-aziridinyl)vinyl- 2275-41-4
Phosphine oxide,diphenyl((alpha-(2-piperidino)ethyl)benzyl)- 51713-16-7
Phosphonic acid, (p-chlorophenyl)- 5431-35-6
Phosphonic acid, (p-chlorophenyl)-, diethyl ester 2373-43-5
Phosphonic acid,(3-(4-chlorophenyl)-4,5-dihydro-5-isoxazolyl)- 125674-56-8
Phosphonic acid,((3-(4-chlorophenyl)-4,5-dihydro-5-isoxazolyl)methyl)- 125674-57-9
Phosphonic acid,(4-((p-chlorophenyl)hydroxyphenylmethyl)piperidino)-,diethyl ester 125674-57-9

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